Clinical predictors of weight loss

    公开(公告)号:US11236392B2

    公开(公告)日:2022-02-01

    申请号:US15799271

    申请日:2017-10-31

    Abstract: Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent. One aspect discloses methods and compositions for obtaining a sample including deoxyribonucleic acids (DNA) from the subject, evaluating the DNA for an absence or presence of one or more genetic indicators and performing a first metabolic procedure or an alternative second metabolic procedure based on the absence or presence of the genetic indicator(s). Other aspects are also disclosed.

    Electrical ablation devices
    6.
    发明授权

    公开(公告)号:US10779882B2

    公开(公告)日:2020-09-22

    申请号:US15250507

    申请日:2016-08-29

    Abstract: An electrical ablation apparatus including first, second, and third electrodes is disclosed. Each of the first and second electrode is configured to be selectively extended outside and selectively retracted inside a distal end of its respective lumen and is configured to diverge from its respective longitudinal axis when extended outside the distal end of its respective lumen. The third electrode is non-rotatable and is configured to be selectively extended outside and selectively retracted inside a distal end of its respective lumen. The first, second and third electrodes are extendable into a tissue treatment region to create a first necrotic zone having a first shape. At least one of the first electrode or the second electrode is selectively rotatable within its respective lumen to create a second necrotic zone having a second shape. The third electrode is configured to positionally secure the electrical ablation apparatus at the tissue treatment region.

    Surgical instrument
    8.
    发明授权

    公开(公告)号:US10524854B2

    公开(公告)日:2020-01-07

    申请号:US14947449

    申请日:2015-11-20

    Abstract: A surgical instrument can comprise a first jaw and second jaw, wherein the first jaw is movable relative to the second jaw to capture tissue having a tissue thickness. A tissue cutting force monitor is configured to determine the tissue thickness of the captured tissue and communicate the tissue thickness to a controller, wherein the controller is configured to adjust the speed of a tissue-cutting element during a cutting portion of a firing stroke based on the tissue thickness communicated from the tissue cutting force monitor. The controller is configured to reduce the speed of the tissue-cutting element when the tissue cutting force monitor communicates a thicker tissue thickness to the controller. The controller is configured to increase the speed of the tissue-cutting element when the tissue cutting force monitor communicates a thinner tissue thickness to the controller.

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