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1.发明公开公开(公告)号：US20240245727A1
公开(公告)日：2024-07-25
申请号：US18604446
申请日：2024-03-13
发明人： Irina Kerkis , Alexandre Kerkis
IPC分类号： A61K35/28 , A61K9/00 , A61K35/30 , A61K35/32 , C12N5/071 , C12N5/0775 , C12N5/079 , C12N5/0793 , C12N5/0797
CPC分类号： A61K35/28 , A61K9/0019 , A61K35/30 , A61K35/32 , C12N5/0619 , C12N5/0621 , C12N5/0623 , C12N5/0664 , C12N5/0678 , C12N2500/25 , C12N2500/38 , C12N2500/84 , C12N2500/90 , C12N2501/385 , C12N2501/39 , C12N2501/392 , C12N2501/395 , C12N2506/1361 , C12N2533/76
摘要： The present disclosure relates to a cryopreserved pharmaceutical composition comprising immature dental pulp stem cells (IDPSCs) expressing CD13 and CD44 and methods of treating a neurological disease or condition comprising systemically administering to a subject a cryopreserved pharmaceutical composition comprising IDPSCs expressing CD13 and CD44. In some aspects, the IDPSCs in the cryopreserved pharmaceutical composition described herein further expresses beta-3-tubulin. In some aspects, the IDPSCs secrete brain-derived neurotrophic factor.
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公开(公告)号：US20230092739A1
公开(公告)日：2023-03-23
申请号：US17951082
申请日：2022-09-22
发明人： Irina Kerkis
IPC分类号： C12N5/0775 , C12N5/073 , A61K35/12 , A61K35/50 , A61K35/51
摘要： The present method relates to methods of expanding or increasing stem cell production obtained from donor samples. The methods preferably including the steps of harvesting cells from minimally manipulated tissue using multiply harvesting cycles to increase the number of obtained stem cells.
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公开(公告)号：US20200339954A1
公开(公告)日：2020-10-29
申请号：US16833151
申请日：2020-03-27
发明人： Irina Kerkis
IPC分类号： C12N5/0775 , C12N5/0793 , C12N5/071 , A61K35/30 , A61K35/32 , C12N5/0797 , A61K35/28 , A61K45/06 , C12N5/079
摘要： The present invention is directed to therapeutic multifunctional immature dental pulp stem cells (IDPSCs), and IDPSCs multi-lineage compositions. The invention is further directed to the use of IDPSCs and compositions to reduce the risk of and/or treat degenerative diseases or for other medicinal and aesthetic purposes.
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公开(公告)号：US20200095289A1
公开(公告)日：2020-03-26
申请号：US16485035
申请日：2018-02-09
发明人： Ana Marisa Chudzinski-Tavassi , Bárbara Athayde Vaz Galvão da Silva , Kerly Fernanda Mesquita Pasqualoto , Leo Kei Iwai , Rafael Marques Porto
摘要： The present invention relates to novel hybrid peptides developed from the combination of membrane surface protein peptide fragments present in anaplasmosis microorganisms, and in particular, bacteria of the species Anaplasma marginale. The present invention further relates to hybrid peptide sets, compositions and kits comprising such novel hybrid peptides, their uses and methods of inducing immune response. Each hybrid peptide, according to the present invention, comprises two or more peptide fragments of amino acid sequences as defined in the present invention linked together by means of a spacer element. The combined peptide fragments are protein peptide fragments of MSP1, MSP1a, MSP1b, MSP2, MSP2-HRV, MSP3, OMP7, OMP8, VirB9 and VirB10.
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公开(公告)号：US20220211765A1
公开(公告)日：2022-07-07
申请号：US17700458
申请日：2022-03-21
IPC分类号： A61K35/32 , A61P25/28 , A61K9/00 , C12N5/0775
摘要： The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.
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公开(公告)号：US20210236557A1
公开(公告)日：2021-08-05
申请号：US17049956
申请日：2019-04-30
IPC分类号： A61K35/28 , C07K14/705 , C07K14/78 , C12N5/0775
摘要： The present invention relates to the field of adult stem cells of embryonic neural crest origin, in particular, multifunctional immature dental pulp stem cells (IDPSCs). The invention discloses useful compositions and methods for the prevention or treatment of a wide range of diseases that lead to or derived from bone marrow failure (BMF), Acute Radiation Syndromes, or chemical injury through the use of isolated IDPSC population with minimal in vitro manipulation.
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公开(公告)号：US20220193141A1
公开(公告)日：2022-06-23
申请号：US17562797
申请日：2021-12-27
发明人： Irina Kerkis , Alexandre Kerkis
IPC分类号： A61K35/28 , A61K9/00 , C12N5/0775 , A61K35/30 , C12N5/0793 , C12N5/0797 , C12N5/071 , A61K35/32 , C12N5/079
摘要： The present disclosure relates to a cryopreserved pharmaceutical composition comprising immature dental pulp stem cells (IDPSCs) expressing SOX-1 and SOX-2 and methods of treating a neurological disease or condition comprising systemically administering to a subject a cryopreserved pharmaceutical composition comprising IDPSCs expressing SOX-1 and SOX-2.
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8.发明申请公开(公告)号：US20190010462A1
公开(公告)日：2019-01-10
申请号：US16125699
申请日：2018-09-08
IPC分类号： C12N5/0775 , A61K35/32 , C07K14/705 , A61K9/00
摘要： The invention provides a method of producing human immature dental pulp stem cells (hIDPSCs) expressing CD44 and CD13 and lacking expression of CD146. The invention also provides compositions for use in the treatment of a neurological disease or condition selected from the group consisting of Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis (ALS), stroke, autoimmune encephalomyelitis, diabetic neuropathy, glaucomatous neuropathy, Alzheimer's disease, Huntington's disease (HD), autism, schizophrenia, stroke, ischemia, a motor disorder, and a convulsive disorder.
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9.发明申请公开(公告)号：US20190000887A1
公开(公告)日：2019-01-03
申请号：US16125702
申请日：2018-09-08
摘要： The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.
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10.发明申请Polynucleotide, Polypeptide with Immunosuppressive Activity, Expression Cassette, Expression Vector, Host Cell, Pharmaceutical Composition, Methods for Producing a Polypeptide with Immunosuppressive Activity and for Preventing or Treating Conditions That Require Immunosuppression, and Use of a Polypeptide 审中-公开多核苷酸，具有免疫抑制活性的多肽，表达盒，表达载体，宿主细胞，药物组合物，产生具有免疫抑制活性的多肽的方法和用于预防或治疗需要免疫抑制的病症和使用多肽公开(公告)号：US20160311869A1
公开(公告)日：2016-10-27
申请号：US15031936
申请日：2014-10-24
申请人： FUNDAÇÃO BUTANTAN
发明人： Denise V. Tambourgi , Giselle Pidde Queiroz , Osvaldo Augusto Brazil Esteves Sant'Anna , Fábio Carlos Magnoli , Ogari de Castro Pacheco
IPC分类号： C07K14/46
CPC分类号： C07K14/46 , A61K38/00 , A61K39/001 , A61K39/38 , C07K14/4713
摘要： This invention refers to polynucleotides and non-hemorrhagic and non-immunogenic polypeptides of selective immunosuppressive activity on production of antibodies to antigens of different natures. The polypeptides described herein are useful for preparing pharmaceutical compositions for prevention or treatment of conditions that require immunosuppression, preferably, inflammatory, autoimmune, allergic and infectious diseases and rejection to transplanted organs.
摘要翻译： 本发明涉及针对不同性质的抗原产生抗体的选择性免疫抑制活性的多核苷酸和非出血性和非免疫原性多肽。 本文所述的多肽可用于制备用于预防或治疗需要免疫抑制，优选炎性，自身免疫，过敏和感染性疾病以及移植器官排斥的病症的药物组合物。
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