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公开(公告)号:US20130171185A1
公开(公告)日:2013-07-04
申请号:US13808157
申请日:2011-07-05
IPC分类号: C07K14/08 , A61K39/295
CPC分类号: C07K14/005 , A61K39/12 , A61K39/295 , C07K14/08 , C07K2319/00 , C12N7/00 , C12N2770/16022 , C12N2770/16023
摘要: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
摘要翻译: 本发明涉及含有第一诺如病毒株的VP1的S-结构域和含有第二诺如病毒株的VP1的至少一部分的P结构域的嵌合诺如病毒VP1蛋白质。 本发明还涉及编码嵌合VP1蛋白的核酸,含有嵌合诺如病毒VP1蛋白的病毒样颗粒和免疫原性组合物。
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公开(公告)号:US08685411B2
公开(公告)日:2014-04-01
申请号:US11649191
申请日:2007-01-03
CPC分类号: C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2720/12322
摘要: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.
摘要翻译: 本发明涉及可以包含抗轮状病毒感染的亚基疫苗的新型重组多肽抗原。 此外,本发明涉及在诊断,治疗和预防轮状病毒感染中使用所述抗原的方法。
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公开(公告)号:US20130273109A1
公开(公告)日:2013-10-17
申请号:US13639820
申请日:2011-04-07
IPC分类号: A61K39/23
CPC分类号: A61K39/23 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2830/20 , C12N2830/34 , Y02A50/412
摘要: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
摘要翻译: 本发明提供了产生细小病毒VP1 / VP2病毒样颗粒(VLP)的方法。 本发明还提供了用于纯化包含VLP的细小病毒VLP和免疫原性组合物的方法。 本发明还包括编码细小病毒VP1和VP2的重组核酸分子以及含有重组核酸的宿主细胞。
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公开(公告)号:US09744228B2
公开(公告)日:2017-08-29
申请号:US13639820
申请日:2011-04-07
IPC分类号: A61K39/00 , A61K39/23 , C07K14/005 , C12N7/00
CPC分类号: A61K39/23 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2830/20 , C12N2830/34 , Y02A50/412
摘要: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
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公开(公告)号:US20110305727A1
公开(公告)日:2011-12-15
申请号:US12836931
申请日:2010-07-15
申请人: Kurt Swanson , Philip R. Dormitzer
发明人: Kurt Swanson , Philip R. Dormitzer
IPC分类号: A61K39/155 , C07H21/04 , A61P37/04 , C07K14/135
CPC分类号: C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C07K14/005 , C07K2317/76 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C07K2319/73 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
摘要翻译: 本发明涉及包含RSV F蛋白的免疫原性组合物,用于制备含有RSV F蛋白质外结构域多肽的组合物的方法,以及编码经工程化的RSV F蛋白的某些工程改造的RSV F蛋白和核酸。 使用该方法制备的组合物可以含有主要或单一所需形式和构象的RSV F蛋白质外结构域多肽。 本发明还涉及诱导对RSV F的免疫应答的方法。
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