公开(公告)号：US06949221B2

公开(公告)日：2005-09-27

申请号：US10113063

申请日：2002-03-28

申请人： Ernest J. Kiser ,  Deborah P. Tuohy ,  John M. Dubowik

发明人： Ernest J. Kiser ,  Deborah P. Tuohy ,  John M. Dubowik

IPC分类号： C12Q1/54 ,  G01N33/48 ,  G01N33/52 ,  G01N33/543 ,  G01N21/00

CPC分类号： C12Q1/54 ,  G01N33/48 ,  G01N33/521 ,  G01N33/523 ,  G01N33/54386 ,  Y10T156/10

摘要： A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, and uncompressed portions. The uncompressed portions are adapted to absorb and retain body fluids in excess of the amount required for operation of the test strip. The test strip may be constructed with an internal relief chamber to accommodate the uncompressed portions. A method of making the test strip by pressure and/or heat sealing individual components on a shaping die is also provided.

摘要翻译： 用于测定体液中分析物浓度的测试条包括与多孔层流体连通的膜。 膜和多孔层被分成压缩部分，其限制体液的毛细管流动和未压缩部分。 未压缩部分适于吸收和保持体液超过测试条的操作所需的量。 测试条可以构造有内部释放室以容纳未压缩部分。 还提供了通过压制和/或热封成型模具上的各个部件来制造测试条的方法。

公开(公告)号：US06395227B1

公开(公告)日：2002-05-28

申请号：US08442035

申请日：1995-05-16

申请人： Ernest J. Kiser ,  Deborah P. Tuohy ,  John M. Dubowik

发明人： Ernest J. Kiser ,  Deborah P. Tuohy ,  John M. Dubowik

IPC分类号： G01N2100

CPC分类号： C12Q1/54 ,  G01N33/48 ,  G01N33/521 ,  G01N33/523 ,  G01N33/54386 ,  Y10T156/10

摘要： A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, and uncompressed portions. The uncompressed portions are adapted to absorb and retain body fluids in excess of the amount required for operation of the test strip. The test strip may be constructed with an internal relief chamber to accommodate the uncompressed portions. A method of making the test strip by pressure and/or heat sealing individual components on a shaping die is also provided.

公开(公告)号：US5843691A

公开(公告)日：1998-12-01

申请号：US779735

申请日：1996-12-31

申请人： Joel Douglas ,  Ernest Kiser ,  Michael F. Tomasco ,  Remedios Dato ,  Edward G. Rice ,  Deborah P. Tuohy ,  Mark Maxson ,  Zbigniew Witko ,  Scott Segelke

发明人： Joel Douglas ,  Ernest Kiser ,  Michael F. Tomasco ,  Remedios Dato ,  Edward G. Rice ,  Deborah P. Tuohy ,  Mark Maxson ,  Zbigniew Witko ,  Scott Segelke

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/558 ,  G01N33/66 ,  C12Q1/28 ,  G01N21/00

CPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N33/521 ,  G01N33/523 ,  G01N33/526 ,  G01N33/558

摘要： A multilayer reagent test strip measures the concentration of analyte in a liquid sample that is applied to it. The sample is guided to a number of assay areas arrayed along the strip, where the analyte can react with a reagent to cause a color change. Each assay area also includes an inhibitor for the color-change reaction. The inhibitor concentration increases in successive assay areas; thus, the number of areas that change color is a measure of the analyte concentration. The test strip is particularly adapted for measuring glucose in a whole blood sample. In a preferred embodiment, the sample is guided to the assay areas along a path formed by crushing selected areas of a membrane, and the assay areas are uncrushed areas of the membrane.

摘要翻译： 多层试剂测试条测量施加于其上的液体样品中分析物的浓度。 将样品引导到沿着条带排列的多个测定区域，其中分析物可以与试剂反应以引起颜色变化。 每个测定区域还包括用于变色反应的抑制剂。 连续测定区域的抑制剂浓度增加; 因此，改变颜色的区域的数量是分析物浓度的量度。 测试条特别适用于测量全血样品中的葡萄糖。 在优选的实施方案中，将样品引导到沿着通过破碎膜的选定区域形成的路径的测定区域，并且测定区域是膜的未破碎区域。

公开(公告)号：US06986869B2

公开(公告)日：2006-01-17

申请号：US10113066

申请日：2002-03-28

申请人： Deborah P. Tuohy ,  John M. Dubowik

发明人： Deborah P. Tuohy ,  John M. Dubowik

IPC分类号： G01N21/00

CPC分类号： C12Q1/54 ,  G01N33/48 ,  G01N33/521 ,  G01N33/523 ,  G01N33/54386 ,  Y10T156/10

摘要： A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, and uncompressed portions. The uncompressed portions are adapted to absorb and retain body fluids in excess of the amount required for operation of the test strip. The test strip may be constructed with an internal relief chamber to accommodate the uncompressed portions. A method of making the test strip by pressure and/or heat sealing individual components on a shaping die is also provided.