公开(公告)号：US07238354B2

公开(公告)日：2007-07-03

申请号：US11193512

申请日：2005-08-01

申请人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

发明人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7155 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor α chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor α chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

摘要翻译： 本发明提供与人白细胞介素-5受体α链特异性反应的单克隆抗体和人源化抗体。 本发明还提供产生抗体的杂交瘤和转化体，单克隆抗体和人源化抗体，通过这些抗体免疫学检测白细胞介素-5受体α链的方法，以及用于诊断和治疗慢性疾病的方法 支气管哮喘通过单克隆抗体和人源化抗体。 本发明可用于诊断或治疗慢性支气管哮喘等疾病。

公开(公告)号：US07179464B2

公开(公告)日：2007-02-20

申请号：US10283349

申请日：2002-10-29

申请人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

发明人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7155 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor α chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor α chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

摘要翻译： 本发明提供与人白细胞介素-5受体α链特异性反应的单克隆抗体和人源化抗体。 本发明还提供产生抗体的杂交瘤和转化体，单克隆抗体和人源化抗体，通过这些抗体免疫学检测白细胞介素-5受体α链的方法，以及用于诊断和治疗慢性疾病的方法 支气管哮喘通过单克隆抗体和人源化抗体。 本发明可用于诊断或治疗慢性支气管哮喘等疾病。

公开(公告)号：US06538111B1

公开(公告)日：2003-03-25

申请号：US09434122

申请日：1999-11-05

申请人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

发明人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

IPC分类号： C07K1628

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7155 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor &agr; chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor &agr; chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

公开(公告)号：US5324640A

公开(公告)日：1994-06-28

申请号：US99467

申请日：1987-09-21

申请人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

发明人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

IPC分类号： C12N15/09 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12R1/91 ,  C07H15/12 ,  C07K3/00 ,  C12N1/16 ,  C12N1/18 ,  C12N1/21 ,  C12N7/00 ,  C12P19/34

CPC分类号： C07K14/5409

摘要： A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the polypeptide portion of mature human B-cell differentiation factor and the leader peptide were revealed. The method for producing human B-cell differentiation factor by a recombinant gene technology was also provided.

摘要翻译： 提供了编码人B细胞分化因子的cDNA和染色体DNA，并且所述DNA的全部核苷酸序列以及成熟人B细胞分化因子和前导肽的多肽部分的全部氨基酸序列分别为 透露 还提供了通过重组基因技术生产人B细胞分化因子的方法。

公开(公告)号：US5015863A

公开(公告)日：1991-05-14

申请号：US469857

申请日：1990-01-23

申请人： Eiki Takeshima ,  Kiyoshi Takatsu ,  Norio Asano ,  Masahiro Hozumi

发明人： Eiki Takeshima ,  Kiyoshi Takatsu ,  Norio Asano ,  Masahiro Hozumi

IPC分类号： G21F1/12 ,  G21F3/00 ,  G21F5/10

CPC分类号： G21F5/10 ,  G21F1/12 ,  G21F3/00

摘要： This invention relates to a shielding material used as a radiation shield of a container containing radioactive wastes. A radiation shield with an excellent heat-transferring property is fabricated from composite particles (A) obtained by coating core particles (a) of radiation-shielding property with a metal (b) of high thermal conductivity. Composite particles are formed into a certain shape of radiation shield by hot-press forming or other forming or packed into the internal space of radioactive waste container or the shield container cavity to compose a radiation shield.

公开(公告)号：US20050272918A1

公开(公告)日：2005-12-08

申请号：US11193512

申请日：2005-08-01

申请人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

发明人： Masamichi Koike ,  Akiko Furuya ,  Kazuyasu Nakamura ,  Akihiro Iida ,  Hideharu Anazawa ,  Nobuo Hanai ,  Kiyoshi Takatsu

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/24 ,  C07K16/28 ,  C12N5/18 ,  C12P21/08

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7155 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor α chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor α chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

摘要翻译： 本发明提供与人白细胞介素-5受体α链特异性反应的单克隆抗体和人源化抗体。 本发明还提供产生抗体的杂交瘤和转化体，单克隆抗体和人源化抗体，通过这些抗体免疫学检测白细胞介素-5受体α链的方法，以及用于诊断和治疗慢性疾病的方法 支气管哮喘通过单克隆抗体和人源化抗体。 本发明可用于诊断或治疗慢性支气管哮喘等疾病。

公开(公告)号：US06890648B2

公开(公告)日：2005-05-10

申请号：US09870037

申请日：2001-05-30

申请人： Hirokazu Yano ,  Yoshikatsu Udagawa ,  Minoru Kiyotsuka ,  Kiyoshi Takatsu

发明人： Hirokazu Yano ,  Yoshikatsu Udagawa ,  Minoru Kiyotsuka ,  Kiyoshi Takatsu

IPC分类号： C09D5/08 ,  B32B5/16 ,  B32B15/08 ,  B32B27/00 ,  B32B27/36

CPC分类号： C09D5/084 ,  Y10T428/12569 ,  Y10T428/258 ,  Y10T428/259 ,  Y10T428/31511 ,  Y10T428/3154 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31786

摘要： A paint composition containing a corrosion inhibitor A prepared from porous silica particles, to which Ca ion is bonded by ion-exchange, and a polyphosphate B preferably at an A/B weight ratio of 60/40 to 5/95 and at an A+B ratio of 5-150 parts by weight based on 100 parts by weight of resinous components. A base metal sheet is preferably one pre-treated with a chemical agent containing at least one fluoroacid. Since the polyphosphate B controls dissolution of Ca ion, an effect of Ca ion on corrosion inhibition is maintained over a long term. The painted metal sheet does not put harmful influences on the environment, since it does not contain chromium compounds.

摘要翻译： 含有通过离子交换键合Ca离子的多孔二氧化硅颗粒制备的腐蚀抑制剂A和优选以A / B重量比为60/40〜5/95的聚磷酸酯B和A + B比为5-150重量份，基于100重量份的树脂成分。 贱金属片优选用含有至少一种氟酸的化学试剂进行预处理。 由于多磷酸盐B控制Ca离子的溶解，因此长期保持Ca离子对腐蚀抑制的作用。 由于不含有铬化合物，所以涂上的金属片对环境没有有害影响。

公开(公告)号：US5530098A

公开(公告)日：1996-06-25

申请号：US257525

申请日：1994-06-08

申请人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

发明人： Tasuku Honjo ,  Kiyoshi Takatsu ,  Eva Severinson

IPC分类号： C12N15/09 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12R1/91 ,  C07K14/715 ,  C12N15/24

CPC分类号： C07K14/5409

摘要： A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the polypeptide portion of mature human B-cell differentiation factor and the leader peptide were revealed. The method for producing human B-cell differentiation factor by a recombinant gene technology was also provided.

摘要翻译： 提供了编码人B细胞分化因子的cDNA和染色体DNA，并且所述DNA的全部核苷酸序列以及成熟人B细胞分化因子和前导肽的多肽部分的全部氨基酸序列分别为 透露 还提供了通过重组基因技术生产人B细胞分化因子的方法。

公开(公告)号：US4908106A

公开(公告)日：1990-03-13

申请号：US340670

申请日：1989-04-20

申请人： Eiki Takeshima ,  Kiyoshi Takatsu ,  Youichi Kojima ,  Takahiro Fujii

发明人： Eiki Takeshima ,  Kiyoshi Takatsu ,  Youichi Kojima ,  Takahiro Fujii

IPC分类号： C25D5/54 ,  C25D5/08 ,  C25D7/00

CPC分类号： C25D5/08 ,  C25D7/00

摘要： Disclosed herein suspension electroplating of fine particles with metal. An electroplating operatively equipped with a cathode and anode is charged with a metallic ion-containing electrolyte and particles to be electroplated. The particles have a size of from 0.1 to 10 .mu.m. At least a part of the surface of each particle is conductive. Such a stationary circulating flow of a suspension of the particles in the electrolyte is formed in the bath that the particles are maintained in the suspended condition; the suspension is circulated substantially without coming in contact with the anode; the particles may have a chance of colliding with substantially all surface areas of the working surface of the cathode, and are repeatedly brought in collision with the cathode at a velocity with a normal component of from 0.6 to 6.0 m/min.; and a particle concentration of the suspension at the time of collision is from 30 to 55% by volume. When such a stationary flow has been formed, a current for electroplating is caused to pass, whereupon deposition of metal on the particles proceeds without deposition of the particles and metal on the cathode.

公开(公告)号：US5916767A

公开(公告)日：1999-06-29

申请号：US939727

申请日：1997-10-03

申请人： Kiyoshi Takatsu ,  Akira Tominaga ,  Satoshi Takagi ,  Yoshiyuki Murata

发明人： Kiyoshi Takatsu ,  Akira Tominaga ,  Satoshi Takagi ,  Yoshiyuki Murata

IPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/00 ,  C07K14/715 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/24 ,  C12P21/02 ,  C12R1/91 ,  C12N15/00

CPC分类号： C07K14/7155 ,  A61K38/00 ,  Y10S930/12

摘要： The invention provides an isolated cDNA sequence coding for murine interleukin 5 receptor, murine secretory interleukin 5 receptor, human interleukin 5 receptor, and human secretory interleukin 5 receptor and products including murine interleukin 5 receptor, murine secretory interleukin 5 receptor, and human interleukin 5 receptor which are produced using the isolated cDNA sequence. These products may be useful for a therapeutic agent for autoimmune disorders and diseases with eosinophilia in which human IL-5 is believed to be involved.

摘要翻译： 本发明提供编码鼠白细胞介素5受体，鼠分泌白细胞介素5受体，人白介素5受体和人分泌白细胞介素5受体的分离cDNA序列，包括鼠白细胞介素5受体，鼠分泌白细胞介素5受体和人白细胞介素5受体的产物 其使用分离的cDNA序列产生。 这些产品可用于自身免疫性疾病的治疗剂和与其相关的人IL-5的嗜酸性粒细胞增多的疾病。