公开(公告)号：US20090274667A1

公开(公告)日：2009-11-05

申请号：US12428456

申请日：2009-04-22

申请人： Sally Temple ,  Jeffrey Stern ,  Enrique L. Salero-Coca

发明人： Sally Temple ,  Jeffrey Stern ,  Enrique L. Salero-Coca

IPC分类号： A61K35/12 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： A61K38/1825 ,  C12N5/0607 ,  C12N5/0619 ,  C12N5/0621 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2533/52

摘要： The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.

摘要翻译： 本发明涉及从成年哺乳动物的视网膜色素上皮的后部区域分离的视网膜色素上皮干细胞。 本发明还涉及在体外诱导视网膜上皮干细胞和祖细胞分化的方法，其中本发明的细胞是高度塑性的，多能干细胞。 本发明还包括治疗视网膜疾病和视力丧失的方法，涉及将视网膜色素上皮干细胞或从视网膜色素上皮干细胞分化的细胞移植到需要治疗的患者的视网膜中。

公开(公告)号：US08481313B2

公开(公告)日：2013-07-09

申请号：US12428456

申请日：2009-04-22

申请人： Sally Temple ,  Jeffrey Stern ,  Enrique L. Salero-Coca

发明人： Sally Temple ,  Jeffrey Stern ,  Enrique L. Salero-Coca

IPC分类号： C12N5/00 ,  C12N5/079 ,  C12N5/0797 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  A01N1/00

CPC分类号： A61K38/1825 ,  C12N5/0607 ,  C12N5/0619 ,  C12N5/0621 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2533/52

摘要： The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.

摘要翻译： 本发明涉及从成年哺乳动物的视网膜色素上皮的后部区域分离的视网膜色素上皮干细胞。 本发明还涉及在体外诱导视网膜上皮干细胞和祖细胞分化的方法，其中本发明的细胞是高度塑性的，多能干细胞。 本发明还包括治疗视网膜疾病和视力丧失的方法，涉及将视网膜色素上皮干细胞或从视网膜色素上皮干细胞分化的细胞移植到需要治疗的患者的视网膜中。