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    Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins
    3.
    发明申请
    Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins 审中-公开
    使用靶向表达toll样受体蛋白的细胞进行治疗和诊断的方法

    公开(公告)号：US20050281813A1

    公开(公告)日：2005-12-22

    申请号：US11185567

    申请日：2005-07-19

    申请人： Douglas Dedera ,  Peter Emtage

    发明人： Douglas Dedera ,  Peter Emtage

    IPC分类号： A61K38/17 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K38/177 ,  C07K16/2896

    摘要： Certain cells, including types of cancer cells such as B-cell lymphomas, T cell lymphomas, Hodgkin's disease and myeloid leukemias, are capable of expressing Toll-like Receptor 9 (TLR9) or Toll-like Receptor 10 (TLR10) mRNA. Immunotargeting using TLR9 or TLR10 polypeptides, nucleic acids encoding for TLR9 or TLR10 polypeptides and anti-TLR9 or anti-TLR10 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the TLR9 or TLR10 protein. Methods of immunotherapy and diagnosis of disorders associated with TLR9 or TLR10 protein-expressing cells, such as B-cell lymphoma, T cell lymphoma, acute myeloid leukemia, Hodgkin's disease, B cell leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia and myelodysplastic syndromes, are described.

    摘要翻译： 某些细胞，包括癌细胞如B细胞淋巴瘤，T细胞淋巴瘤，霍奇金病和骨髓性白血病的类型能够表达Toll样受体9（TLR9）或Toll样受体10（TLR10）mRNA。 使用TLR9或TLR10多肽的免疫靶向，编码TLR9或TLR10多肽的核酸和抗TLR9或抗TLR10抗体提供了杀死或抑制表达TLR9或TLR10蛋白的癌细胞生长的方法。 B细胞淋巴瘤，T细胞淋巴瘤，急性骨髓性白血病，霍奇金病，B细胞白血病，慢性淋巴细胞性白血病，慢性骨髓性白血病和骨髓增生异常综合征的TLR9或TLR10蛋白表达细胞相关疾病的免疫治疗和诊断方法， 被描述。

    Methods of therapy and diagnosis using targeting of cells that express BCLP polypeptides
    10.
    发明申请
    Methods of therapy and diagnosis using targeting of cells that express BCLP polypeptides 审中-公开
    使用靶向表达BCLP多肽的细胞进行治疗和诊断的方法

    公开(公告)号：US20050158324A1

    公开(公告)日：2005-07-21

    申请号：US11014487

    申请日：2004-12-15

    申请人： Peter Emtage

    发明人： Peter Emtage

    IPC分类号： A61K38/17 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

    CPC分类号： G01N33/57419 ,  A61K38/1709 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2333/4731

    摘要： Certain cells, including cancer cells such as cells from cancers of the colon, breast, lung, ovary, prostate, pancreas and skin are capable of expressing BCLP. Targeting using BCLP polypeptides, nucleic acids encoding for BCLP polypeptides, anti-BCLP antibodies, peptides and small molecules provides a method of killing or inhibiting the growth of the cancer cells that express the BCLP protein. Methods for the diagnosis and therapy of tumors that express BCLP are described.

    摘要翻译： 某些细胞，包括癌细胞，如结肠癌，乳腺癌，肺癌，卵巢癌，前列腺癌，胰腺癌和皮肤癌的细胞都能够表达BCLP。 使用BCLP多肽的靶向，编码BCLP多肽的核酸，抗BCLP抗体，肽和小分子提供了杀死或抑制表达BCLP蛋白的癌细胞生长的方法。 描述了用于诊断和治疗表达BCLP的肿瘤的方法。