公开(公告)号：US08410434B1

公开(公告)日：2013-04-02

申请号：US13235033

申请日：2011-09-16

Applicant: Eugene Moskovets ,  Alexander R. Ivanov ,  Vladimir Doroshenko

Inventor： Eugene Moskovets ,  Alexander R. Ivanov ,  Vladimir Doroshenko

IPC: H01J49/10

CPC classification number: G01N30/7233 ,  G01N30/30 ,  G01N2030/3084 ,  H01J49/0468 ,  H01J49/165

Abstract: A liquid chromatography interface is provided having an integrated column/ESI tip assembly including a liquid chromatography separation column, an ESI tip for generating ions having at least one emitting channel, and a temperature-controlled enclosure surrounding the liquid chromatography separation column. The enclosure has at least one opening and the ESI tip is exposed outside the enclosure through the opening. The enclosure has a heating or cooling device providing a substantially homogeneous distribution of temperature throughout an internal space of the enclosure where the liquid chromatography separation column is disposed. The enclosure includes at least one gas flow mixing element to permit heat exchange by directing a flow of gas toward the ESI tip. The integrated column/ESI tip assembly resides within a thermo-stabilized volume of substantially the same temperature from an entrance of the liquid chromatography separation column to the outlet of the ESI tip.

Abstract translation: 提供液相色谱界面，其具有包括液相色谱分离柱，用于产生具有至少一个发射通道的离子的ESI尖端和围绕液相色谱分离柱的温度控制的外壳的集成柱/ ESI尖端组件。 外壳具有至少一个开口，ESI端头通过开口暴露在外壳外部。 外壳具有加热或冷却装置，其在设置液相色谱分离柱的外壳的内部空间中提供基本上均匀的温度分布。 外壳包括至少一个气流混合元件，以通过将气流引向ESI尖端来允许热交换。 集成柱/ ESI端头组件位于从液相色谱分离柱的入口到ESI尖端的出口基本上相同温度的热稳定体积内。

公开(公告)号：US20130068946A1

公开(公告)日：2013-03-21

申请号：US13235033

申请日：2011-09-16

Applicant: Eugene MOSKOVETS ,  Alexander R. Ivanov ,  Vladimir Doroshenko

Inventor： Eugene MOSKOVETS ,  Alexander R. Ivanov ,  Vladimir Doroshenko

IPC: H01J49/26 ,  G01N30/84

CPC classification number: G01N30/7233 ,  G01N30/30 ,  G01N2030/3084 ,  H01J49/0468 ,  H01J49/165

Abstract: A liquid chromatography interface is provided having an integrated column/ESI tip assembly including a liquid chromatography separation column, an ESI tip for generating ions having at least one emitting channel, and a temperature-controlled enclosure surrounding the liquid chromatography separation column. The enclosure has at least one opening and the ESI tip is exposed outside the enclosure through the opening. The enclosure has a heating or cooling device providing a substantially homogeneous distribution of temperature throughout an internal space of the enclosure where the liquid chromatography separation column is disposed. The enclosure includes at least one gas flow mixing element to permit heat exchange by directing a flow of gas toward the ESI tip. The integrated column/ESI tip assembly resides within a thermo-stabilized volume of substantially the same temperature from an entrance of the liquid chromatography separation column to the outlet of the ESI tip.

Abstract translation: 提供液相色谱界面，其具有包括液相色谱分离柱，用于产生具有至少一个发射通道的离子的ESI尖端和围绕液相色谱分离柱的温度控制的外壳的集成柱/ ESI尖端组件。 外壳具有至少一个开口，ESI端头通过开口暴露在外壳外部。 外壳具有加热或冷却装置，其在设置液相色谱分离柱的外壳的内部空间中提供基本上均匀的温度分布。 外壳包括至少一个气流混合元件，以通过将气流引向ESI尖端来允许热交换。 集成柱/ ESI端头组件位于从液相色谱分离柱的入口到ESI尖端的出口基本上相同温度的热稳定体积内。

公开(公告)号：US20080067349A1

公开(公告)日：2008-03-20

申请号：US11441177

申请日：2006-05-26

Applicant: Eugene Moskovets ,  Vladimir M. Doroshenko

Inventor： Eugene Moskovets ,  Vladimir M. Doroshenko

IPC: H01J49/40

CPC classification number: H01J49/401 ,  H01J49/009

Abstract: A system and method for mass analysis of ions. The system includes an orthogonal acceleration time-of-flight mass analyzer having at least two channels configured to receive respective groups of ions from respective ion sources and having a field-free section configured to mass-separate ions during flight time. The groups of ions are directed to different ones of the channels of the mass analyzer for mass analysis of the respective groups of ions, and at least a part of the field-free section is shared between the channels. The method introduces the ions into an orthogonal acceleration time-of-flight mass analyzer, directs groups of ions from respective ones of the two sources into different channels of the mass analyzer, and simultaneously mass-analyzes the groups of ions from the different channels.

Abstract translation: 用于离子质量分析的系统和方法。 该系统包括正交加速飞行时间质量分析器，其具有至少两个通道，其被配置为从相应离子源接收相应的离子组，并且具有配置成在飞行时间内质量分离离子的无场区段。 离子组被引导到质量分析器的不同通道，用于各组离子的质量分析，并且至少一部分无场区段在通道之间共享。 该方法将离子引入正交加速度飞行时间质量分析仪，将来自两个源中的各个离子的群组引导到质量分析器的不同通道，同时对来自不同通道的离子群进行质量分析。