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公开(公告)号：US20080176759A1
公开(公告)日：2008-07-24
申请号：US11968078
申请日：2007-12-31
IPC分类号： C40B30/04
CPC分类号： C40B30/04 , C12Q1/18 , G01N33/54373 , G01N33/554 , G01N2500/00
摘要： Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by an aqueous film, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Arrays may be engineered to display natural membrane materials in a native fluid bilayer configuration, permitting high-throughput discovery of drugs that target and affect membrane components. The membrane-based assays detect binding events by monitoring binding-induced changes in one or more physical properties of fluid bilayers.
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公开(公告)号：US20060073514A1
公开(公告)日：2006-04-06
申请号：US10218325
申请日：2002-08-12
申请人： Douglas Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tang , Radoje Drmanac
发明人： Douglas Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tang , Radoje Drmanac
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
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公开(公告)号：US20090226960A1
公开(公告)日：2009-09-10
申请号：US10588937
申请日：2005-02-09
CPC分类号： C12N15/62 , C07K2319/02 , C07K2319/033 , C07K2319/035 , C07K2319/21
摘要： The present invention relates to a novel method of generating tethered extracellular or intracellular domains of transmembrane proteins using expression vectors. The invention also provides the expression vectors for use in the world.
摘要翻译： 本发明涉及使用表达载体产生跨膜蛋白的束缚细胞外或细胞内结构域的新方法。 本发明还提供了用于世界的表达载体。
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公开(公告)号：US20080248492A1
公开(公告)日：2008-10-09
申请号：US11968111
申请日：2007-12-31
IPC分类号： G01N33/566 , G01N33/68
CPC分类号： C40B30/04 , C12Q1/18 , G01N33/54373 , G01N33/554 , G01N2500/00
摘要： Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by an aqueous film, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Arrays may be engineered to display natural membrane materials in a native fluid bilayer configuration, permitting high-throughput discovery of drugs that target and affect membrane components. The membrane-based assays detect binding events by monitoring binding-induced changes in one or more physical properties of fluid bilayers.
摘要翻译： 公开了使用适用于生物传感器的表面检测器阵列器件的基于膜的测定。 该装置由具有限定由一个或多个双层阻挡区隔开的多个不同的双层兼容表面区域的表面的基板形成。 双层相容的表面区域承载它们，由水性膜分离，被支撑的液体双层。 双层可以含有选定的受体或生物分子。 主体水相覆盖基材表面上的双层。 阵列可以被设计成以天然流体双层结构显示天然膜材料，允许高通量发现靶向和影响膜组分的药物。 基于膜的测定通过监测流体双层的一种或多种物理性质中的结合诱导的变化来检测结合事件。
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公开(公告)号：US07407768B2
公开(公告)日：2008-08-05
申请号：US10661790
申请日：2003-09-11
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , C12Q1/18 , G01N33/54373 , G01N33/554 , G01N2500/00
摘要： Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by an aqueous film, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Arrays may be engineered to display natural membrane materials in a native fluid bilayer configuration, permitting high-throughput discovery of drugs that target and affect membrane components. The membrane-based assays detect binding events by monitoring binding-induced changes in one or more physical properties of fluid bilayers.
摘要翻译： 公开了使用适用于生物传感器的表面检测器阵列器件的基于膜的测定。 该装置由具有限定由一个或多个双层阻挡区隔开的多个不同的双层兼容表面区域的表面的基板形成。 双层相容的表面区域承载它们，由水性膜分离，被支撑的液体双层。 双层可以含有选定的受体或生物分子。 主体水相覆盖基材表面上的双层。 阵列可以被设计成以天然流体双层结构显示天然膜材料，允许高通量发现靶向和影响膜组分的药物。 基于膜的测定通过监测流体双层的一种或多种物理性质中的结合诱导的变化来检测结合事件。
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6.发明授权Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides 失效使用胰岛素样生长因子结合蛋白样多肽和多核苷酸的治疗和诊断方法公开(公告)号：US07109030B2
公开(公告)日：2006-09-19
申请号：US10218325
申请日：2002-08-12
申请人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
发明人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
IPC分类号： C12N15/00 , G01N33/53 , A61K38/00 , C07K14/435
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的IGFBP样多肽的突变体或其变体。 本发明的其它方面包括含有生产新型人分泌IGFBP样多肽的方法的载体，组合物，以及包括癌症在内的多肽的使用方法。
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