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公开(公告)号：US09190255B2
公开(公告)日：2015-11-17
申请号：US13699721
申请日：2011-05-23
CPC分类号： H01J49/067 , H01J49/34 , H01J49/40 , H01J49/425 , H01J49/426
摘要： A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
摘要翻译： 质谱仪包括用于在第一真空室中产生离子脉冲的离子脉冲装置，用于在第二真空室中接收和捕获用于质量分析的离子脉冲的离子阱装置，以及布置在离子脉冲装置和离子脉冲装置之间的离子 - 光学透镜装置 用于接收离子脉冲并将离子从该离子阱输出到离子阱装置的离子阱装置。 第一透镜电极和第二透镜电极共同限定光轴并且适于在其上分布第一电位和第二电位。 透镜控制装置随时间变化，相对于第二电位的第一电位随着时间而变化，以便控制离子质量 - 荷电比例，其已经穿过离子光学透镜装置的离子的动能。 这可以控制离子阱从离子光学透镜装置接收的离子的质量范围。
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公开(公告)号：US08610054B2
公开(公告)日：2013-12-17
申请号：US13318317
申请日：2010-04-30
CPC分类号： G01N27/624
摘要： The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyzer, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field.
摘要翻译： 本发明涉及用于进行差示离子迁移率分析和质量分析的离子分析装置。 在实施例中，该装置包括位于质量分析器之前的质谱仪的真空封壳中的差分离子迁移率装置，其中该装置的泵送系统构造成为差压器提供0.005kPa至40kPa的操作压力 离子迁移率器件，并且其中该器件包括提供50kHz至25MHz的频率波形的数字非对称波形发生器。 示例显示出优异的分辨能力和离子透过率。 离子迁移率装置可以是多极，例如，除了偶极场之外，通过将四极场施加到装置可以实现12极和径向离子聚焦。
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公开(公告)号：US20120056085A1
公开(公告)日：2012-03-08
申请号：US13318317
申请日：2010-04-30
CPC分类号： G01N27/624
摘要： The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyser, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field.
摘要翻译： 本发明涉及用于进行差示离子迁移率分析和质量分析的离子分析装置。 在实施例中，该装置包括位于质量分析器之前的质谱仪的真空封壳中的差分离子迁移率装置，其中该装置的泵送系统构造成为差压器提供0.005kPa至40kPa的操作压力 离子迁移率器件，并且其中该器件包括提供50kHz至25MHz的频率波形的数字非对称波形发生器。 示例显示出优异的分辨能力和离子透过率。 离子迁移率装置可以是多极，例如，除了偶极场之外，通过将四极场施加到装置可以实现12极和径向离子聚焦。
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公开(公告)号：US20130068944A1
公开(公告)日：2013-03-21
申请号：US13699721
申请日：2011-05-23
CPC分类号： H01J49/067 , H01J49/34 , H01J49/40 , H01J49/425 , H01J49/426
摘要： A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
摘要翻译： 质谱仪包括用于在第一真空室中产生离子脉冲的离子脉冲装置，用于在第二真空室中接收和捕获用于质量分析的离子脉冲的离子阱装置，以及布置在离子脉冲装置和离子脉冲装置之间的离子 - 光学透镜装置 用于接收离子脉冲并将离子从该离子阱输出到离子阱装置的离子阱装置。 第一透镜电极和第二透镜电极共同限定光轴并且适于在其上分布第一电位和第二电位。 透镜控制装置随时间变化，相对于第二电位的第一电位随着时间而变化，以便控制离子质量 - 荷电比例，其已经穿过离子光学透镜装置的离子的动能。 这可以控制离子阱从离子光学透镜装置接收的离子的质量范围。
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公开(公告)号：US08198582B2
公开(公告)日：2012-06-12
申请号：US12308456
申请日：2007-06-14
CPC分类号： H01J49/424 , H01J49/0481 , H01J49/24
摘要： A method of pulsing gas in a quadrupole ion trap to reduce excess internal energy of ions formed externally to the trap at high-vacuum conditions by laser desoprtion is disclosed. With pulsed gas introduction, pressures greater than those under which traps are normally operated can be achieved over a few milliseconds. Under these elevated pressure transients, the process of translational cooling is accelerated and ions undergo thermalized collisions before dissociation occurs. Minimization of uncontrolled fragmentation (thermalization) and enhanced sensitivity are observed at pressures exceeding a threshold of about 1 mTorr.
摘要翻译： 公开了一种在四极离子阱中脉冲气体的方法，以通过激光去除在高真空条件下减少在阱外部形成的离子的过量内部能量。 在脉冲气体引入下，可以在几毫秒内实现大于陷阱正常工作的压力的压力。 在这些升高的压力瞬变下，平移冷却过程加速，离子发生之前发生热化碰撞。 在超过约1mTorr的压力的压力下观察到不受控制的碎裂（热化）和增强的灵敏度的最小化。
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公开(公告)号：US20100270465A1
公开(公告)日：2010-10-28
申请号：US12308456
申请日：2007-06-14
CPC分类号： H01J49/424 , H01J49/0481 , H01J49/24
摘要： A method of pulsing gas in a quadrupole ion trap to reduce excess internal energy of ions formed externally to the trap at high-vacuum conditions by laser desoprtion is disclosed. With pulsed gas introduction, pressures greater than those under which traps are normally operated can be achieved over a few milliseconds. Under these elevated pressure transients, the process of translational cooling is accelerated and ions undergo thermalized collisions before dissociation occurs. Minimization of uncontrolled fragmentation (thermalization) and enhanced sensitivity are observed at pressures exceeding a threshold of about 1 mTorr.
摘要翻译： 公开了一种在四极离子阱中脉冲气体的方法，以通过激光去除在高真空条件下减少在阱外部形成的离子的过量内部能量。 在脉冲气体引入下，可以在几毫秒内实现大于陷阱正常工作的压力的压力。 在这些升高的压力瞬变下，平移冷却过程加速，离子发生之前发生热化碰撞。 在超过约1mTorr的压力的压力下观察到不受控制的碎裂（热化）和增强的灵敏度的最小化。
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