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1.发明授权Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same 有权来自功能化的β-内酰胺单体的聚-β-肽和含有它们的抗菌组合物公开(公告)号：US08519095B2
公开(公告)日：2013-08-27
申请号：US12759998
申请日：2010-04-14
申请人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
发明人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备β-多肽的方法。 该方法包括在碱基引发剂和不是含金属分子的共引发剂存在下聚合含β-内酰胺的单体以产生产物β-多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法，反应在溶剂 如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃。
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2.发明授权Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same 有权来自功能化的β-内酰胺单体的聚合物和包含其的抗菌组合物公开(公告)号：US09120892B2
公开(公告)日：2015-09-01
申请号：US13075218
申请日：2011-03-30
发明人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
IPC分类号： C07K1/02 , C12P21/00 , C08G69/22 , C07D205/08 , C07D205/12
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备＆bgr-多肽的方法。 该方法包括在碱性引发剂和不是含金属的分子的共引发剂存在下聚合并含有内含物的单体，以产生产物和多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法，反应在溶剂 如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃。
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3.发明申请POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME 有权来自功能化的BETA-LACTAM单体和含有其的抗菌组合物的聚-β-肽公开(公告)号：US20110196127A1
公开(公告)日：2011-08-11
申请号：US13075218
申请日：2011-03-30
申请人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
发明人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
IPC分类号： C07K2/00
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备＆bgr-多肽的方法。 该方法包括在碱性引发剂和不是含金属的分子的共引发剂存在下聚合并含有内含物的单体，以产生产物和多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法，反应在溶剂 如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃。
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4.发明授权Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same 有权来自功能化的β-内酰胺单体的聚合物和包含其的抗菌组合物公开(公告)号：US07951912B2
公开(公告)日：2011-05-31
申请号：US11510017
申请日：2006-08-25
申请人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
发明人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备＆bgr-多肽的方法。 该方法包括在碱性引发剂和不是含金属的分子的共引发剂存在下聚合并含有内含物的单体，以产生产物和多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法，反应在溶剂 如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃。
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5.发明申请POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME 有权来自功能化的BETA-LACTAM单体和含有其的抗菌组合物的聚-β-肽公开(公告)号：US20100222250A1
公开(公告)日：2010-09-02
申请号：US12759998
申请日：2010-04-14
申请人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
发明人： Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备＆bgr-多肽的方法。 该方法包括在碱性引发剂和不是含金属的分子的共引发剂存在下聚合并含有内含物的单体，以产生产物和多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法，反应在溶剂 如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃。
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6.发明申请RUBBERY-BLOCK CONTAINING POLYMERS, FIBER SIZINGS THEREOF AND COMPOSITES THEREOF 审中-公开含橡胶块的聚合物，其纤维尺寸及其复合材料公开(公告)号：US20100215948A1
公开(公告)日：2010-08-26
申请号：US12708907
申请日：2010-02-19
IPC分类号： B32B5/02 , D02G3/36 , C08L33/10 , C08K3/38 , C08K3/22 , C08K3/34 , C08K3/36 , C08L53/00 , C08F8/32
CPC分类号： C03C25/26 , C03C25/27 , C03C25/40 , C03C25/47 , C04B20/1033 , C04B2103/0061 , C08F8/32 , C08J5/04 , C08J2321/00 , Y10T428/254 , Y10T428/2918 , Y10T428/2938 , C04B14/386 , C04B14/42 , C04B20/1062 , C04B20/1066 , C04B20/1074 , C08F297/048 , C08F297/026
摘要： The present invention relates generally to sizing compositions for fibers used in composite materials. More specifically, this invention relates to siloxane fiber sizing solutions comprising rubbery-polymers and their use in preparing composite materials. Using the sizings of the present invention not only improves the energy absorption of the composite materials made thereof, but also maintains the interfacial strength of composite materials. Particularly, the rubbery-polymers of the present invention are functionalized with chemical groups that react to the fiber surface and/or to the polymeric resin. In addition, because the rubbery-polymer is incorporated as one block of a block copolymer, it advantageously improves both, the interfacial strength and energy absorption.
摘要翻译： 本发明一般涉及用于复合材料的纤维的上胶组合物。 更具体地，本发明涉及包含橡胶聚合物的硅氧烷纤维上浆溶液及其在制备复合材料中的用途。 使用本发明的这些特征，不仅提高了由其制成的复合材料的能量吸收，而且还保持复合材料的界面强度。 特别地，本发明的橡胶聚合物用与纤维表面和/或聚合树脂反应的化学基团官能化。 此外，由于橡胶状聚合物作为嵌段共聚物的一个嵌段结合，所以有利地改善界面强度和能量吸收。
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7.发明申请Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same 有权来自功能化的β-内酰胺单体的聚-β-肽和含有它们的抗菌组合物公开(公告)号：US20070087404A1
公开(公告)日：2007-04-19
申请号：US11510017
申请日：2006-08-25
申请人： Shannon Stahl , Samuel Gellman , Sarah Lee , Mehmet Ilker , Bernard Weisblum , Denis Kissounko
发明人： Shannon Stahl , Samuel Gellman , Sarah Lee , Mehmet Ilker , Bernard Weisblum , Denis Kissounko
CPC分类号： C08G69/22 , A61K38/16 , C07D205/08 , C07D205/12 , C07K1/02
摘要： Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
摘要翻译： 公开了制备β-多肽的方法。 该方法包括在碱基引发剂和不是含金属分子的共引发剂存在下聚合含β-内酰胺的单体以产生产物β-多肽。 具体公开的是其中碱引发剂为叔丁醇钾，双（三甲基甲硅烷基）氨基锂（LiN（TMS）2），双（三甲基甲硅烷基）酰胺钾和乙醇钠的方法， 反应在溶剂如氯仿，二氯甲烷，二甲基亚砜或四氢呋喃中进行。
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