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1.发明授权Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof 失效制备喹唑啉Rho激酶抑制剂及其中间体的方法公开(公告)号：US07645878B2
公开(公告)日：2010-01-12
申请号：US10252369
申请日：2002-09-24
申请人： Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： C07D239/94
CPC分类号： C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要： A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译： 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法，因此可用于治疗高血压和其他适应症。
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2.发明申请PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF 审中-公开制备喹唑啉RHO-激酶抑制剂及其中间体的方法公开(公告)号：US20100125139A1
公开(公告)日：2010-05-20
申请号：US12619884
申请日：2009-11-17
申请人： Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： C07D403/12 , C07D239/91 , C07D405/14 , C07D239/93
CPC分类号： C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要： A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译： 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法，因此可用于治疗高血压和其他适应症。
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公开(公告)号：US20060142313A1
公开(公告)日：2006-06-29
申请号：US11354977
申请日：2006-02-16
申请人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号：US20100137324A1
公开(公告)日：2010-06-03
申请号：US12698386
申请日：2010-02-02
申请人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： A61K31/517 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P9/10 , A61P25/00 , A61P35/00
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号：US20100216789A1
公开(公告)日：2010-08-26
申请号：US12688428
申请日：2010-01-15
申请人： Dhanapalan NAGARATHNAM , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan NAGARATHNAM , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/53 , C07D513/04 , A61P9/12 , A61P9/10 , A61P15/10
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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公开(公告)号：US20070238741A1
公开(公告)日：2007-10-11
申请号：US11733045
申请日：2007-04-09
申请人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： A61K31/519 , A61P25/00 , C07D491/00
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物的合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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![Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors](/abs-image/US/2010/01/19/US07648986B2/abs.jpg.150x150.jpg)
公开(公告)号：US07648986B2
公开(公告)日：2010-01-19
申请号：US11733045
申请日：2007-04-09
申请人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： C07D495/04 , C07D251/16 , C07D413/10 , A61K31/519 , A61K31/5377 , A61K31/53 , A61K31/497 , A61K31/496 , A61K31/498 , A61P9/12 , A61P9/10 , A61P35/04 , A61P11/06 , C07D401/12 , C07D401/14
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物的合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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8.发明申请Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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9.发明授权Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号：US08076488B2
公开(公告)日：2011-12-13
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： C07D213/62 , C07D401/00 , C07D417/00
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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