Vaccine Nanotechnology
    2.
    发明申请
    Vaccine Nanotechnology 审中-公开
    疫苗纳米技术

    公开(公告)号:US20100233251A1

    公开(公告)日:2010-09-16

    申请号:US12681814

    申请日:2008-10-12

    IPC分类号: A61K9/127 A61K9/14 A61K39/00

    摘要: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

    摘要翻译: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体,在一些实施方案中,包含至少一种免疫调节剂,并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计,制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病,病症和病症的方法,包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。

    Nicotine immunonanotherapeutics
    9.
    发明授权
    Nicotine immunonanotherapeutics 有权
    尼古丁免疫治疗

    公开(公告)号:US08591905B2

    公开(公告)日:2013-11-26

    申请号:US12428388

    申请日:2009-04-22

    IPC分类号: A61K39/00 A61K47/00

    CPC分类号: A61K39/00

    摘要: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

    摘要翻译: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计,制造和使用本发明的纳米载体及其药物组合物的方法。 例如,本发明能够引发免疫应答的纳米载体和抗尼古丁抗体的产生。