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    ANTIPSYCHOTIC AGENTS AND STANDARDIZED ANTIPSYCHOTIC FRACTIONS FROM RAUWOLFIA TETRAPHYLLA AND PROCESS OF THEIR ISOLATION
    1.
    发明申请
    ANTIPSYCHOTIC AGENTS AND STANDARDIZED ANTIPSYCHOTIC FRACTIONS FROM RAUWOLFIA TETRAPHYLLA AND PROCESS OF THEIR ISOLATION 有权
    来自RAUWOLFIA TETRAPHYLLA的抗菌药物和标准化抗肿瘤药物及其分离方法

    公开(公告)号：US20120184576A1

    公开(公告)日：2012-07-19

    申请号：US13262040

    申请日：2010-03-31

    申请人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

    发明人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

    IPC分类号： A61K31/4375 ,  C07D455/00 ,  A61P25/18 ,  A61K31/475

    CPC分类号： A61K36/24

    摘要： The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-derαethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 1. R1=R2=OMe R3=β-H (Isoreserpiline) 2. R1=R2=OMe R3=β-H (Reserpiline) ″3. R1=OMe R2=HR3=β-H (11-Demethoxy reserpiline) ″4.R1=H R2=OMe R3=β-H (10-Demethoxy reserpiline) ″5. R1=R2=H R3=α-H (Tetrahydroalstonine) *7. R1=OMe R2=H R3=α-H (10-Methoxytetrahudroalstonine).

    摘要翻译： 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱中的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异丙基苯胺，10-脱乙氧基去甲苯胺，11-去甲氧基甲苯吡胺，储存蛋白和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自罗非草（Rauwolfia tetraphylla）的叶子的式1和2的烷烃的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。 R1 = R2 = OMe R3 =＆bgr; -H（Isoreserpiline）2.R1 = R2 = OMe R3 =＆bgr; -H（Reserpiline）“3。 R1 = OMe R2 = HR3 =＆bgr; -H（11-甲氧基乙酰胺）“4.R1 = H R2 = OMe R3 =＆bgr; -H（10-甲氧基乙胺） R1 = R2 = H R3 =α-H（四氢奥斯汀）* 7。 R1 = OMe R2 = H R3 =α-H（10-甲氧基四胡司汀）。

    Systems, methods and software for adjusting read data from utility meters
    9.
    发明授权
    Systems, methods and software for adjusting read data from utility meters 有权
    用于调整公用仪表读取数据的系统，方法和软件

    公开(公告)号：US08620885B1

    公开(公告)日：2013-12-31

    申请号：US12706041

    申请日：2010-02-16

    申请人： Anil Kumar Gupta ,  David James Hubbard ,  Jerome Frank Winzig

    发明人： Anil Kumar Gupta ,  David James Hubbard ,  Jerome Frank Winzig

    IPC分类号： G06F17/00

    CPC分类号： G06Q10/04 ,  G06Q50/06

    摘要： Many public utilities companies employ meter data management systems (MDMSs) to manage the millions and sometimes billions of daily and interval meter read values that they collect during a single billing period. One problem with some MDMSs estimate missing daily reads based on average daily usage and these estimates do not match daily usage values determined from interval read data, causing sum check exceptions. Such exceptions are undesirable because they can lead to billing errors and lost consumer confidence in the utility, among other things. To address this, the present inventors devised an exemplary system that uses good and estimated interval read data to more accurately estimate the missing daily reads and thereby reduce occurrences of sum check exceptions. The exemplary system also estimates missing time of use and demand data based on interval read data.

    摘要翻译： 许多公用事业公司采用仪表数据管理系统（MDMS）来管理在单个计费周期内收集的数百万甚至数十亿的每日和间隔表读取值。 一些MDMS的一个问题是根据平均每日使用量估计缺少每日读数，这些估计值与从间隔读取数据确定的日常使用值不符，导致总和检查异常。 这种例外是不合需要的，因为它们可能导致计费错误，并导致消费者对公用事业的信心。 为了解决这个问题，本发明人设计了一种示例性系统，其使用良好和估计的间隔读取数据来更准确地估计丢失的每日读取，从而减少和检查异常的发生。 示例性系统还基于间隔读取数据估计丢失使用时间和需求数据。

    NOVEL HERBAL OIL FOR CONTROLLING BLOOD SUGAR WITHOUT RISK OF HYPOGLYCEMEA
    10.
    发明申请
    NOVEL HERBAL OIL FOR CONTROLLING BLOOD SUGAR WITHOUT RISK OF HYPOGLYCEMEA 审中-公开
    用于控制血糖的新型草药油，没有高血糖风险

    公开(公告)号：US20130203711A1

    公开(公告)日：2013-08-08

    申请号：US13821016

    申请日：2011-10-04

    申请人： Anil Kumar Gupta

    发明人： Anil Kumar Gupta

    IPC分类号： A61K31/618 ,  A61K31/045

    CPC分类号： A61K31/618 ,  A61K31/045 ,  A61K31/60 ,  A61K36/15 ,  A61K36/185 ,  A61K36/45 ,  A61K36/61 ,  A61K36/63 ,  A61K36/738 ,  A61K2300/00

    摘要： The invention relates to a herbal oil, for controlling blood sugar without risk of hypoglycemia, comprising of the step of (i) fractional distillation of essential oils comprising of turpentine oil, jasmine oil, rose oil, eucalyptus oil, sandal wood oil and water green oil to obtain hydroxyl compounds #-terpinol, linalool, Gereneol, Citroneoll, #-Santalol, Methyl salicylate and other alcoholic terpenoils and (ii) dilution with fat oil so as to have approximate weight percentage of #-terpinol 50%, linalool 6%, Gereneol 4%, Citroneoll 3.5%, #-Santalol 2.7%, Methyl salicylate 2%, other alcoholic terpenoils and fat oil 31.8%.

    摘要翻译： 本发明涉及一种用于控制没有低血糖风险的血糖的草药油，其包括以下步骤：（i）将包含松节油，茉莉油，玫瑰油，桉树油，凉鞋木油和水绿色的精油分馏 油，得到羟基化合物＃-terpinol，芳樟醇，Gereneol，Citroneoll，＃-Santalol，水杨酸甲酯和其他酒精萜烯，和（ii）用脂肪油稀释，使其约占重量百分比为#-固辛醇50％，芳樟醇6％ ，Gereneol 4％，Citroneoll 3.5％，＃-Santalol 2.7％，水杨酸甲酯2％，其他酒精萜烯和脂肪油31.8％。