公开(公告)号：US20190021321A1

公开(公告)日：2019-01-24

申请号：US16070351

申请日：2017-02-28

Applicant: Dinesh AGGARWAL

Inventor： Dinesh AGGARWAL

IPC: A01N37/44 ,  A01N31/02 ,  A61L29/16

Abstract: To reduce problems associated with clotting and thrombus formation, it is now common to “lock” intravascular access catheters between successive uses. Locking typically involves first flushing the catheter with saline to remove blood and other substances from the catheter lumen. After the catheter has been flushed, an anti-coagulant solution is injected to displace the saline and fill the lumen. Use of an effective antimicrobial substance along with anticoagulant during the same process is important to reduce the possibility of bacterial contamination and subsequent infection. The present invention deals with a safe, effective and economical catheter lock flush solution with excellent antimicrobial and anticoagulant activity. The unique ratio of the active components of the catheter lock solution used in the invention i.e. Sodium salt(s) of EDTA, Ethanol and D-mannitol with a suitable pH ensures broad-spectrum antimicrobial and optimum anticoagulant activity.

公开(公告)号：US20100256576A1

公开(公告)日：2010-10-07

申请号：US12755550

申请日：2010-04-07

Applicant: Dinesh Aggarwal ,  Chirag B. Shah

Inventor： Dinesh Aggarwal ,  Chirag B. Shah

IPC: A61L29/16 ,  A61K31/235 ,  A61P33/02 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P31/00

CPC classification number: A61K31/235

Abstract: Disinfectant compositions including EDTA salt(s), Parabens and Methylene Blue. The disinfectant compositions have demonstrated activity as enhanced, fast acting catheter lock/flush solutions. They are safe for human and medical uses and may be used as prophylactic preparations to prevent infection, or to reduce the proliferation of and/or eliminate existing or established infections. In addition, the composition has anticoagulant activity and can be utilized to maintain the patency of catheters.

Abstract translation: 消毒剂组合物，包括EDTA盐，对羟基苯甲酸酯和亚甲基蓝。 消毒剂组合物已经证明了作为增强的快速作用的导管锁/冲洗溶液的活性。 它们对于人类和医学用途是安全的，并且可以用作预防性制剂以预防感染，或减少增殖和/或消除现有或已建立的感染。 此外，该组合物具有抗凝血活性并且可用于维持导管通畅。

公开(公告)号：US20130190705A1

公开(公告)日：2013-07-25

申请号：US13552060

申请日：2012-07-18

Applicant: Mark A. Vess ,  Dinesh Aggarwal

Inventor： Mark A. Vess ,  Dinesh Aggarwal

IPC: A61F13/00

CPC classification number: A61F13/00068 ,  A61M1/0023 ,  A61M1/0052 ,  A61M1/0088 ,  A61M27/00

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound includes a wound dressing adapted for positioning relative to a wound bed and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism includes a housing; a vacuum source in the housing and associated with a vacuum port; a collection canister defining an internal chamber in fluid communication with the vacuum source through the vacuum port and with the wound dressing for collecting exudates removed from the wound bed; a hydrophobic filter in fluid communication with the vacuum source and the internal chamber of the collection canister; and a screen disposed proximally of the filter. The filter is adapted to prevent exudates from reaching the vacuum source while allowing passage of air to the vacuum source.

Abstract translation: 与伤口愈合有关的低于大气压力治疗的系统包括适于相对于伤口床定位的伤口敷料和低于大气压的压力机构。 低于大气压的压力机构包括壳体; 壳体中的真空源并与真空端口相关联; 限定通过真空端口与真空源流体连通的内部室的收集罐和用于收集从伤口床移除的渗出物的伤口敷料; 与真空源和收集罐的内部腔室流体连通的疏水过滤器; 以及设置在过滤器近侧的屏幕。 过滤器适于防止渗出物到达真空源，同时允许空气通过真空源。

公开(公告)号：US20090170947A1

公开(公告)日：2009-07-02

申请号：US12347082

申请日：2008-12-31

Applicant: Dinesh Aggarwal ,  Chirag Shah

Inventor： Dinesh Aggarwal ,  Chirag Shah

IPC: A61K31/197

CPC classification number: A01N47/44 ,  A01N25/02 ,  A01N37/44 ,  A01N2300/00

Abstract: Disinfectant compositions comprising PHMB and EDTA salt(s) are disclosed. The disinfectant compositions have also demonstrated activity as enhanced, fast acting catheter lock/flush solutions. They are safe for human and medical uses and may be used as prophylactic preparations to prevent infection, or to reduce the proliferation of and/or eliminate existing or established infections.

Abstract translation: 公开了包含PHMB和EDTA盐的消毒剂组合物。 消毒剂组合物还证明了作为增强的快速作用的导管锁/冲洗溶液的活性。 它们对于人类和医学用途是安全的，并且可以用作预防性制剂以预防感染，或减少增殖和/或消除现有或已建立的感染。

公开(公告)号：US20100022652A1

公开(公告)日：2010-01-28

申请号：US12489669

申请日：2009-06-23

Applicant: Dinesh Aggarwal ,  Chirag B. Shah

Inventor： Dinesh Aggarwal ,  Chirag B. Shah

IPC: A61K31/198 ,  A61P7/02 ,  A61P31/04

CPC classification number: A01N37/46 ,  A61K31/198 ,  A01N37/44 ,  A01N2300/00 ,  A61K2300/00

Abstract: A composition may include a combination of at least one chelating agent and at least one antioxidant agent, the combination may have a fractional inhibitory concentration coefficient of about 0.5 or less and/or an INR of > about 2.82.

Abstract translation: 组合物可以包括至少一种螯合剂和至少一种抗氧化剂的组合，该组合可以具有约0.5或更小的分数抑制浓度系数和/或约2.82的INR。

公开(公告)号：US20090170932A1

公开(公告)日：2009-07-02

申请号：US12347073

申请日：2008-12-31

Applicant: Dinesh AGGARWAL ,  Chirag Shah

Inventor： Dinesh AGGARWAL ,  Chirag Shah

IPC: A61K31/375 ,  A61L2/18

CPC classification number: A61K31/375 ,  A01N41/12 ,  A61L2/18 ,  A61L12/14 ,  A01N43/08 ,  A01N2300/00

Abstract: Disinfectant compositions comprising N-Acetyl Cysteine (NAC) and Vitamin C are disclosed. The disinfectant compositions have also demonstrated activity in inhibiting as well as killing micro-organisms responsible for generating biofilms. They are safe for human and medical uses and may be used as prophylactic preparations to reduce the proliferation of and/or eliminate existing or established infections.

Abstract translation: 公开了包含N-乙酰半胱氨酸（NAC）和维生素C的消毒剂组合物。 消毒剂组合物还显示了抑制和杀死负责产生生物膜的微生物的活性。 它们对于人类和医学用途是安全的，并且可以用作预防剂，以减少现有或已建立的感染的增殖和/或消除现有或已建立的感染。

公开(公告)号：US20110106027A1

公开(公告)日：2011-05-05

申请号：US12893257

申请日：2010-09-29

Applicant: Mark A. Vess ,  Dinesh Aggarwal

Inventor： Mark A. Vess ,  Dinesh Aggarwal

IPC: A61M1/00

CPC classification number: A61F13/00068 ,  A61M1/0023 ,  A61M1/0052 ,  A61M1/0088 ,  A61M27/00

Abstract: A system for subatmospheric pressure therapy in connection with healing a surgical or chronic wound includes a wound dressing adapted for positioning relative to a wound bed of a subject and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism includes a housing; a vacuum source disposed in the housing and associated with a vacuum port; a collection canister defining an internal chamber in fluid communication with the vacuum source through the vacuum port and with the wound dressing for collecting exudates removed from the wound bed under influence of the vacuum source; a hydrophobic filter in fluid communication with the vacuum source and the internal chamber of the collection canister; and a screen disposed proximally of the filter. The filter is adapted to prevent exudates from reaching the vacuum source while allowing passage of air to the vacuum source. The screen includes compounds for cleaving proteins in the exudates to prevent clogging of the filter by the exudates in the collection canister.

Abstract translation: 与治疗外科或慢性伤口相关的低于大气压的治疗系统包括适于相对于受试者的伤口床和低于大气压的压力机构定位的伤口敷料。 低于大气压的压力机构包括壳体; 设置在壳体中并与真空端口相关联的真空源; 限定通过真空端口与真空源流体连通的内部室的收集罐和用于收集在真空源影响下从伤口床排出的渗出物的伤口敷料; 与真空源和收集罐的内部腔室流体连通的疏水过滤器; 以及设置在过滤器近侧的屏幕。 过滤器适于防止渗出物到达真空源，同时允许空气通过真空源。 屏幕包括用于在渗出物中切割蛋白质的化合物，以防止过滤器被收集罐中的渗出物堵塞。