利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.011 秒)

    Intravascular apparatus method
    1.
    发明授权
    Intravascular apparatus method 失效
    血管内装置和方法

    公开(公告)号：US06569688B2

    公开(公告)日：2003-05-27

    申请号：US09486362

    申请日：2000-02-28

    申请人： Sarit Sivan ,  Uri Dinnar ,  Noah Lotan

    发明人： Sarit Sivan ,  Uri Dinnar ,  Noah Lotan

    IPC分类号： G01N33543

    CPC分类号： A61K9/0024 ,  A61F2/82 ,  A61F2/88 ,  A61F2250/0067 ,  A61K38/446 ,  A61K38/49 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  C12N9/0002

    摘要： Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier (2) for insertion into the vessel; and a biologically active agent (8) immobilized to the carrier (2), said biologically active agent (8) reacting with a first substance to produce a second substance. The second substance is preferably a therapeutic agent, such as nitric oxide, for locally treating the vessel. The biologically active agent (8) is preferably an enzyme such as nitrogen oxide synthase, and the first substance is preferably arginine introduced to the patient's body as part of a diet. According to another embodiment, the biologically active agent (8) is a catalytic antibody and the first substance is a prodrug. Alternatively, the biologically active agent (8) is a ribozyme. The method includes introducing into a patient's vessel an implantable carrier including a biologically active agent immobilized thereto, and reacting the biologically active agent with a first substance to locally produce a second substance.

    摘要翻译： 提供了用于局部治疗患者血管的血管内装置和方法。 该装置包括用于插入容器的植入载体（2） 和固定在载体（2）上的生物活性剂（8），所述生物活性剂（8）与第一物质反应产生第二物质。 第二物质优选是用于局部处理血管的治疗剂，例如一氧化氮。 生物活性剂（8）优选为诸如氮氧化物合酶的酶，并且第一物质优选作为饮食的一部分引入到患者身体中的精氨酸。 根据另一个实施方案，生物活性剂（8）是催化抗体，第一种物质是前药。 或者，生物活性剂（8）是核酶。 该方法包括向患者的血管内引入可植入载体，其包含固定在其上的生物活性剂，并使生物活性剂与第一物质反应以局部产生第二物质。