-
公开(公告)号：US11896636B2
公开(公告)日：2024-02-13
申请号：US14130899
申请日：2012-07-06
申请人： Andrew Geall , Ethan Settembre
发明人： Andrew Geall , Ethan Settembre
IPC分类号： A61K39/245 , A61K39/23 , A61K35/76 , A61K35/763 , A61K39/12 , A61K39/00
CPC分类号： A61K35/763 , A61K35/76 , A61K39/12 , A61K39/23 , A61K39/245 , A61K2039/5258 , A61K2039/53 , A61K2039/55566 , A61K2039/70 , C12N2710/16134 , C12N2750/14223 , C12N2750/14234 , C12N2770/36143
摘要： This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
-
公开(公告)号：US09744228B2
公开(公告)日：2017-08-29
申请号：US13639820
申请日：2011-04-07
IPC分类号： A61K39/00 , A61K39/23 , C07K14/005 , C12N7/00
CPC分类号： A61K39/23 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2830/20 , C12N2830/34 , Y02A50/412
摘要： The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
-
公开(公告)号：US20230252381A1
公开(公告)日：2023-08-10
申请号：US18002973
申请日：2021-06-25
发明人： Allen BOLLANDS , Martina SCIONTI , Dirk HOFMANN , Ethan SETTEMBRE
IPC分类号： G06Q10/0631 , G06Q10/087 , G16H40/20 , G16H50/80
CPC分类号： G06Q10/06315 , G06Q10/087 , G16H40/20 , G16H50/80
摘要： A method of selectively providing access to an inventory of pre-pandemic vaccines is disclosed. The method includes identifying at least two Influenza Viruses of Pandemic Potential (IVPP) to provide available vaccines; determining a stockpile requirement for vaccines against selected IVPPs among the at least two IVPPs; obtaining finished vaccines against each of the selected IVPPs; storing an inventory of finished vaccines against each of the selected IVPPs; providing the finished vaccines against at least one of the selected IVPPs in response to an access request; and periodically obtaining further finished vaccines against one or more of the selected IVPPs and adding the further finished vaccines to the inventory of finished vaccines. Additionally disclosed are methods of selecting the inventory of finished vaccines for an adaptive vaccine stockpile.
-
公开(公告)号：US10030052B2
公开(公告)日：2018-07-24
申请号：US14234648
申请日：2012-07-25
IPC分类号： C07K14/005 , A61K39/23 , C07K16/08 , G01N33/569 , A61K39/12 , A61K39/00
摘要： The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
-
公开(公告)号：US20140227346A1
公开(公告)日：2014-08-14
申请号：US14130899
申请日：2012-07-06
申请人： Andrew Geall , Ethan Settembre
发明人： Andrew Geall , Ethan Settembre
IPC分类号： A61K35/76
CPC分类号： A61K35/763 , A61K35/76 , A61K39/12 , A61K39/23 , A61K39/245 , A61K2039/5258 , A61K2039/53 , A61K2039/55566 , A61K2039/70 , C12N2710/16134 , C12N2750/14223 , C12N2750/14234 , C12N2770/36143
摘要： This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
摘要翻译： 本发明一般涉及包含RNA组分和多肽组分的免疫原性组合物。 以两种不同形式递送抗原的免疫原性组合物 - 来自病原体的第一抗原，RNA编码形式; 和来自多种形式的不同病原体的第二抗原有效诱导对两种病原体的免疫应答。
-
公开(公告)号：US20130171185A1
公开(公告)日：2013-07-04
申请号：US13808157
申请日：2011-07-05
IPC分类号： C07K14/08 , A61K39/295
CPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , C07K14/08 , C07K2319/00 , C12N7/00 , C12N2770/16022 , C12N2770/16023
摘要： The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
摘要翻译： 本发明涉及含有第一诺如病毒株的VP1的S-结构域和含有第二诺如病毒株的VP1的至少一部分的P结构域的嵌合诺如病毒VP1蛋白质。 本发明还涉及编码嵌合VP1蛋白的核酸，含有嵌合诺如病毒VP1蛋白的病毒样颗粒和免疫原性组合物。
-
7.发明申请COMPOSITIONS AND METHODS FOR ASSESSING FUNCTIONAL IMMUNOGENICITY OF PARVOVIRUS VACCINES 审中-公开用于评估寄生虫疫苗功能性免疫原性的组合物和方法公开(公告)号：US20140170187A1
公开(公告)日：2014-06-19
申请号：US14234648
申请日：2012-07-25
IPC分类号： C07K14/005 , G01N33/569 , A61K39/23
CPC分类号： C07K14/005 , A61K39/12 , A61K39/23 , A61K2039/5258 , A61K2039/55566 , C07K16/081 , C07K2317/34 , C12N2750/14222 , C12N2750/14234 , G01N33/56983 , G01N2333/015 , G01N2469/20
摘要： The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
摘要翻译： 本发明涉及突变型细小病毒VP1独特区域多肽，包含此类多肽的组合物，制备此类组合物的方法，以及鉴定细小病毒中和抗体可能存在的方法，以及用于评估细小病毒疫苗的功能免疫原性的方法和 测量效力的相关性以评估细小病毒感染的治疗。
-
公开(公告)号：US20130273109A1
公开(公告)日：2013-10-17
申请号：US13639820
申请日：2011-04-07
IPC分类号： A61K39/23
CPC分类号： A61K39/23 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2830/20 , C12N2830/34 , Y02A50/412
摘要： The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
摘要翻译： 本发明提供了产生细小病毒VP1 / VP2病毒样颗粒（VLP）的方法。 本发明还提供了用于纯化包含VLP的细小病毒VLP和免疫原性组合物的方法。 本发明还包括编码细小病毒VP1和VP2的重组核酸分子以及含有重组核酸的宿主细胞。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.019 秒)
