公开(公告)号：US5324640A

公开(公告)日：1994-06-28

申请号：US99467

申请日：1987-09-21

申请人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

发明人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

IPC分类号： C12N15/09 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12R1/91 ,  C07H15/12 ,  C07K3/00 ,  C12N1/16 ,  C12N1/18 ,  C12N1/21 ,  C12N7/00 ,  C12P19/34

CPC分类号： C07K14/5409

摘要： A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the polypeptide portion of mature human B-cell differentiation factor and the leader peptide were revealed. The method for producing human B-cell differentiation factor by a recombinant gene technology was also provided.

摘要翻译： 提供了编码人B细胞分化因子的cDNA和染色体DNA，并且所述DNA的全部核苷酸序列以及成熟人B细胞分化因子和前导肽的多肽部分的全部氨基酸序列分别为 透露 还提供了通过重组基因技术生产人B细胞分化因子的方法。

公开(公告)号：US5530098A

公开(公告)日：1996-06-25

申请号：US257525

申请日：1994-06-08

申请人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

发明人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

IPC分类号： C12N15/09 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12R1/91 ,  C07K14/715 ,  C12N15/24

CPC分类号： C07K14/5409

摘要： A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the polypeptide portion of mature human B-cell differentiation factor and the leader peptide were revealed. The method for producing human B-cell differentiation factor by a recombinant gene technology was also provided.

摘要翻译： 提供了编码人B细胞分化因子的cDNA和染色体DNA，并且所述DNA的全部核苷酸序列以及成熟人B细胞分化因子和前导肽的多肽部分的全部氨基酸序列分别为 透露 还提供了通过重组基因技术生产人B细胞分化因子的方法。

公开(公告)号：US5416201A

公开(公告)日：1995-05-16

申请号：US913276

申请日：1986-09-30

申请人： Tasuku Honjo ,  Eva Severinson

发明人： Tasuku Honjo ,  Eva Severinson

IPC分类号： C12N15/09 ,  A61K39/395 ,  C07H21/04 ,  C07K14/00 ,  C07K14/54 ,  C12N1/00 ,  C12N15/00 ,  C12N15/24 ,  C12P21/02 ,  A61K38/00 ,  C07H15/12 ,  C07K1/00 ,  C12N1/21 ,  C12P19/34

CPC分类号： C07K14/5406

摘要： Mouse IgG.sub.1 inducing factor and the DNA that codes for the same were isolated by using a novel genetic technique, and their structures determined by the dideoxy chain termination method. The mouse IgG.sub.1 inducing factor obtained by the method of this invention has activity to improve immune response in living bodies and are hence useful for the treatment and prevention of infectious diseases, AIDS, functional immunodeficiency and the like. This factor, or part of its amino acid sequence, may also be used for the preparation of antibody against the same. In addition, it is possible to use this factor as a model for the synthesis of other polypeptides having similar structures, and for many other purposes.

摘要翻译： 通过使用新型遗传技术分离小鼠IgG1诱导因子和编码相同的DNA，并通过双脱氧链终止法测定其结构。 通过本发明方法获得的小鼠IgG1诱导因子具有改善活体免疫应答的活性，因此可用于治疗和预防感染性疾病，艾滋病，功能性免疫缺陷等。 该因子或其部分氨基酸序列也可用于制备抗相同抗体的抗体。 此外，可以将该因子用作合成具有相似结构的其它多肽的模型，并且用于许多其它目的。