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    Porphyrin derivatives
    4.
    发明授权
    Porphyrin derivatives 失效
    卟啉衍生物

    公开(公告)号：US07019132B2

    公开(公告)日：2006-03-28

    申请号：US10718734

    申请日：2003-11-20

    申请人： Nam-Tae Woo ,  Min-Suk Kang ,  Won-Young Lee ,  Chang-Hee Lee ,  Yong-Rok Kim ,  Dai-Woon Lee ,  Dong-Hoon Won ,  Si-Hwan Ko

    发明人： Nam-Tae Woo ,  Min-Suk Kang ,  Won-Young Lee ,  Chang-Hee Lee ,  Yong-Rok Kim ,  Dai-Woon Lee ,  Dong-Hoon Won ,  Si-Hwan Ko

    IPC分类号： C07B47/00

    CPC分类号： A61K41/0071 ,  A61K31/409 ,  A61K31/555 ,  A61K49/0036 ,  C07D487/22

    摘要： The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing singlet state oxygen radical and the inventive compounds have superior advantages such as excellent photon yield to produce singlet oxygen, good physical stability and potent cell cytotoxicity to conventional photosensitizer. The present invention also provides a pharmaceutical composition comprising a novel photopyrin compound of formula (I) to (VII) or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating various cancers such as stomach cancer, liver cancer, lung cancer, cervical cancer and breast cancer in human or mammal together with a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及通过再现单线态氧自由基用作抗癌剂或光动力学诊断剂的新型光解吡啶化合物及其药学上可接受的盐，并且本发明化合物具有优异的优点，例如优异的光子产率以产生单线态氧，良好的物理 稳定性和对常规光敏剂有效的细胞毒性。 本发明还提供一种药物组合物，其包含式（I）至（VII）的新颖吡嘧啶化合物或其药学上可接受的盐作为预防或治疗各种癌症如胃癌，肝癌，肺癌，子宫颈癌的活性成分 人或哺乳动物的癌症和乳腺癌以及药学上可接受的载体。