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    Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins
    4.
    发明申请
    Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins 审中-公开
    使用靶向表达toll样受体蛋白的细胞进行治疗和诊断的方法

    公开(公告)号：US20050281813A1

    公开(公告)日：2005-12-22

    申请号：US11185567

    申请日：2005-07-19

    申请人： Douglas Dedera ,  Peter Emtage

    发明人： Douglas Dedera ,  Peter Emtage

    IPC分类号： A61K38/17 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K38/177 ,  C07K16/2896

    摘要： Certain cells, including types of cancer cells such as B-cell lymphomas, T cell lymphomas, Hodgkin's disease and myeloid leukemias, are capable of expressing Toll-like Receptor 9 (TLR9) or Toll-like Receptor 10 (TLR10) mRNA. Immunotargeting using TLR9 or TLR10 polypeptides, nucleic acids encoding for TLR9 or TLR10 polypeptides and anti-TLR9 or anti-TLR10 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the TLR9 or TLR10 protein. Methods of immunotherapy and diagnosis of disorders associated with TLR9 or TLR10 protein-expressing cells, such as B-cell lymphoma, T cell lymphoma, acute myeloid leukemia, Hodgkin's disease, B cell leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia and myelodysplastic syndromes, are described.

    摘要翻译： 某些细胞，包括癌细胞如B细胞淋巴瘤，T细胞淋巴瘤，霍奇金病和骨髓性白血病的类型能够表达Toll样受体9（TLR9）或Toll样受体10（TLR10）mRNA。 使用TLR9或TLR10多肽的免疫靶向，编码TLR9或TLR10多肽的核酸和抗TLR9或抗TLR10抗体提供了杀死或抑制表达TLR9或TLR10蛋白的癌细胞生长的方法。 B细胞淋巴瘤，T细胞淋巴瘤，急性骨髓性白血病，霍奇金病，B细胞白血病，慢性淋巴细胞性白血病，慢性骨髓性白血病和骨髓增生异常综合征的TLR9或TLR10蛋白表达细胞相关疾病的免疫治疗和诊断方法， 被描述。