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公开(公告)号:US20100151513A1
公开(公告)日:2010-06-17
申请号:US12520018
申请日:2007-12-18
CPC分类号: G01N1/36
摘要: A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.
摘要翻译: 一种组织嵌入器,其包括用于输入构件的输送机构,所述输入构件适于容纳多个组织支撑件,每个组织支撑件与模具相关联,蜡浴和冷却站,其中所述输送机构将输入构件从 蜡浴到冷却站。
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公开(公告)号:US09374995B2
公开(公告)日:2016-06-28
申请号:US13700258
申请日:2011-05-27
CPC分类号: A01N1/0284 , A01N1/0263 , A01N1/0268 , A61B17/43 , A61B17/435 , A61D19/022 , A61D19/025 , A61D19/04
摘要: An apparatus for micromanipulation of biological material, includes a vessel (1) having a reservoir (2) wherein the vessel has a channel (3) formed in a portion of the reservoir, the channel including an intermediate restriction (4) dimensioned to resist passage of the biological material but allow passage of liquid treatment solutions.
摘要翻译: 一种用于显微操作生物材料的装置,包括具有储存器(2)的容器(1),其中所述容器具有形成在所述储存器的一部分中的通道(3),所述通道包括中间限制(4) 的生物材料,但允许液体处理溶液通过。
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公开(公告)号:US09234823B2
公开(公告)日:2016-01-12
申请号:US12066013
申请日:2006-09-06
摘要: A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed, leaving the tissue sample correctly oriented in embedding material, mounted to a support, ready for microtoming.
摘要翻译: 提供了一种组织处理装置,其包括支撑件和定位器,用于处理和嵌入组织样本。 支撑和覆盖物形成室,在其中组织样品在加工之前被取向。 在处理之后,将腔室内的组织样本嵌入并移除定位器,使组织样本正确地定向在嵌入材料中,安装到支架上,准备进行切片。
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公开(公告)号:US09079127B2
公开(公告)日:2015-07-14
申请号:US13140328
申请日:2010-06-04
CPC分类号: B01D21/283 , B01D43/00
摘要: An apparatus including an acoustic transducer configured to acoustically associate with at least a portion of a fluid cavity. The fluid cavity is configured as a resonator. The acoustic transducer is configured to create an acoustic wave in the at least a portion of the fluid cavity. The acoustic wave is selected to increase the concentration of at least one particulate in a location in the fluid cavity.
摘要翻译: 一种包括声学换能器的装置,其被配置为与流体腔的至少一部分声学关联。 流体腔被配置为谐振器。 声换能器被配置为在流体腔的至少一部分中产生声波。 选择声波以增加流体腔中的位置中的至少一种颗粒的浓度。
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公开(公告)号:US20120329667A1
公开(公告)日:2012-12-27
申请号:US13501799
申请日:2010-10-13
CPC分类号: C12N15/1003 , C12Q1/6806 , C12Q2525/204 , C12Q2521/331
摘要: This application relates to methods for enriching DNA from a first cell type from a sample comprising DNA from the first cell type and DNA from a second cell type, wherein the first cell type methylates DNA to a lesser extent than the second cell type. DNA is enriched by, selecting for fragments by size after digestion of the sample with a methylation-sensitive restriction enzyme. Cell types of interest include fetal cells and cancerous cells. The enriched DNA can be used for a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译: 本申请涉及从包含来自第一细胞类型的DNA的样品和来自第二细胞类型的DNA的样品中富集来自第一细胞类型的DNA的方法,其中第一细胞类型的甲基化DNA的程度小于第二细胞类型。 DNA富集,用甲基化敏感性限制酶消化样品后,选择大小的片段。 感兴趣的细胞类型包括胎儿细胞和癌细胞。 富集的DNA可用于各种程序,包括检测感兴趣的性状,例如疾病特征,或遗传易感性,性别分型和亲本测试。
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公开(公告)号:US20120149014A1
公开(公告)日:2012-06-14
申请号:US13265485
申请日:2010-04-20
CPC分类号: C12Q1/6879 , C12N15/1003 , C12Q1/6806 , C12Q2600/156 , G01N33/483 , G01N33/5076 , G01N2015/1006
摘要: The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译: 本发明涉及从样品中富集胎儿核的方法。 丰富的胎儿核可用于各种手术,包括检测感兴趣的性状,如疾病特征,遗传易感性,性别分型和亲子鉴定。
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公开(公告)号:US09733166B2
公开(公告)日:2017-08-15
申请号:US12520018
申请日:2007-12-18
IPC分类号: G01N1/36
CPC分类号: G01N1/36
摘要: A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.
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公开(公告)号:US09447467B2
公开(公告)日:2016-09-20
申请号:US13265485
申请日:2010-04-20
IPC分类号: G01N33/483 , C12Q1/68 , G01N33/50 , C12N15/10 , G01N15/10
CPC分类号: C12Q1/6879 , C12N15/1003 , C12Q1/6806 , C12Q2600/156 , G01N33/483 , G01N33/5076 , G01N2015/1006
摘要: The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译: 本发明涉及从样品中富集胎儿核的方法。 丰富的胎儿核可用于各种手术,包括检测感兴趣的性状,如疾病特征,遗传易感性,性别分型和亲子鉴定。
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公开(公告)号:US20120267288A1
公开(公告)日:2012-10-25
申请号:US13140328
申请日:2010-06-04
IPC分类号: B07B7/00
CPC分类号: B01D21/283 , B01D43/00
摘要: An apparatus including an acoustic transducer configured to acoustically associate with at least a portion of a fluid cavity. The fluid cavity is configured as a resonator. The acoustic transducer is configured to create an acoustic wave in the at least a portion of the fluid cavity. The acoustic wave is selected to increase the concentration of at least one particulate in a location in the fluid cavity.
摘要翻译: 一种包括声学换能器的装置,其被配置为与流体腔的至少一部分声学关联。 流体腔被配置为谐振器。 声换能器被配置为在流体腔的至少一部分中产生声波。 选择声波以增加流体腔中的位置中的至少一个颗粒的浓度。
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公开(公告)号:US20120122091A1
公开(公告)日:2012-05-17
申请号:US13146376
申请日:2010-01-25
申请人: Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
发明人: Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
CPC分类号: A61B10/0291 , A61B10/0096 , A61B10/0283 , A61B90/06 , A61B2010/0074 , A61B2010/0216 , A61B2090/036 , A61B2090/062 , A61B2090/0807 , A61F13/38
摘要: A sampling device adapted for transcervical sampling of biological materials from a pregnant patient comprising: an elongate insertion tube (4) having a first end (5) adapted for insertion through the external orifice (external os) of said patient's cervix and a second end (6) including a handle means (7) for manipulating said tube; a measuring means for determining the position of said first end of said tube within said cervix, wherein said first end (5) includes a sampling head (9, 14) adapted to collect biological material including cells, mucus and biological fluids, and wherein said measuring means is adapted to determine the extent of insertion and transcervical position of said first end to optimise the transcervical sampling site.
摘要翻译: 一种适于对来自怀孕患者的生物材料进行子宫颈取样的采样装置,包括:细长插入管(4),其具有适于插入穿过所述患者子宫颈的外部孔(外部口)的第一端(5)和第二端 6)包括用于操纵所述管的手柄装置(7) 用于确定所述管子在所述子宫颈内的所述第一端的位置的测量装置,其中所述第一端(5)包括适于收集包括细胞,粘液和生物流体的生物材料的采样头(9,14),并且其中所述 测量装置适于确定所述第一端的插入程度和子宫颈位置以优化子宫颈取样部位。
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