利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.052 秒)

    Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors
    1.
    发明授权
    Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors 失效
    单结构域配体，包含所述配体的用于其生产的方法的受体，以及所述配体和受体的使用

    公开(公告)号：US06248516B1

    公开(公告)日：2001-06-19

    申请号：US08470031

    申请日：1995-06-06

    申请人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    发明人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    IPC分类号： C12Q168

    CPC分类号： C07K16/461 ,  A61K38/00 ,  C07K2317/24 ,  C12Q1/6876

    摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis and catalysis.

    摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断和催化中的用途。

    Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
    2.
    发明授权
    Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors 失效
    单结构域配体，包含所述配体的受体，其制备方法和所述配体和受体的用途

    公开(公告)号：US06545142B1

    公开(公告)日：2003-04-08

    申请号：US09722364

    申请日：2000-11-28

    申请人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    发明人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    IPC分类号： C07H2104

    CPC分类号： C07K16/461 ,  A61K38/00 ,  C07K2317/24 ,  C12Q1/6876

    摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis or catalysis.

    摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断或催化中的用途。

    Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
    3.
    发明授权
    Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors 失效
    单结构域配体，包含所述配体的受体，其制备方法和所述配体和受体的用途

    公开(公告)号：US07306907B2

    公开(公告)日：2007-12-11

    申请号：US10290252

    申请日：2002-11-08

    申请人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    发明人： Gregory Paul Winter ,  Elizabeth Sally Ward ,  Detlef Güssow

    IPC分类号： C12Q1/68

    CPC分类号： C07K16/461 ,  A61K38/00 ,  C07K2317/24 ,  C12Q1/6876

    摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis or catalysis.

    摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断或催化中的用途。

    Multispecific peptides
    4.
    发明授权
    Multispecific peptides 有权
    多特异性肽

    公开(公告)号：US08685890B2

    公开(公告)日：2014-04-01

    申请号：US13147289

    申请日：2010-02-04

    申请人： Gregory Paul Winter ,  Christian Heinis ,  Elise Bernard ,  David Loakes ,  John Tite ,  Marina Vaysburd ,  Daniel Paul Teufel ,  Lutz Riechmann

    发明人： Gregory Paul Winter ,  Christian Heinis ,  Elise Bernard ,  David Loakes ,  John Tite ,  Marina Vaysburd ,  Daniel Paul Teufel ,  Lutz Riechmann

    IPC分类号： C40B30/04

    CPC分类号： C12N15/1037 ,  A61K47/55 ,  A61K47/64 ,  A61K47/643 ,  C07K14/001 ,  C12N15/1044 ,  C12N15/1058 ,  C40B40/08 ,  C40B40/10 ,  C40B50/06 ,  G01N33/531

    摘要： The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.

    摘要翻译： 本发明涉及一种提供多特异性肽配体的方法，所述多特异性肽配体包含在三个或更多个氨基酸残基处共价连接到分子支架并能够结合两个或更多个单独靶标的多肽，包括以下步骤：（a）提供第一 多肽的所有组成部分，每个多肽包含两个或更多个能够与分子支架共价连接的反应性基团，以及至少一个环，其包含两个或更多个氨基酸的序列，对应于两个所述反应性基团; （b）提供如（a）所述的第二组多肽; （c）将第一组合物中的一个或多个成员的至少一个环连接到第二组合物的一个或多个成员的至少一个环，以形成至少一个包含两个环的多肽，和（d）将复合多肽（ s）至少在三个氨基酸位置分子支架。

    Prevention of aggregation of immunoglobulin light or heavy chains
    5.
    发明授权
    Prevention of aggregation of immunoglobulin light or heavy chains 有权
    防止免疫球蛋白轻链或重链聚集

    公开(公告)号：US08236931B2

    公开(公告)日：2012-08-07

    申请号：US12447908

    申请日：2007-10-26

    申请人： Rudolf M. T. De Wildt ,  Leo C James ,  Philip C Jones ,  Oliver Schon ,  Gregory Paul Winter

    发明人： Rudolf M. T. De Wildt ,  Leo C James ,  Philip C Jones ,  Oliver Schon ,  Gregory Paul Winter

    IPC分类号： C12P21/08 ,  C07K16/00 ,  C07K17/00 ,  C07K17/14 ,  A61K39/395 ,  A61K39/00

    CPC分类号： C07K16/22 ,  C07K16/241 ,  C07K16/42 ,  C07K2317/31 ,  C07K2317/567 ,  C07K2317/569

    摘要： An inhibitor of the aggregation of immunoglobulin chains is provided. The inhibitor may comprise or consist of a polypeptide which comprises or consists of (a) an amino acid sequence corresponding to the amino acid sequence of the FR1 region of an immunoglobulin light chain variable domain, or part thereof which includes amino acid residue 12, (b) an amino acid sequence corresponding to the amino acid sequence of the immunoglobulin-binding domain of bacterial superantigen Protein L, or part thereof, and/or (c) an amino acid sequence corresponding to the amino acid sequence of the immunoglobulin-binding domain of streptococcal protein G, or part thereof, or a variant, fusion or derivative thereof, or a fusion of a variant or derivative thereof which retains the ability of the parent polypeptide to inhibit aggregation of immunoglobulin chains, or domains thereof. Other versions of the inhibitor are also provided.

    摘要翻译： 提供免疫球蛋白链聚集的抑制剂。 抑制剂可以包含或由其组成，其包含（a）对应于免疫球蛋白轻链可变结构域的FR1区的氨基酸序列的氨基酸序列或其部分，其包括氨基酸残基12（ b）对应于细菌超抗原蛋白L或其部分的免疫球蛋白结合结构域的氨基酸序列的氨基酸序列和/或（c）对应于免疫球蛋白结合结构域的氨基酸序列的氨基酸序列 的链球菌蛋白G或其部分，或其变体，融合物或衍生物，或其保留母体多肽抑制免疫球蛋白链的聚集或其结构域的能力的变体或衍生物的融合物。 还提供其他版本的抑制剂。