-
公开(公告)号：US20120329667A1
公开(公告)日：2012-12-27
申请号：US13501799
申请日：2010-10-13
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q2525/204 , C12Q2521/331
摘要： This application relates to methods for enriching DNA from a first cell type from a sample comprising DNA from the first cell type and DNA from a second cell type, wherein the first cell type methylates DNA to a lesser extent than the second cell type. DNA is enriched by, selecting for fragments by size after digestion of the sample with a methylation-sensitive restriction enzyme. Cell types of interest include fetal cells and cancerous cells. The enriched DNA can be used for a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本申请涉及从包含来自第一细胞类型的DNA的样品和来自第二细胞类型的DNA的样品中富集来自第一细胞类型的DNA的方法，其中第一细胞类型的甲基化DNA的程度小于第二细胞类型。 DNA富集，用甲基化敏感性限制酶消化样品后，选择大小的片段。 感兴趣的细胞类型包括胎儿细胞和癌细胞。 富集的DNA可用于各种程序，包括检测感兴趣的性状，例如疾病特征，或遗传易感性，性别分型和亲本测试。
-
公开(公告)号：US20120149014A1
公开(公告)日：2012-06-14
申请号：US13265485
申请日：2010-04-20
CPC分类号： C12Q1/6879 , C12N15/1003 , C12Q1/6806 , C12Q2600/156 , G01N33/483 , G01N33/5076 , G01N2015/1006
摘要： The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本发明涉及从样品中富集胎儿核的方法。 丰富的胎儿核可用于各种手术，包括检测感兴趣的性状，如疾病特征，遗传易感性，性别分型和亲子鉴定。
-
公开(公告)号：US09447467B2
公开(公告)日：2016-09-20
申请号：US13265485
申请日：2010-04-20
IPC分类号： G01N33/483 , C12Q1/68 , G01N33/50 , C12N15/10 , G01N15/10
CPC分类号： C12Q1/6879 , C12N15/1003 , C12Q1/6806 , C12Q2600/156 , G01N33/483 , G01N33/5076 , G01N2015/1006
摘要： The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本发明涉及从样品中富集胎儿核的方法。 丰富的胎儿核可用于各种手术，包括检测感兴趣的性状，如疾病特征，遗传易感性，性别分型和亲子鉴定。
-
公开(公告)号：US09078642B2
公开(公告)日：2015-07-14
申请号：US13146376
申请日：2010-01-25
申请人： Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
发明人： Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
CPC分类号： A61B10/0291 , A61B10/0096 , A61B10/0283 , A61B90/06 , A61B2010/0074 , A61B2010/0216 , A61B2090/036 , A61B2090/062 , A61B2090/0807 , A61F13/38
摘要： A sampling device adapted for transcervical sampling of biological materials from a pregnant patient comprising: an elongate insertion tube (4) having a first end (5) adapted for insertion through the external orifice (external os) of said patient's cervix and a second end (6) including a handle means (7) for manipulating said tube; a measuring means for determining the position of said first end of said tube within said cervix, wherein said first end (5) includes a sampling head (9, 14) adapted to collect biological material including cells, mucus and biological fluids, and wherein said measuring means is adapted to determine the extent of insertion and transcervical position of said first end to optimize the transcervical sampling site.
摘要翻译： 一种适于对来自怀孕患者的生物材料进行子宫颈取样的采样装置，包括：细长插入管（4），其具有适于插入穿过所述患者子宫颈的外部孔（外部口）的第一端（5）和第二端 6）包括用于操纵所述管的手柄装置（7） 用于确定所述管子在所述子宫颈内的所述第一端的位置的测量装置，其中所述第一端（5）包括适于收集包括细胞，粘液和生物流体的生物材料的采样头（9,14），并且其中所述 测量装置适于确定所述第一端的插入程度和子宫颈位置以优化子宫颈取样部位。
-
公开(公告)号：US20120122091A1
公开(公告)日：2012-05-17
申请号：US13146376
申请日：2010-01-25
申请人： Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
发明人： Eduardo Vom , Craig Lewis , Richard Allman , Debbie Mantzaris
CPC分类号： A61B10/0291 , A61B10/0096 , A61B10/0283 , A61B90/06 , A61B2010/0074 , A61B2010/0216 , A61B2090/036 , A61B2090/062 , A61B2090/0807 , A61F13/38
摘要： A sampling device adapted for transcervical sampling of biological materials from a pregnant patient comprising: an elongate insertion tube (4) having a first end (5) adapted for insertion through the external orifice (external os) of said patient's cervix and a second end (6) including a handle means (7) for manipulating said tube; a measuring means for determining the position of said first end of said tube within said cervix, wherein said first end (5) includes a sampling head (9, 14) adapted to collect biological material including cells, mucus and biological fluids, and wherein said measuring means is adapted to determine the extent of insertion and transcervical position of said first end to optimise the transcervical sampling site.
摘要翻译： 一种适于对来自怀孕患者的生物材料进行子宫颈取样的采样装置，包括：细长插入管（4），其具有适于插入穿过所述患者子宫颈的外部孔（外部口）的第一端（5）和第二端 6）包括用于操纵所述管的手柄装置（7） 用于确定所述管子在所述子宫颈内的所述第一端的位置的测量装置，其中所述第一端（5）包括适于收集包括细胞，粘液和生物流体的生物材料的采样头（9,14），并且其中所述 测量装置适于确定所述第一端的插入程度和子宫颈位置以优化子宫颈取样部位。
-
公开(公告)号：US20120315633A1
公开(公告)日：2012-12-13
申请号：US13518454
申请日：2010-12-22
CPC分类号： C12Q1/6806 , C12Q1/6883 , C12Q1/6888 , C12Q2600/156 , C12Q2523/32
摘要： The present invention relates to a method of enriching free fetal nucleic acids from a cervical sample. The enriched fetal nucleic acids can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本发明涉及从宫颈样品中富集游离胎儿核酸的方法。 富集的胎儿核酸可以以多种方法使用，包括检测感兴趣的性状，例如疾病特征，或遗传易感性，性别分型和亲本测试。
-
公开(公告)号：US20110027795A1
公开(公告)日：2011-02-03
申请号：US12918015
申请日：2009-02-18
申请人： Debbie Mantzaris , Richard Allman
发明人： Debbie Mantzaris , Richard Allman
CPC分类号： C12N5/0603
摘要： The present invention relates to methods of processing and/or enriching cells from a pregnant female. More particularly the invention provides methods for processing and/or enriching fetal cells from a pregnant female. The enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本发明涉及从孕妇处理和/或富集细胞的方法。 更具体地，本发明提供了从孕妇处理和/或富集胎儿细胞的方法。 富集的胎儿细胞可以以各种方法使用，包括检测感兴趣的性状，例如疾病特征，或遗传易感性，性别分型和亲本测试。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.046 秒)
