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19 条记录 (耗时 0.021 秒)

    Ifosfamide lyophilizate preparations
    7.
    发明授权
    Ifosfamide lyophilizate preparations 失效
    异环磷酰胺冻干制剂

    公开(公告)号：US5750131A

    公开(公告)日：1998-05-12

    申请号：US752069

    申请日：1996-11-19

    申请人： Burkhard Wichert ,  Dieter Sauerbier ,  Jurgen Rawert

    发明人： Burkhard Wichert ,  Dieter Sauerbier ,  Jurgen Rawert

    IPC分类号： A61K9/19 ,  A61K31/675 ,  A61K47/10 ,  A61K47/18 ,  A61K47/36 ,  A61K47/38 ,  A61K9/00 ,  A61K31/715

    CPC分类号： A61K9/0019 ,  A61K31/675 ,  A61K47/183 ,  A61K9/19 ,  A61K47/10 ,  A61K47/36 ,  A61K47/38

    摘要： The invention relates to improved ifosfamide preparations which are distinguished in that as primary auxiliary a polysaccharide, in general a glycan, preferably dextran, starches or cellulose, in particular dextrans having an MW of 20,000 to 85,000, modified starches such as hydroxyethyl starch and chemically modified celluloses such as hydroxyethylcellulose and sodium carboxymethylcellulose, a glycol ether, preferably polyethylene glycol, in particular polyethylene glycols having a molecular weight of 600 to 6000 or an amino acid, preferably alanine, leucine or glutamic acid, is added to them. The improved ifosfamide preparation can also contain as an auxiliary a pharmaceutically customary buffer, for example acetate, citrate or tris buffer, preferably phosphate buffer. In addition, improved ifosfamide preparations are obtained by addition of NaHCO.sub.3. The ifosfamide preparations according to the invention can comprise one or a combination of several auxiliaries. Mesna can be added to the formulation as a uroprotector.

    摘要翻译： 本发明涉及改进的异环磷酰胺制剂，其特征在于作为主要助剂是多糖，通常为聚糖，优选葡聚糖，淀粉或纤维素，特别是具有20,000至85,000的MW的葡聚糖，改性淀粉如羟乙基淀粉和化学改性的 纤维素如羟乙基纤维素和羧甲基纤维素钠，二醇醚，优选聚乙二醇，特别是分子量为600至6000的聚乙二醇或氨基酸，优选丙氨酸，亮氨酸或谷氨酸。 改进的异环磷酰胺制剂还可以含有药学上常规的缓冲剂作为辅助剂，例如乙酸盐，柠檬酸盐或tris缓冲剂，优选磷酸盐缓冲液。 此外，通过加入NaHCO 3获得改进的异环磷酰胺制剂。 根据本发明的异环磷酰胺制剂可以包含一种或几种助剂的组合。 可将Mesna作为uroprotector加入制剂中。

    Tablets and granulates containing mesna as active substance
    8.
    发明授权
    Tablets and granulates containing mesna as active substance 失效
    含有mesna作为活性物质的片剂和颗粒

    公开(公告)号：US5252341A

    公开(公告)日：1993-10-12

    申请号：US930783

    申请日：1992-08-17

    申请人： Dieter Sauerbier ,  Jurgen Engel ,  Eckhard Milsmann

    发明人： Dieter Sauerbier ,  Jurgen Engel ,  Eckhard Milsmann

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/46 ,  A61K9/50 ,  A61K31/185 ,  A61K9/16

    CPC分类号： A61K9/0095 ,  A61K31/185 ,  A61K9/0007 ,  A61K9/2077 ,  A61K9/5026

    摘要： A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.

    摘要翻译： 含有mesna的颗粒是通过在醇，丙酮或其中之一与水的混合物存在下制粒美司钠制成的。 颗粒可以与其他药剂一起转化成片剂。 片剂含有0.01-1重量份的粘合剂0.03-0.4重量份的崩解剂0.01-0.2重量份的润滑剂和0.1-1重量份的填充剂，以及在 泡腾片剂，另外0.05-30重量份的常规生理上可接受的泡腾混合物。