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公开(公告)号：US10188733B2
公开(公告)日：2019-01-29
申请号：US13880795
申请日：2011-10-21
IPC分类号： A61K39/395 , A61K47/24 , A61K39/00 , A61K47/02
摘要： The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate B cell antibody secretion. Accordingly, the present invention provides vaccines comprising a bisphosphonate, methods for stimulating an immune response, enhancing the immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same.
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公开(公告)号：US08637028B2
公开(公告)日：2014-01-28
申请号：US13123888
申请日：2009-10-09
申请人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
IPC分类号： A61K39/40 , A61K39/395 , A61K49/04
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中，免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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3.发明申请ADJUVANT INCORPORATION IN IMMUNONANOTHERAPEUTICS 有权ADJUVANT INCORPORATION IN IMMUNANANOTHERAPEUTICS公开(公告)号：US20110268805A1
公开(公告)日：2011-11-03
申请号：US13123888
申请日：2009-10-09
申请人： Frank Alexis , Matteo Iannacone , Jinjin Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjin Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
IPC分类号： A61K9/14 , A61K39/39 , A61K38/21 , A61P37/04 , A61K38/20 , A61K39/02 , A61K39/12 , A61K39/00 , A61K39/002
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中，免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号：US10736848B2
公开(公告)日：2020-08-11
申请号：US12681814
申请日：2008-10-12
申请人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
发明人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US20130129790A1
公开(公告)日：2013-05-23
申请号：US13651124
申请日：2012-10-12
申请人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich Von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich Von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中，免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号：US08343498B2
公开(公告)日：2013-01-01
申请号：US12428395
申请日：2009-04-22
申请人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中，免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号：US20110268804A1
公开(公告)日：2011-11-03
申请号：US13123884
申请日：2009-10-09
申请人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
发明人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
IPC分类号： A61K9/14 , A61P37/02 , A61P37/04 , A61K47/48 , A61K39/385
CPC分类号： A61K47/48869 , A61K39/00 , A61K47/6925 , A61K47/6935
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫电泳表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含纳米载体的药物组合物。 本发明提供了纳米载体及其药物组合物的设计，制造和使用方法。
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公开(公告)号：US08932595B2
公开(公告)日：2015-01-13
申请号：US13123886
申请日：2009-10-09
申请人： Matteo Iannacone , Ulrich von Andrian , Omid C. Farokhzad , Frank Alexis , Pamela Basto , Jinjun Shi , Elliott Ashley Moseman , Robert S. Langer , Elena Tonti
发明人： Matteo Iannacone , Ulrich von Andrian , Omid C. Farokhzad , Frank Alexis , Pamela Basto , Jinjun Shi , Elliott Ashley Moseman , Robert S. Langer , Elena Tonti
CPC分类号： A61K39/00
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。 本发明提供包含纳米载体的药物组合物。 本发明提供了纳米载体及其药物组合物的设计，制造和使用方法。 例如，本发明描述能够引发免疫应答和产生抗尼古丁抗体的纳米载体。
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公开(公告)号：US08591905B2
公开(公告)日：2013-11-26
申请号：US12428388
申请日：2009-04-22
申请人： Ulrich von Andrian , Omid C. Farokhzad , Frank Alexis , Matteo Iannacone , Pamela Basto , Jinjun Shi , Elliott Ashley Moseman , Robert S. Langer , Elena Tonti
发明人： Ulrich von Andrian , Omid C. Farokhzad , Frank Alexis , Matteo Iannacone , Pamela Basto , Jinjun Shi , Elliott Ashley Moseman , Robert S. Langer , Elena Tonti
CPC分类号： A61K39/00
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。 例如，本发明能够引发免疫应答的纳米载体和抗尼古丁抗体的产生。
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公开(公告)号：US08562998B2
公开(公告)日：2013-10-22
申请号：US13123884
申请日：2009-10-09
申请人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
发明人： Jinjun Shi , Frank Alexis , Matteo Iannacone , Elliott Ashley Moseman , Pamela Basto , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
CPC分类号： A61K47/48869 , A61K39/00 , A61K47/6925 , A61K47/6935
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫电泳表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含纳米载体的药物组合物。 本发明提供了纳米载体及其药物组合物的设计，制造和使用方法。
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