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公开(公告)号：US20060142313A1
公开(公告)日：2006-06-29
申请号：US11354977
申请日：2006-02-16
申请人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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2.发明授权Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof 失效制备喹唑啉Rho激酶抑制剂及其中间体的方法公开(公告)号：US07645878B2
公开(公告)日：2010-01-12
申请号：US10252369
申请日：2002-09-24
申请人： Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： C07D239/94
CPC分类号： C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要： A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译： 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法，因此可用于治疗高血压和其他适应症。
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公开(公告)号：US20100137324A1
公开(公告)日：2010-06-03
申请号：US12698386
申请日：2010-02-02
申请人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： A61K31/517 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P9/10 , A61P25/00 , A61P35/00
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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4.发明申请PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF 审中-公开制备喹唑啉RHO-激酶抑制剂及其中间体的方法公开(公告)号：US20100125139A1
公开(公告)日：2010-05-20
申请号：US12619884
申请日：2009-11-17
申请人： Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： C07D403/12 , C07D239/91 , C07D405/14 , C07D239/93
CPC分类号： C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要： A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译： 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法，因此可用于治疗高血压和其他适应症。
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