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    Methods of manufacturing reagent test strips
    1.
    发明授权
    Methods of manufacturing reagent test strips 有权
    制造试剂条的方法

    公开(公告)号：US06800488B2

    公开(公告)日：2004-10-05

    申请号：US09737179

    申请日：2000-12-13

    申请人： Tahir Sadik Khan ,  Yeung Siu Yu ,  Edward G. Rice

    发明人： Tahir Sadik Khan ,  Yeung Siu Yu ,  Edward G. Rice

    IPC分类号： G01N2175

    CPC分类号： G01N33/54366 ,  Y10T436/144444

    摘要： Methods for making reagent test strips are provided. In the subject methods, a test strip precursor made up of an elongated support material having a planar surface and a narrow stripe of reagent material positioned along its central axis is cut according to an inter-digitating pattern to produce the plurality of reagent test strips. The initial precursor material may be a tape or in the form of a card. Also provided are the reagent test strips produced by the subject methods and kits that include the same. The subject reagent test strips and kits find use in analyte detection and/or concentration determination assays.

    摘要翻译： 提供制备试剂条的方法。 在本发明的方法中，根据数字间图案切割由具有平坦表面的细长支撑材料和沿其中心轴定位的窄条试剂材料的测试条前体，以产生多个试剂测试条。 初始前体材料可以是带或卡的形式。 还提供了由主题方法和试剂盒制备的试剂测试条，其包括相同的试剂。 主题试剂测试条和试剂盒可用于分析物检测和/或浓度测定测定。

    Visual blood glucose concentration test strip
    3.
    发明授权
    Visual blood glucose concentration test strip 失效
    视觉血糖浓度测试条

    公开(公告)号：US5306623A

    公开(公告)日：1994-04-26

    申请号：US736537

    申请日：1991-07-26

    申请人： Ernest J. Kiser ,  Edward G. Rice ,  Michael F. Tomasco

    发明人： Ernest J. Kiser ,  Edward G. Rice ,  Michael F. Tomasco

    IPC分类号： C12Q1/00 ,  C12Q1/54 ,  G01N33/48 ,  G01N33/52 ,  C12Q1/26 ,  C12Q1/28 ,  G01N21/00

    CPC分类号： G01N33/48 ,  C12Q1/54 ,  G01N33/521 ,  G01N33/523 ,  Y10T436/25375

    摘要： A separation matrix impregnated with a separating agent separates red blood cells or hemoglobin from whole blood. Upon separation, an impregnated test reagent reacts with the separated substantially clear component fluid to form a colored product which enables a visual or meter test for analyte levels in whole blood. Such a test is appropriate for, among other things measuring glucose, cholesterol, or alcohol levels in whole blood samples. A visual meter is disclosed which allows sample to be applied to one side of the strip, and reading takes place on the opposite side, after separation of red blood cells and reaction to test reagent. Also, a useful test strip format is disclosed.

    摘要翻译： 用分离剂浸渍的分离基质将红细胞或血红蛋白与全血分离。 在分离时，浸渍的测试试剂与分离的基本上透明的组分流体反应以形成有色产物，其能够对全血中的分析物水平进行视觉或仪表测试。 这样的测试适合于测量全血样品中的葡萄糖，胆固醇或酒精水平。 公开了一种能够将样品施加到条的一侧的视觉仪表，并且在分离红细胞并与测试试剂反应之后，在相对侧进行读取。 此外，公开了一种有用的测试条格式。

    Blood glucose strip having reduced side reactions
    4.
    发明授权
    Blood glucose strip having reduced side reactions 失效
    血葡萄糖条具有减少的副反应

    公开(公告)号：US5620863A

    公开(公告)日：1997-04-15

    申请号：US486930

    申请日：1995-06-07

    申请人： Michael F. Tomasco ,  Maria Teodorczyk ,  Remedios Dato ,  Edward G. Rice

    发明人： Michael F. Tomasco ,  Maria Teodorczyk ,  Remedios Dato ,  Edward G. Rice

    IPC分类号： C12Q1/54 ,  G01N33/543 ,  C12Q1/28 ,  G01N21/00

    CPC分类号： G01N33/54386 ,  C12Q1/54

    摘要： A reagent strip for measuring glucose concentration in a biological fluid containing red blood cells has reduced interference of hematocrit with the glucose measurement. When a biological fluid contacts the strip, it causes, in a reagent impregnated in the strip, a color change which is a measure of the glucose concentration in the fluid. However, the color change is also affected by the red blood cell concentration (hematocrit), thereby reducing the accuracy of the glucose measurement. The hematocrit effect is reduced by adding to the reagent a component, such as imidazole or imidazole and N-acetylglucosamine, for minimizing side reactions of the glucose, or its reaction products, with the fluid.

    摘要翻译： 用于测量含有红细胞的生物流体中的葡萄糖浓度的试剂条减少了血细胞比容与葡萄糖测量的干扰。 当生物流体接触条带时，其在浸渍在条带中的试剂中导致颜色变化，其是测量流体中的葡萄糖浓度。 然而，颜色变化也受红细胞浓度（血细胞比容）影响，从而降低葡萄糖测量的准确性。 通过向试剂中加入诸如咪唑或咪唑和N-乙酰葡糖胺的组分，以使葡萄糖或其反应产物与流体的副反应最小化来降低血细胞比容效应。

    Chemical timer for a visual test strip
    6.
    发明授权
    Chemical timer for a visual test strip 失效
    化学计时器用于视觉测试条

    公开(公告)号：US5719034A

    公开(公告)日：1998-02-17

    申请号：US706753

    申请日：1996-09-03

    申请人： Ernest J. Kiser ,  Michael F. Tomasco ,  Edward G. Rice ,  Yeung S. Yu

    发明人： Ernest J. Kiser ,  Michael F. Tomasco ,  Edward G. Rice ,  Yeung S. Yu

    IPC分类号： G01N31/22 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  G01N21/78 ,  G01N33/52 ,  G01N33/558 ,  G01N33/66 ,  C12Q1/28 ,  G01N21/00

    CPC分类号： G01N33/521 ,  C12Q1/54 ,  G01N33/523 ,  G01N33/526 ,  G01N33/558

    摘要： A chemical timer for a direct-reading reagent test strip changes color a predetermined time after a biological fluid is applied to the strip. The strip measures the concentration of an analyte in the fluid. The timer is a dry coating of an indicator, an enzyme-containing reagent that when hydrated can react with glucose to change the color of the indicator, an inhibitor to inhibit the change in color of the indicator, glucose, and optionally, an aldose that does not react with the enzyme in the reagent. Preferably, the reagent and glucose are present in excess in the coating, and the time it takes for the timer color to change can be controlled by the inhibitor concentration. The aldose provides timer stability, probably by interfering with glycosylation by the glucose in the dry state.

    摘要翻译： 用于直接读取试剂测试条的化学计时器在生物流体施加到条带之后的预定时间内改变颜色。 条带测量流体中分析物的浓度。 定时器是指示剂的干燥涂层，其是含酶试剂，其在水合时可与葡萄糖反应以改变指示剂的颜色，抑制剂抑制指示剂，葡萄糖和任选地醛糖的变色 不与试剂中的酶反应。 优选地，试剂和葡萄糖在涂层中过量存在，并且定时器颜色改变所需的时间可以通过抑制剂浓度来控制。 醛糖提供定时器稳定性，可能通过在干燥状态下干扰葡萄糖的糖基化。