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公开(公告)号:US20060241149A1
公开(公告)日:2006-10-26
申请号:US10533832
申请日:2003-11-06
申请人: Jerry Adams , Deborah Bryan , Jiri Kasparec , Francis King , Andrew Takle , David Wilson , Steven Goodman
发明人: Jerry Adams , Deborah Bryan , Jiri Kasparec , Francis King , Andrew Takle , David Wilson , Steven Goodman
IPC分类号: A61K31/4439 , C07D403/02
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D409/14
摘要: Pyridinyl-benzoheterocycyl kinase inhibitor compounds are disclosed. Also disclosed are methods of making such compounds as well as methods of using the same in the treatment of diseases.
摘要翻译: 公开了吡啶基 - 苯并异环激酶抑制剂化合物。 还公开了制备这些化合物的方法以及使用该化合物治疗疾病的方法。
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公开(公告)号:US20060166988A1
公开(公告)日:2006-07-27
申请号:US11388058
申请日:2006-03-23
申请人: Jerry Adams , Deborah Bryan
发明人: Jerry Adams , Deborah Bryan
IPC分类号: A61K31/5377 , A61K31/4439 , C07D413/14 , C07D409/14
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
摘要: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
摘要翻译: 本发明涉及用于治疗哺乳动物疾病的新颖的式(I)化合物,其中发生不适当,过量或不期望的血管发生和/或已经发生过度的Tie2受体活性。
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公开(公告)号:US20050043352A1
公开(公告)日:2005-02-24
申请号:US10474084
申请日:2002-04-04
申请人: Deborah Bryan , Joelle Burgess , James Callahan
发明人: Deborah Bryan , Joelle Burgess , James Callahan
IPC分类号: A61K31/47 , A61K31/4709 , A61K31/5377 , A61P7/00 , A61P7/06 , A61P13/12 , A61P15/16 , A61P19/00 , A61P25/28 , A61P31/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P39/00 , A61P43/00 , C07D215/54 , C07D401/12
CPC分类号: C07D401/12 , A61K31/47 , A61K31/4709 , C07D215/54
摘要: This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such kinase is a factor.
摘要翻译: 本发明涉及hYAK1和hYAK3激酶的新型喹啉抑制剂及其药学上可接受的盐,水合物或溶剂化物,其药物组合物和治疗其中过量的这种激酶是因子的疾病的方法。
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公开(公告)号:US20050004142A1
公开(公告)日:2005-01-06
申请号:US10489052
申请日:2002-09-10
申请人: Jerry Adams , Deborah Bryan , Yanhong Feng , Shinichiro Matsunaga , Yutaka Maeda , Yasushi Miyazaki , Masato Nakano , Jean-Philippe Rocher , Hideyuki Sato , Marcus Semones , Domingos Silva , Jun Tang
发明人: Jerry Adams , Deborah Bryan , Yanhong Feng , Shinichiro Matsunaga , Yutaka Maeda , Yasushi Miyazaki , Masato Nakano , Jean-Philippe Rocher , Hideyuki Sato , Marcus Semones , Domingos Silva , Jun Tang
IPC分类号: C07D491/048 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/16 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D491/04 , C07D495/04 , C07D519/00 , C07D491/02
CPC分类号: C07D491/04 , C07D495/04
摘要: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的呋喃和噻吩并嘧啶衍生物。 所述的发明还包括制备这些呋喃并噻吩并嘧啶衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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