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![Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators](/abs-image/US/2013/08/27/US08519000B2/abs.jpg.150x150.jpg)
1.发明授权Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators 有权取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物及其作为钠和/或钙通道调节剂的用途公开(公告)号：US08519000B2
公开(公告)日：2013-08-27
申请号：US12663926
申请日：2008-05-14
申请人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
发明人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
IPC分类号： A61K31/165 , C07C237/08 , C07C233/05 , C07C233/65
CPC分类号： A61K31/381 , A61K31/137 , A61K31/165 , A61K31/40 , A61K31/4515 , A61K31/519 , A61K31/5513 , C07C237/06 , C07C237/08 , C07C237/20 , C07C317/28 , C07C321/26 , C07C323/25 , C07C327/42 , C07C327/44 , C07D207/16 , C07D295/182 , C07D333/20
摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly used for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital, and gastrointestinal diseases.
摘要翻译： 取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。 这些化合物可以特别用于预防，缓解和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。
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2.发明授权公开(公告)号：US08445539B2
公开(公告)日：2013-05-21
申请号：US12816143
申请日：2010-06-15
IPC分类号： A61K31/165
CPC分类号： A61K31/165
摘要： The disclosure relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety, wherein schizophrenia includes schizophrenia related disorders such as brief psychotic disorders, delusional disorders, schizoaffective disorders, and schizophreniform disorders, and anxiety includes panic disorders, obsessive-compulsive disorders (OCD), post-traumatic stress disorders (PTSD), social phobia or social anxiety disorders, specific phobia, and generalized anxiety disorders (GAD). The compounds of the disclosure are useful for the treatment of the above psychiatric disorders alone or in combination with other therapeutical agents effective in the treatment of schizophrenia and/or anxiety disorders.
摘要翻译： 本公开涉及精神障碍和/或焦虑症的精神障碍的药物治疗，其中精神分裂症包括精神分裂症相关的疾病，例如短暂性精神病，妄想障碍，分裂情感障碍和精神分裂症样症状，焦虑包括恐慌症，强迫症（强迫症） OCD），创伤后应激障碍（PTSD），社交恐惧症或社会焦虑症，特定恐惧症和广泛性焦虑症（GAD）。 本公开的化合物可用于单独或与治疗精神分裂症和/或焦虑症有效的其它治疗剂组合治疗上述精神障碍。
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3.发明申请ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS 有权用于治疗心理疾病的ALPHA-氨基腺苷衍生物公开(公告)号：US20110014304A1
公开(公告)日：2011-01-20
申请号：US12816143
申请日：2010-06-15
IPC分类号： A61K31/165 , A61K31/551 , A61K31/496 , A61K31/4515 , A61K31/519 , A61K33/00 , A61K31/53 , A61P25/00 , A61P25/18 , A61P25/22
CPC分类号： A61K31/165
摘要： The disclosure relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety, wherein schizophrenia includes schizophrenia related disorders such as brief psychotic disorders, delusional disorders, schizoaffective disorders, and schizophreniform disorders, and anxiety includes panic disorders, obsessive-compulsive disorders (OCD), post-traumatic stress disorders (PTSD), social phobia or social anxiety disorders, specific phobia, and generalized anxiety disorders (GAD). The compounds of the disclosure are useful for the treatment of the above psychiatric disorders alone or in combination with other therapeutical agents effective in the treatment of schizophrenia and/or anxiety disorders.
摘要翻译： 本公开涉及精神障碍和/或焦虑症的精神障碍的药物治疗，其中精神分裂症包括精神分裂症相关的疾病，例如短暂性精神病，妄想障碍，分裂情感障碍和精神分裂症样症状，焦虑包括恐慌症，强迫症（强迫症） OCD），创伤后应激障碍（PTSD），社交恐惧症或社会焦虑症，特定恐惧症和广泛性焦虑症（GAD）。 本公开的化合物可用于单独或与治疗精神分裂症和/或焦虑症有效的其它治疗剂组合治疗上述精神障碍。
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4.发明申请Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of l-dopa induced movement disorders, dyskinesias, drug addiction, pain and cataract 审中-公开使用犬尿氨酸-3-羟化酶抑制剂制备用于治疗多巴诱导的运动障碍，运动障碍，药物成瘾，疼痛和白内障的药物公开(公告)号：US20070112025A1
公开(公告)日：2007-05-17
申请号：US10555233
申请日：2004-05-04
申请人： Patricia Salvati , Emanuela Izzo
发明人： Patricia Salvati , Emanuela Izzo
IPC分类号： A61K31/4704
CPC分类号： A61K31/192 , A61K31/426
摘要： Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of L-DOPA induced movement disorders, dyskinesias, drug addiction, pain and cataract.
摘要翻译： 使用犬尿氨酸-3-羟化酶抑制剂制备用于治疗L-DOPA诱发的运动障碍，运动障碍，药物成瘾，疼痛和白内障的药物。
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5.发明授权公开(公告)号：US08445513B2
公开(公告)日：2013-05-21
申请号：US11578988
申请日：2005-04-19
申请人： Claudia Besana , Elena Barbanti , Emanuela Izzo , Florian Thaler , Ruggero Fariello , Patricia Salvati , Luca Benatti
发明人： Claudia Besana , Elena Barbanti , Emanuela Izzo , Florian Thaler , Ruggero Fariello , Patricia Salvati , Luca Benatti
IPC分类号： A61K31/445 , A61K31/40 , A61K31/277 , A61K31/165 , A61K31/137
CPC分类号： A61K31/165 , A61K31/198 , A61K31/381 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of certain alpha-aminoamide derivatives in the treatment of RLS and addictive disorders. The compounds of this invention are able to reduce or even stop the symptoms of RLS and addictive disorders substantially without side effects.
摘要翻译： 本发明涉及某些α-氨基酰胺衍生物在治疗RLS和成瘾性疾病中的应用。 本发明的化合物能够基本上没有副作用减少甚至停止RLS和成瘾性疾病的症状。
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![SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS](/abs-image/US/2010/08/19/US20100210631A1/abs.jpg.150x150.jpg)
6.发明申请SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS 有权取代的2- [2-（苯基）乙酰胺]烷基胺衍生物及其作为钠和/或钙通道调节剂的用途公开(公告)号：US20100210631A1
公开(公告)日：2010-08-19
申请号：US12663926
申请日：2008-05-14
申请人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
发明人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
IPC分类号： A61K31/551 , C07C237/20 , A61K31/165 , C07C321/26 , A61P25/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P25/18 , A61P25/22 , A61P25/30 , A61P25/24 , A61K31/445 , A61K31/519 , A61P29/00
CPC分类号： A61K31/381 , A61K31/137 , A61K31/165 , A61K31/40 , A61K31/4515 , A61K31/519 , A61K31/5513 , C07C237/06 , C07C237/08 , C07C237/20 , C07C317/28 , C07C321/26 , C07C323/25 , C07C327/42 , C07C327/44 , C07D207/16 , C07D295/182 , C07D333/20
摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly used for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital, and gastrointestinal diseases.
摘要翻译： 取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。 这些化合物可以特别用于预防，缓解和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。
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7.发明申请Alpha-Aminoamide Derivatives Useful In The Treatment Of Restless Legs Syndrome And Addictive Disorders 有权用于治疗不宁腿综合征和上瘾性疾病的α-氨基酰胺衍生物公开(公告)号：US20070203182A1
公开(公告)日：2007-08-30
申请号：US11578988
申请日：2005-04-19
申请人： Claudia Besana , Elena Barbanti , Emanuela Izzo , Florian Thaler , Ruggero Fariello , Patricia Salvati , Luca Benatti
发明人： Claudia Besana , Elena Barbanti , Emanuela Izzo , Florian Thaler , Ruggero Fariello , Patricia Salvati , Luca Benatti
IPC分类号： A61K31/445 , A61K31/40 , A61K31/277 , A61K31/165 , A61K31/137
CPC分类号： A61K31/165 , A61K31/198 , A61K31/381 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of certain alpha-aminoamide derivatives in the treatment of RLS and addictive disorders. The compounds of this invention are able to reduce or even stop the symptoms of RLS and addictive disorders substantially without side effects.
摘要翻译： 本发明涉及某些α-氨基酰胺衍生物在治疗RLS和成瘾性疾病中的应用。 本发明的化合物能够基本上没有副作用减少甚至停止RLS和成瘾性疾病的症状。
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