利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.023 秒)

    Diagnosis of coeliac disease using a gliadin epitope
    3.
    发明授权
    Diagnosis of coeliac disease using a gliadin epitope 有权
    使用麦醇溶蛋白表位诊断乳糜泻

    公开(公告)号：US07144569B1

    公开(公告)日：2006-12-05

    申请号：US10089700

    申请日：2000-10-02

    申请人： Robert Paul Anderson ,  Adrian Vivian Sinton Hill ,  Derek Parry Jewell

    发明人： Robert Paul Anderson ,  Adrian Vivian Sinton Hill ,  Derek Parry Jewell

    IPC分类号： A61K39/35 ,  C07K7/04 ,  G01N33/53

    CPC分类号： C07K14/415 ,  A61K49/0006 ,  C12N15/8257 ,  C12N15/8258 ,  G01N33/505 ,  G01N33/564 ,  G01N33/6854 ,  G01N33/6863 ,  G01N33/6878 ,  G01N2333/9108 ,  Y10S435/975

    摘要： A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, (ii) an epitope comprising sequence comprising: SEQ ID NO: 1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, which epitope is an isolated oligopeptide derived from a gliadin protein, (ii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognises the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided.

    摘要翻译： 一种在个体中诊断乳糜泻或乳糜泻易感性的方法，包括：（a）使来自宿主的样品与选自以下的试剂接触：（i）包含SEQ ID NO：1或2的序列的表位， 或由SEQ ID NO：3表示的麦醇溶蛋白的天然存在的同系物的等同序列，（ii）包含SEQ ID NO：1的序列的表位，或由SEQ ID NO：3表示的麦醇溶蛋白的天然存在的同源物的等同序列 SEQ ID NO：3，该表位是衍生自麦醇溶蛋白的分离的寡肽，（ii）能够被识别为（i）或（ii）的T细胞受体识别的（i）或（ii） 在肽类似物的情况下长度不超过50个氨基酸，或（iv）包含（i），（ii）或（iii）中定义的两种或更多种试剂的产品，和（b）确定 体外T细胞是否识别代谢物; T细胞的识别表明个体具有或易患乳糜泻。 还提供了包含不引起乳糜泻的表位和麦醇溶蛋白的治疗组合物。

    DIAGNOSIS AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT
    4.
    发明申请
    DIAGNOSIS AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT 审中-公开
    诊断和治疗方案，以及转基因植物

    公开(公告)号：US20130318648A1

    公开(公告)日：2013-11-28

    申请号：US13672183

    申请日：2012-11-08

    申请人： ROBERT PAUL ANDERSON ,  ADRIAN VIVIAN HILL ,  DEREK PARRY JEWELL

    发明人： ROBERT PAUL ANDERSON ,  ADRIAN VIVIAN HILL ,  DEREK PARRY JEWELL

    IPC分类号： C07K14/415 ,  A61K49/00 ,  C12N15/82 ,  G01N33/68

    CPC分类号： C07K14/415 ,  A61K49/0006 ,  C12N15/8257 ,  C12N15/8258 ,  G01N33/505 ,  G01N33/564 ,  G01N33/6854 ,  G01N33/6863 ,  G01N33/6878 ,  G01N2333/9108 ,  Y10S435/975

    摘要： A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, (ii) an epitope comprising sequence comprising: SEQ ID NO: 1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, which epitope is an isolated oligopeptide derived from a gliadin protein, (iii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognise the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided.

    摘要翻译： 一种在个体中诊断乳糜泻或乳糜泻易感性的方法，包括：（a）使来自宿主的样品与选自以下的试剂接触：（i）包含SEQ ID NO：1或2的序列的表位， 或由SEQ ID NO：3表示的麦醇溶蛋白的天然存在的同系物的等同序列，（ii）包含SEQ ID NO：1的序列的表位，或由SEQ ID NO：3表示的麦醇溶蛋白的天然存在的同源物的等同序列 SEQ ID NO：3，其表位是衍生自麦醇溶蛋白的分离的寡肽，（iii）能够被T细胞受体识别的（i）或（ii）的类似物，其识别（i）或（ii） 在肽类似物的情况下长度不超过50个氨基酸，或（iv）包含（i），（ii）或（iii）中定义的两种或更多种试剂的产品，和（b）确定 体外T细胞是否识别样品; T细胞的识别表明个体具有或易患乳糜泻。 还提供了包含不引起乳糜泻的表位和麦醇溶蛋白的治疗组合物。