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公开(公告)号:US07396914B2
公开(公告)日:2008-07-08
申请号:US10911838
申请日:2004-08-04
申请人: Donna Ambrosino , Hector Hernandez , Thomas Greenough , Katherine Luzuriaga , Mohan Somasundaran , Gregory J. Babcock , William D. Thomas, Jr. , John Sullivan
发明人: Donna Ambrosino , Hector Hernandez , Thomas Greenough , Katherine Luzuriaga , Mohan Somasundaran , Gregory J. Babcock , William D. Thomas, Jr. , John Sullivan
CPC分类号: A61K39/215 , A01K2267/01 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/505 , A61K2039/55566 , C07H21/04 , C07K14/005 , C07K16/10 , C07K2317/21 , C07K2317/34 , C12N2770/20022 , C12N2770/20034 , C12Q1/701 , G01N33/56983 , G01N2333/165
摘要: Codon-optimized nucleic acids, polypeptides, and antibodies are described herein.
摘要翻译: 密码子优化的核酸,多肽和抗体在本文中描述。
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公开(公告)号:US09109037B2
公开(公告)日:2015-08-18
申请号:US13882017
申请日:2011-10-25
申请人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
发明人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
IPC分类号: A61K39/395 , C07K16/40 , A61K45/06 , A61K39/00
CPC分类号: C07K16/40 , A61K31/428 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
摘要翻译: 本发明的特征在于抗SOD1抗体和使用该抗体治疗肌萎缩性侧索硬化(ALS)或改善与ALS相关的症状的方法。
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公开(公告)号:US20120288508A1
公开(公告)日:2012-11-15
申请号:US13490757
申请日:2012-06-07
申请人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
发明人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US07625559B2
公开(公告)日:2009-12-01
申请号:US11051453
申请日:2005-02-04
申请人: Donna Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
发明人: Donna Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US20050287150A1
公开(公告)日:2005-12-29
申请号:US11051453
申请日:2005-02-04
申请人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Robert Graziano , Hector Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William Thomas , Hui-Fen Zhang
发明人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Robert Graziano , Hector Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William Thomas , Hui-Fen Zhang
IPC分类号: A61K39/40 , A61K47/64 , C07H21/04 , C07K16/12 , C12N5/06 , G01N33/554 , G01N33/569
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US20140044722A1
公开(公告)日:2014-02-13
申请号:US13882017
申请日:2011-10-25
申请人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
发明人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
IPC分类号: C07K16/40 , A61K45/06 , A61K39/395
CPC分类号: C07K16/40 , A61K31/428 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
摘要翻译: 本发明的特征在于抗SOD1抗体和使用该抗体治疗肌萎缩性侧索硬化(ALS)或改善与ALS相关的症状的方法。
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公开(公告)号:US20100233181A1
公开(公告)日:2010-09-16
申请号:US12533501
申请日:2009-07-31
申请人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
发明人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US20050069869A1
公开(公告)日:2005-03-31
申请号:US10911838
申请日:2004-08-04
申请人: Donna Ambrosino , Hector Hernandez , Thomas Greenough , Katherine Luzuriaga , Mohan Somasundaran , Gregory Babcock , William Thomas , John Sullivan
发明人: Donna Ambrosino , Hector Hernandez , Thomas Greenough , Katherine Luzuriaga , Mohan Somasundaran , Gregory Babcock , William Thomas , John Sullivan
IPC分类号: A61K38/00 , A61K39/00 , A61K39/215 , C07H21/04 , C07K14/165 , C07K16/10 , C12Q1/70 , G01N33/569 , C12N15/86
CPC分类号: A61K39/215 , A01K2267/01 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/505 , A61K2039/55566 , C07H21/04 , C07K14/005 , C07K16/10 , C07K2317/21 , C07K2317/34 , C12N2770/20022 , C12N2770/20034 , C12Q1/701 , G01N33/56983 , G01N2333/165
摘要: Codon-optimized nucleic acids, polypeptides, and antibodies are described herein.
摘要翻译: 密码子优化的核酸,多肽和抗体在本文中描述。
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公开(公告)号:US20100233182A1
公开(公告)日:2010-09-16
申请号:US12533552
申请日:2009-07-31
申请人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
发明人: Donna AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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