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公开(公告)号：US20110195494A1
公开(公告)日：2011-08-11
申请号：US12894947
申请日：2010-09-30
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/22 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： DII4-binding molecules, preferably DII4-binding immunoglobulin single variable domains like VHHs and VHs, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with DII4-mediated effects on angiogenesis. Bispecific DII4-binding molecules that also bind to VEGF-A. Nucleic acids encoding DII4-binding molecules, host cells and methods for preparing same.
摘要翻译： DII4结合分子，优选DII4结合免疫球蛋白单可变结构域如VHH和VH，含有它们的药物组合物及其在治疗与DII4介导的对血管发生的作用相关的疾病中的用途。 也与VEGF-A结合的双特异性DII4结合分子。 编码DII4结合分子的核酸，宿主细胞及其制备方法。
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2.发明授权CX3CR1-binding polypeptides comprising immunoglobulin single variable domains 有权包含免疫球蛋白单可变结构域的CX3CR1结合多肽公开(公告)号：US09035029B2
公开(公告)日：2015-05-19
申请号：US13775307
申请日：2013-02-25
申请人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
发明人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C12N15/09 , C12N15/11 , C12N15/63
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
摘要翻译： 本发明涉及CX3CR1结合多肽，特别是涉及包含特异性免疫球蛋白结构域的多肽。 本发明还涉及编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 包含这样的多肽的组合物; 以及这些多肽或这种组合物的用途，特别是用于预防，治疗和诊断目的。
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公开(公告)号：US20140120095A1
公开(公告)日：2014-05-01
申请号：US13848826
申请日：2013-03-22
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和DII4结合组分。 含有它们的药物组合物及其在治疗与VEGF和DII4介导的血管生成作用相关的疾病中的用途。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20110172398A1
公开(公告)日：2011-07-14
申请号：US12894989
申请日：2010-09-30
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和Dll4结合组分。 含有该组合物的药物组合物及其用于治疗与VEGF和Dll4介导的血管生成作用相关的疾病。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20240279349A2
公开(公告)日：2024-08-22
申请号：US17836473
申请日：2022-06-09
申请人： Sanjaya Singh , Alisa Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Ververken
发明人： Sanjaya Singh , Alisa Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Ververken
IPC分类号： C07K16/28 , C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/00 , A61K39/395 , A61P13/12 , C07K14/52 , C07K14/715
CPC分类号： C07K16/2866 , C07H21/04 , C07K16/28 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/3955 , A61K2039/505 , A61P13/12 , C07K14/521 , C07K14/7158 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
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公开(公告)号：US20240026013A2
公开(公告)日：2024-01-25
申请号：US17836473
申请日：2022-06-09
申请人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
发明人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
IPC分类号： C07K16/28 , C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/395 , A61P13/12 , A61K39/00 , C07K14/715 , C07K14/52
CPC分类号： C07K16/2866 , C07K16/28 , C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/3955 , A61P13/12 , C07K2317/22 , C07K2317/569 , C07K2317/76 , C07K2317/92 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/52 , C07K2317/94 , C07K2319/00 , C07K14/7158 , C07K14/521 , C07K2317/565 , C07K2317/35 , C07K2319/30
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
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公开(公告)号：US20130224224A1
公开(公告)日：2013-08-29
申请号：US13775307
申请日：2013-02-25
申请人： Sanjaya SINGH , Alisa K. WATERMAN , Erik DEPLA , Toon LAEREMANS , Diane VAN HOORICK , Cedric Jozef Néotère VERVERKEN
发明人： Sanjaya SINGH , Alisa K. WATERMAN , Erik DEPLA , Toon LAEREMANS , Diane VAN HOORICK , Cedric Jozef Néotère VERVERKEN
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C12N15/09 , C12N15/11 , C12N15/63
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
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