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公开(公告)号：US12064650B2
公开(公告)日：2024-08-20
申请号：US17374524
申请日：2021-07-13
申请人： EKOS CORPORATION
发明人： Azita Soltani , Adrian F. Prokop
CPC分类号： A61N7/022 , A61B17/2202 , A61M25/0032 , A61M37/0092 , A61B2017/22088 , A61B2017/22089 , A61M25/003 , Y10T29/49826
摘要： In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.
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公开(公告)号：US11058901B2
公开(公告)日：2021-07-13
申请号：US16268075
申请日：2019-02-05
申请人： EKOS CORPORATION
发明人： Azita Soltani , Adrian F. Prokop
摘要： In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.
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公开(公告)号：US20190223895A1
公开(公告)日：2019-07-25
申请号：US16239178
申请日：2019-01-03
申请人： EKOS CORPORATION
发明人： Kim R. Volz
IPC分类号： A61B17/22
摘要： In one embodiment of the present invention, an ultrasound catheter system comprising a catheter having at least one ultrasonic element; and a control system configured to generate power parameters to drive the ultrasonic element to generate ultrasonic energy is provided. The control system is configured to provide an ultrasonic pulse with a high pressure gradient with respect to time and/or distance. In another embodiment, a method of enhancing delivery of a therapeutic compound comprising delivering the therapeutic compound to a treatment site in a patient; and exposing the treatment site to an ultrasonic energy generated by an oscillating electrical signal pattern having a rise or fall rate greater than an sinusoidal pattern for the same amplitude and frequency is provided.
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公开(公告)号：US09943675B1
公开(公告)日：2018-04-17
申请号：US14477673
申请日：2014-09-04
申请人： EKOS CORPORATION
CPC分类号： A61M37/0092 , A61B17/320068
摘要： A method of treating an occlusion at a treatment site within a patient's vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.
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公开(公告)号：US20170182302A1
公开(公告)日：2017-06-29
申请号：US15414434
申请日：2017-01-24
申请人： EKOS CORPORATION
CPC分类号： A61M37/0092 , A61B2017/22088 , A61M5/142 , A61M25/0021 , A61M25/0026 , A61M25/0043 , A61M25/007 , A61M25/0071 , A61M27/00 , A61M27/006 , A61M2025/0002 , A61M2025/0078 , A61M2205/3334 , A61M2205/50 , A61M2210/0693
摘要： An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.
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公开(公告)号：US09579494B2
公开(公告)日：2017-02-28
申请号：US14209804
申请日：2014-03-13
申请人： EKOS CORPORATION
CPC分类号： A61M37/0092 , A61B2017/22088 , A61M5/142 , A61M25/0021 , A61M25/0026 , A61M25/0043 , A61M25/007 , A61M25/0071 , A61M27/00 , A61M27/006 , A61M2025/0002 , A61M2025/0078 , A61M2205/3334 , A61M2205/50 , A61M2210/0693
摘要： An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.
摘要翻译： 具有用于流体输送和排液的腔的超声导管和超声源用于治疗脑内或脑室内出血。 在将导管插入血块之后，可以通过管腔将裂解药物输送到血块，同时向治疗部位施加超声波能量。 当血块溶解时，液化血块可以通过内腔抽真空来除去。
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公开(公告)号：US20230263545A1
公开(公告)日：2023-08-24
申请号：US18141165
申请日：2023-04-28
申请人： EKOS CORPORATION
发明人： ROBERT L. WILCOX , RONALD L. HAAS
CPC分类号： A61B17/2202 , A61M25/003 , A61M25/00 , A61B18/24
摘要： An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.
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公开(公告)号：US20210339055A1
公开(公告)日：2021-11-04
申请号：US17374524
申请日：2021-07-13
申请人： EKOS CORPORATION
发明人： Azita Soltani , Adrian F. Prokop
摘要： In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.
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公开(公告)号：US20160361528A1
公开(公告)日：2016-12-15
申请号：US15178398
申请日：2016-06-09
申请人： EKOS CORPORATION
发明人： William Russell Kanz , Brent Twain Nistal , Eric Charles Whittaker , Raymond M. Wolniewicz, III , Randall James Beyreis , Michael Kuehn , Laura Elyn Ortega , Garrett Prahl , Travis Richard White
CPC分类号： G01K7/02 , A61B17/2202 , A61B2018/00797 , A61B2018/00821 , A61M2205/3368 , A61N7/022 , A61N2007/0078
摘要： A first tubular body having a first longitudinal axis extending centrally through the tubular body includes at least one delivery port extending through a wall of the first tubular body. A second tubular body having a second longitudinal axis extends through the second tubular body, the first and second longitudinal axes being displaced from each other such that an asymmetrical longitudinally extending gap is formed between an outer surface of the second tubular body and an interior surface of the first tubular body. A temperature sensor forming a thermocouple extending longitudinally within the gap between the first tubular body and the second tubular body. An inner core is positioned within the second tubular body. The inner core includes least one ultrasound element.
摘要翻译： 具有沿中心延伸穿过管状主体的第一纵向轴线的第一管状体包括延伸穿过第一管状体的壁的至少一个输送口。 具有第二纵向轴线的第二管状体延伸穿过第二管状体，第一和第二纵向轴线彼此移位，使得在第二管状体的外表面和第二管状体的内表面之间形成不对称的纵向延伸间隙 第一管状体。 形成热电偶的温度传感器，其在第一管状体和第二管状体之间的间隙内纵向延伸。 内芯位于第二管状体内。 内芯包括至少一个超声元件。
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