Substituted Heteroaryl- and Phenylsulfamoyl Compounds
    6.
    发明申请
    Substituted Heteroaryl- and Phenylsulfamoyl Compounds 审中-公开
    取代的杂芳基 - 和苯基氨磺酰基化合物

    公开(公告)号:US20060258723A1

    公开(公告)日:2006-11-16

    申请号:US11424626

    申请日:2006-06-16

    摘要: The present invention is directed at substituted heteroaryl and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator actuator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.

    摘要翻译: 本发明涉及取代的杂芳基和苯基氨磺酰基化合物,含有这些化合物的药物组合物以及这些化合物如过氧化物酶体增殖物激动剂受体(PPAR)激动剂的用途。 PPARα激活剂,含有这些化合物的药物组合物以及使用这些化合物来提高某些血浆脂质水平,包括高密度脂蛋白胆固醇和降低某些其他血浆脂质水平,如低密度脂蛋白胆固醇和甘油三酸酯,从而治疗 由哺乳动物(包括人类)中低密度脂蛋白胆固醇和/或高水平的低密度脂蛋白胆固醇和甘油三酯(如动脉粥样硬化和心血管疾病)而加剧。 该化合物也可用于治疗反能动物中的负能量平衡(NEB)和相关疾病。

    Substituted Heteroaryl- and Phenylsulfamoyl Compounds
    7.
    发明申请
    Substituted Heteroaryl- and Phenylsulfamoyl Compounds 审中-公开
    取代的杂芳基 - 和苯基氨磺酰基化合物

    公开(公告)号:US20060229363A1

    公开(公告)日:2006-10-12

    申请号:US11424623

    申请日:2006-06-16

    申请人: Ernest Hamanaka

    发明人: Ernest Hamanaka

    摘要: The present invention is directed at substituted heteroaryl and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.

    摘要翻译: 本发明涉及取代的杂芳基和苯基氨磺酰基化合物,含有这些化合物的药物组合物以及这些化合物如过氧化物酶体增殖物激活受体(PPAR)激动剂的用途。 PPARα激活剂,含有这些化合物的药物组合物以及使用这些化合物来提高某些血浆脂质水平,包括高密度脂蛋白胆固醇,并降低某些其他血浆脂质水平如LDL-胆固醇和甘油三酸酯,并因此治疗疾病 在哺乳动物,包括人类中,低水平的HDL胆固醇和/或高水平的LDL-胆固醇和甘油三酸酯如动脉粥样硬化和心血管疾病加剧。 该化合物也可用于治疗反能动物中的负能量平衡(NEB)和相关疾病。