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    Articulated custom ankle-foot orthosis systems
    6.
    发明申请
    Articulated custom ankle-foot orthosis systems 失效
    铰接定制脚踝矫形器系统

    公开(公告)号：US20050096576A1

    公开(公告)日：2005-05-05

    申请号：US10968603

    申请日：2004-10-18

    申请人： Ernesto Castro

    发明人： Ernesto Castro

    IPC分类号： A61F5/00 ,  A61F5/01

    CPC分类号： A61F5/0127

    摘要： A custom articulated ankle-foot orthosis (AFO) system is disclosed that is formed on a cast of the wearer's foot. It has an adjustably tightenable calf section hingedly connected to an adjustably tightenable foot section. It is made of thermally formable plastic sheet, is lined inside and outside, and is padded inside. The brace permits dorsal/plantar flexion while supporting the ankle against supination and pronation. The apparatus and methods of manufacture are disclosed.

    摘要翻译： 公开了一种定制的铰接脚踝足矫形器（AFO）系统，其形成在佩戴者的脚的铸件上。 它具有可调节紧固的小腿部分，铰接地连接到可调节地紧固的脚部。 由热成型塑料片制成，内衬内衬，内衬。 支架允许背侧/足底屈曲，同时支撑踝关节抵抗和旋转。 公开了装置和制造方法。

    Specific antibody fragments for the human carcinoembryonic antigen (cea)
    7.
    发明申请
    Specific antibody fragments for the human carcinoembryonic antigen (cea) 审中-公开
    人癌胚抗原（cea）的特异性抗体片段

    公开(公告)号：US20050158322A1

    公开(公告)日：2005-07-21

    申请号：US10511794

    申请日：2003-04-28

    申请人： Jorge Gailondo Cowley ,  Marta Avila ,  Freya de los Milagros Almeida ,  Boris Ernesto Castro ,  Hanssel Garcia ,  Lourdes Tatiana Navarro ,  Luis Javier Lopez ,  Jose Alberto Alvarez ,  Raquel Segui

    发明人： Jorge Gailondo Cowley ,  Marta Avila ,  Freya de los Milagros Almeida ,  Boris Ernesto Castro ,  Hanssel Garcia ,  Lourdes Tatiana Navarro ,  Luis Javier Lopez ,  Jose Alberto Alvarez ,  Raquel Segui

    IPC分类号： A61K39/00 ,  A61K39/39 ,  A61K47/48 ,  C07K14/22 ,  C07K16/30 ,  A61K39/395 ,  A01H1/00 ,  C12N15/82 ,  C12N5/06

    CPC分类号： C07K14/22 ,  C07K16/3007 ,  C07K2317/622 ,  C07K2317/626

    摘要： The invention refers to mono- and divalent (diabody) single chain Fv (scFv) antibody fragments, obtained by recombinant DNA techniques from the anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) CB/ior-CEA.1. This antibody has high affinity for CEA and is employed in the diagnosis and follow-up of human colorectal tumors. As the original Mab, the monovalent fragment and the diabody exhibit high affinity for human CEA and recognize an epitope dependent of carbohydrate conservation. The monovalent scFv fragment and the diabody have affinity constants for CEA of (5.0±0.4)×109 L mol−1 and (2.8±0.3)×1010 L mol−1, respectively. These two fragments do not show cross reactivity with human normal cells and tissues, exception made of the normal colonic mucosa, where CEA is occasionally present. The fragments can be produced through the expression in recombinant microorganisms, starting from the cloning of the encoding variable region nucleic acid sequences obtained from the hybridoma that produces Mab CB/ior-CEA.1. As the original Mab, the monovalent scFv and the diabody have the ability to identify in vivo cells that produce human CEA and grow as tumors in mice. The monovalent scFv and the diabody have a molecular size 5 and 2.5 times lower, respectively, than the mouse Mab, and do not have Fc domains, fact this that confers them the potential to better penetrate tissues in vivo and to be less immunogenic in man.

    摘要翻译： 本发明涉及通过来自抗癌胚抗原（CEA）单克隆抗体（Mab）CB / i-CEA.1的重组DNA技术获得的单价和二价（双抗体）单链Fv（scFv）抗体片段。 该抗体对CEA具有高亲和力，用于诊断和追踪人结肠直肠肿瘤。 作为原始的Mab，单价片段和双抗体对人CEA表现出高亲和力，并识别依赖于碳水化合物保护的表位。 单价scFv片段和双抗体对于（5.0±0.4）×10 9 L mol -1 -1和（2.8±0.3）×10 10 -1的CEA具有亲和力常数， / SUP> L mol 。 这两个片段不显示与人正常细胞和组织的交叉反应性，例外是正常结肠粘膜，其中CEA偶尔存在。 通过从产生Mab CB / i-CEA.1的杂交瘤获得的编码可变区核酸序列的克隆开始，可以通过重组微生物中的表达产生片段。 作为原始的Mab，单价scFv和双抗体具有鉴定产生人CEA的体内细胞并在小鼠中作为肿瘤生长的能力。 单价scFv和双抗体分别具有比小鼠Mab低5和2.5倍的分子量，并且不具有Fc结构域，事实上，这赋予它们在体内更好地穿透组织的潜力并且在人中具有较少的免疫原性 。

    Semi-Custom Ankle Brace System
    8.
    发明申请
    Semi-Custom Ankle Brace System 审中-公开
    半定制踝支撑系统

    公开(公告)号：US20070203441A1

    公开(公告)日：2007-08-30

    申请号：US11742422

    申请日：2007-04-30

    申请人： Ernesto Castro

    发明人： Ernesto Castro

    IPC分类号： A61F5/00

    CPC分类号： A61F5/0111

    摘要： Disclosed are methods and apparatus of semi-custom ankle brace systems adapted to be heat-formed onto a patient's foot. The system laces around the lower calf, ankle, heel, and arch, and also provides compression and assists the unitary ankle support in preventing pronation, suppination, and plantarflexion. The boot is custom heat-molded to the end user by heating it to about one-hundred-eighty degrees and then applying it to the patient's foot while it cools. The system comprises a unitary, heat-moldable ankle and full arch support encased in soft inner and outer linings. The inner lining, outer lining, and unitary ankle support form a toeless boot with minimum bulk.

    摘要翻译： 公开了适于被热成型到患者脚上的半定制踝关节支撑系统的方法和装置。 系统围绕下小腿，脚踝，脚跟和脚弓，并提供压缩和协助整体的脚踝支持，以防止旋前，支配和跖屈。 通过将其加热至约百八十度，然后将其在冷却时将其应用于患者的脚，将靴子定制为热成型至最终用户。 该系统包括一体式，可热模制的脚踝和全拱形支撑，其包裹在软内衬和外衬中。 内衬，外衬和单一脚踝支撑形成无花靴，体积最小。