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    PH sensitive biodegradable polymeric particles for drug delivery
    8.
    发明授权
    PH sensitive biodegradable polymeric particles for drug delivery 有权
    PH敏感的生物可降解聚合物颗粒用于药物递送

    公开(公告)号：US09532956B2

    公开(公告)日：2017-01-03

    申请号：US12762348

    申请日：2010-04-18

    申请人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

    发明人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

    IPC分类号： A61K47/30 ,  G01N21/76 ,  A61K9/51 ,  A61K48/00 ,  C12N15/11 ,  C12N15/115

    CPC分类号： A61K9/51 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/32

    摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.

    摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。

    System for screening particles
    9.
    发明授权
    System for screening particles 有权
    颗粒筛选系统

    公开(公告)号：US09267937B2

    公开(公告)日：2016-02-23

    申请号：US12097118

    申请日：2006-12-15

    申请人： Omid C. Farokhzad ,  Aleksandar Filip Radovic-Moreno ,  Robert S. Langer

    发明人： Omid C. Farokhzad ,  Aleksandar Filip Radovic-Moreno ,  Robert S. Langer

    IPC分类号： C40B30/06 ,  G01N33/50 ,  B82Y5/00 ,  B82Y15/00 ,  A61K47/48

    CPC分类号： G01N33/5088 ,  A61K47/555 ,  A61K47/66 ,  A61K47/6891 ,  B82Y5/00 ,  B82Y15/00 ,  C40B30/06

    摘要： Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.

    摘要翻译： 使用Polyplex迭代组合优化（PICO）在体内和/或体外筛选粒子库允许设计用于靶向特定器官，组织（例如癌症）或细胞的颗粒。 例如，颗粒可以在其表面上包括不同的靶向剂（例如，适体或多个适配体），并且适配体或适体可以进化以提供更好的颗粒靶向。 已经发现已经发现迁移到感兴趣的组织，被细胞吸收的颗粒的特征的颗粒的富集等。可以重复该过程来设计具有所需特异性或生物学功能的颗粒。