公开(公告)号：US08895054B2

公开(公告)日：2014-11-25

申请号：US12411855

申请日：2009-03-26

申请人： Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

发明人： Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K31/685 ,  A61L27/50

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/685 ,  A61L27/50 ,  A61L2430/24

摘要： The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C15 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints.

摘要翻译： 本发明涉及联合润滑和/或预防软骨磨损的方法，其使用具有至少一种磷脂（PL）的脂质体的脂质体，所述磷脂由具有两个相同或不同的C12-脂肪酸的甘油磷脂（GPL）组成， C16烃链和具有C12-C18烃链的鞘脂（SPL），所述一种或多种膜具有其中发生固体有序（SO）至液体无序（LD）相变的相变温度，相转变温度在 温度为约20℃至约39℃，用于润滑接头。

公开(公告)号：US20090155345A1

公开(公告)日：2009-06-18

申请号：US12096652

申请日：2006-12-07

申请人： Yechezkel Barenholz ,  Avi Schroeder ,  Joseph Kost

发明人： Yechezkel Barenholz ,  Avi Schroeder ,  Joseph Kost

IPC分类号： A61K9/127 ,  B01J13/02

CPC分类号： A61K41/0028 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1277

摘要： The present invention provides methods for loading of agents and substances into per-formed liposomes, preferably a suspension of pre-formed liposomes as well as to methods for the controlled quantum (step-wise) release of agents and substances from liposomes. One of the principle features of the methods of the invention is to expose the liposomes to ultrasound irradiation having predefined parameters, resulting in an increase in permeability of the liposomes, thereby permitting, respectively, the loading and/or release of agents and substances into and/or from the liposomes.

摘要翻译： 本发明提供了将试剂和物质装载到成形的脂质体中，优选预先形成的脂质体的悬浮液以及从脂质体中受控量子（逐步）释放试剂和物质的方法。 本发明方法的主要特征之一是将脂质体暴露于具有预定参数的超声辐照，导致脂质体的渗透性增加，从而分别允许试剂和物质的加载和/或释放进入和 /或从脂质体。

公开(公告)号：US20130142863A1

公开(公告)日：2013-06-06

申请号：US13704866

申请日：2011-06-16

申请人： Jacob Klein ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

发明人： Jacob Klein ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61L27/50 ,  A61L2400/10 ,  A61L2430/24

摘要： The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

摘要翻译： 本发明提供了一种用于润滑一个或多个表面的方法，包括将凝胶相脂质体施加到所述一个或多个表面上，其中润滑时所述表面的温度低于所述脂质体的相变温度Tm。 该方法可用于润滑非生物表面，也可用于润滑哺乳动物受试者的生物组织的表面，例如用于治疗关节功能障碍。

公开(公告)号：US20230080018A1

公开(公告)日：2023-03-16

申请号：US17984761

申请日：2022-11-10

申请人： Jacob KLEIN et al. ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

发明人： Jacob KLEIN et al. ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

IPC分类号： A61K9/127 ,  A61L27/50

摘要： The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.