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公开(公告)号：US20060073514A1
公开(公告)日：2006-04-06
申请号：US10218325
申请日：2002-08-12
申请人： Douglas Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tang , Radoje Drmanac
发明人： Douglas Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tang , Radoje Drmanac
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
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公开(公告)号：US20050202422A1
公开(公告)日：2005-09-15
申请号：US10291128
申请日：2002-11-08
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
CPC分类号： C07K14/8107 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050175607A1
公开(公告)日：2005-08-11
申请号：US10220335
申请日：2001-02-26
申请人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
发明人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
CPC分类号： C07K14/47 , C12Q1/6886
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20070042392A1
公开(公告)日：2007-02-22
申请号：US11218141
申请日：2005-08-31
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/136
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050221342A1
公开(公告)日：2005-10-06
申请号：US10972024
申请日：2004-10-22
申请人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
发明人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
CPC分类号： C07K14/47 , C12Q1/6837
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20070049743A1
公开(公告)日：2007-03-01
申请号：US10294433
申请日：2002-11-13
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hung Chen , Feiyan Ren , Jian-Rui Wang , Tom Wehrman , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hung Chen , Feiyan Ren , Jian-Rui Wang , Tom Wehrman , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Ryle Goodrich
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050266423A1
公开(公告)日：2005-12-01
申请号：US11000463
申请日：2004-11-29
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Xiaohong Qian , Zhi Wang , Tom Wehrman , Jie Zhang , Ping Zhou , Yicheng Cao , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Xiaohong Qian , Zhi Wang , Tom Wehrman , Jie Zhang , Ping Zhou , Yicheng Cao , Radoje Drmanac
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/715 , C07K14/775 , C07K16/00 , C12N9/16 , C12N9/64 , C12P21/06 , C12Q1/68
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/715 , C07K14/775 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050239060A1
公开(公告)日：2005-10-27
申请号：US10122851
申请日：2002-04-12
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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9.发明申请Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein 审中-公开使用靶向表达杀伤细胞免疫球蛋白样受体样蛋白的细胞进行治疗和诊断的方法公开(公告)号：US20050208498A1
公开(公告)日：2005-09-22
申请号：US10727012
申请日：2003-12-02
申请人： Peter Emtage , Ping Zhou , Vinod Asundi , Y. Tang , Radoje Drmanac
发明人： Peter Emtage , Ping Zhou , Vinod Asundi , Y. Tang , Radoje Drmanac
IPC分类号： A61K38/00 , A61K39/395 , A61K47/48 , A61K51/00 , A61K51/10 , C07H21/02 , C07H21/04 , C07K14/705 , C07K16/28 , C07K16/30 , C07K16/46 , C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00 , A61K47/6849 , A61K48/00 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/34 , C07K2317/732 , C07K2317/77 , C07K2319/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N33/6872 , G01N2333/70503
摘要： Certain cells, including types of cancer cells such as KIRHy1, are capable of expressing KIRHy1 mRNA. Targeting using KIRHy1 polypeptides, nucleic acids encoding for KIRHy1 polypeptides and anti-KIRHy1 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy1 protein. Methods of therapy and diagnosis of disorders associated with KIRHy1 protein-expressing cells, such as B cell lymphoma, are described.
摘要翻译： 某些细胞，包括类型的癌细胞如KIRHy1，能够表达KIRHy1 mRNA。 使用KIRHy1多肽进行靶向，编码KIRHy1多肽的核酸和抗KIRHy1抗体提供了杀死或抑制表达KIRHy1蛋白的癌细胞生长的方法。 描述了与KIRHy1蛋白表达细胞如B细胞淋巴瘤相关的病症的治疗和诊断方法。
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10.发明授权Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides 失效使用胰岛素样生长因子结合蛋白样多肽和多核苷酸的治疗和诊断方法公开(公告)号：US07109030B2
公开(公告)日：2006-09-19
申请号：US10218325
申请日：2002-08-12
申请人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
发明人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
IPC分类号： C12N15/00 , G01N33/53 , A61K38/00 , C07K14/435
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的IGFBP样多肽的突变体或其变体。 本发明的其它方面包括含有生产新型人分泌IGFBP样多肽的方法的载体，组合物，以及包括癌症在内的多肽的使用方法。
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