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    Thermo-reversible polymer for intralumenal implant
    2.
    发明授权
    Thermo-reversible polymer for intralumenal implant 有权
    用于腔内植入物的热可逆聚合物

    公开(公告)号：US07485317B1

    公开(公告)日：2009-02-03

    申请号：US09890799

    申请日：1999-02-05

    申请人： Yuichi Murayama ,  Fernando Vinuela ,  Yuichi Mori

    发明人： Yuichi Murayama ,  Fernando Vinuela ,  Yuichi Mori

    IPC分类号： A61F2/02 ,  A61K9/14

    CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K47/32 ,  A61L24/001 ,  A61L24/0031 ,  A61L24/046 ,  A61L24/06 ,  A61L24/08 ,  C08L71/02

    摘要： An intralumenal implant material, which comprises, a polymer having a sol-gel transition temperature in an aqueous solution thereof, shows a substantial water-insolubility at a temperature higher than the sol-gel transition temperature, and shows a thermo-reversible water-solubility at a temperature lower than the sol-gel transition temperature. Such an intralumenal implant is capable to be endovascularly or percutaneuosly delivered into a vascular lumen in a liquid state at the temperature lower than the sol-gel transition temperature, is capable to be instantly converted into a gel state in the vascular lumen at the blood temperature higher than the sol-gel transition temperature and is capable of occluding aneurysms, vascular tumors or vascular malformation. Such intralumenal implant material shows excellent biocompatibility and mechanical matching for the vascular tissue and the surrounding tissue because it is a highly water-containing hydrogel. In addition, biologically active substances for promoting a prompt neo-endothelium formation and/or endothelialization can be easily incorporated into such an intralumenal implant material.

    摘要翻译： 包括在其水溶液中具有溶胶 - 凝胶转变温度的聚合物的体内植入材料在高于溶胶 - 凝胶转变温度的温度下显示出基本的水不溶性，并且显示出热可逆水溶性 在低于溶胶 - 凝胶转变温度的温度下。 这种腔内植入物能够在低于溶胶 - 凝胶转变温度的温度下血管内或经口交叉递送到液体状态的血管腔中，能够立即在血液温度下在血管腔中转化为凝胶状态 高于溶胶 - 凝胶转变温度，并且能够阻塞动脉瘤，血管肿瘤或血管畸形。 这种腔内植入材料由于是高度含水的水凝胶，因此显示出优异的血管组织和周围组织的生物相容性和机械匹配性。 此外，用于促进迅速的新内皮细胞形成和/或内皮细胞化的生物活性物质可以容易地并入到这种体内植入材料中。

    Bioabsorbable polymeric implants and a method of using the same to create occlusions
    4.
    发明授权
    Bioabsorbable polymeric implants and a method of using the same to create occlusions 有权
    生物可吸收的聚合物植入物及其使用方法产生闭塞

    公开(公告)号：US08388643B2

    公开(公告)日：2013-03-05

    申请号：US11198587

    申请日：2005-08-05

    申请人： Yuichi Murayama ,  Fernando Vinuela

    发明人： Yuichi Murayama ,  Fernando Vinuela

    IPC分类号： A61M29/00 ,  B05D7/00 ,  B28B19/00 ,  C23C18/00 ,  C23C20/00 ,  C23C28/00 ,  C23C14/14 ,  C23C14/16 ,  A61N1/362 ,  A61B1/00

    CPC分类号： A61L31/18 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/00004 ,  A61B2017/1205 ,  A61K38/00 ,  A61L31/043 ,  A61L31/06 ,  A61L31/082 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2430/36 ,  C08L67/04

    摘要： A embolic, bioabsorbable polymeric material (BPM) is incorporated into a coil to improve long-term anatomic results in the endovascular treatment of intracranial aneurysms. The material includes at least one biocompatible and bioabsorbable polymer and growth factors, is carried by hybrid bioactive coils and is used to accelerate histopathologic transformation of unorganized clot into fibrous connective tissue in aneurysms. An endovascular cellular manipulation and inflammatory response are elicited from implantation in a vascula location. Thrombogenicity of the biocompatible and bioabsorbable polymer is controlled by the composition of or proportioning the ratio of constituents making up the polymer. The biocompatible and bioabsorbable polymer is at least one polymer selected from the group consisting of polyglycolic acid, polyglycolic acid/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide. Polydioxanone, polycarbonates, and polyanhydrides.

    摘要翻译： 将栓塞，生物可吸收聚合物材料（BPM）并入线圈中以改善颅内动脉瘤血管内治疗中的长期解剖结果。 该材料包括至少一种生物相容性和生物可吸收的聚合物和生长因子，由混合生物活性线圈承载，并用于加速组织病理转化的无组织的凝块进入动脉瘤的纤维结缔组织。 血管内细胞操作和炎症反应是从植入血管位置引起的。 生物相容性和生物可吸收性聚合物的血栓发生性由构成聚合物的成分的组成或比例控制。 生物相容性和生物吸收性聚合物是选自聚乙醇酸，聚乙醇酸/聚-L-乳酸共聚物，聚己内酯，聚羟基丁酸酯/羟基戊酸酯共聚物，聚-L-丙交酯中的至少一种聚合物。 聚二恶烷酮，聚碳酸酯和聚酐。

    Biodegradable polymer coils for intraluminal implants
    5.
    发明授权
    Biodegradable polymer coils for intraluminal implants 有权
    可生物降解的聚合物线圈用于腔内植入物

    公开(公告)号：US06423085B1

    公开(公告)日：2002-07-23

    申请号：US09406306

    申请日：1999-09-27

    申请人： Yuichi Murayama ,  Fernando Vinuela

    发明人： Yuichi Murayama ,  Fernando Vinuela

    IPC分类号： A61M2900

    CPC分类号： A61L31/16 ,  A61B17/12022 ,  A61B17/1215 ,  A61B17/12181 ,  A61B2017/00004 ,  A61B2017/1205 ,  A61L31/043 ,  A61L31/06 ,  A61L31/082 ,  A61L31/10 ,  A61L31/148 ,  A61L31/18 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/604 ,  C08L67/04

    摘要： An endovascular cellular manipulation and inflammatory response are elicited from implantation in a vascular compartment or any intraluminal location of a separable coil comprised at least in part of at least one biocompatible and absorbable polymer or protein and growth factors. Typically a catheter associated with the separable coil is used to dispose the coil into a selected body lumen. The biocompatible and absorbable polymer or protein is thrombogenic. The coil further is comprised at least in part of a growth factor or more particularly a vascular endothelial growth factor, a basic fibroblast growth factor or other growth factors. The biocompatible and absorbable polymer is in the illustrated embodiment at least one polymer selected from the group consisting of polyglycolic acid, poly˜glycolic acid poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide. Polydioxanone, polycarbonates, and polyanhydrides. The biocompatible and absorbable protein is at least one protein selected from the group consisting of collagen, fibrinogen, fibronectin, vitronectin, laminin, and gelatin. In one embodiment the coil is composed of the biocompatible and absorbable polymer or protein with a radio-opaque material is disposed thereon. Alternatively, the coil is composed of a radio-opaque material, and the biocompatible and absorbable polymer or protein is disposed thereon. This apparatus may be positioned within intracranial aneurysms or any aneurysm in the body as well as within other body cavities.

    摘要翻译： 血管内细胞操作和炎症反应是从至少部分由至少一种生物相容性和可吸收的聚合物或蛋白质和生长因子组成的可分离盘管的血管隔室或任何腔内位置植入引起的。 通常，与可分离线圈相关联的导管用于将线圈布置到选定的体腔中。 生物相容和可吸收的聚合物或蛋白质是血栓形成的。 线圈还包括至少部分生长因子，或更具体地包括血管内皮生长因子，碱性成纤维细胞生长因子或其他生长因子。 生物相容性和可吸收聚合物在所示实施方案中为至少一种选自聚乙醇酸，聚乙醇酸聚-L-乳酸共聚物，聚己内酯，聚羟基丁酸酯/羟基戊酸酯共聚物，聚-L-丙交酯的聚合物。 聚二恶烷酮，聚碳酸酯和聚酐。 生物相容性和可吸收蛋白质是选自胶原，纤维蛋白原，纤连蛋白，玻连蛋白，层粘连蛋白和明胶中的至少一种蛋白质。 在一个实施方案中，线圈由生物相容性和可吸收的聚合物或蛋白质组成，其上放置不透射线材料。 或者，线圈由不透射线材料构成，并且生物相容性和吸收性聚合物或蛋白质设置在其上。 该装置可以定位在颅内动脉瘤或体内以及其它体腔内的任何动脉瘤中。

    THIN FILM VASCULAR STENT AND BIOCOMPATIBLE SURFACE TREATMENT
    8.
    发明申请
    THIN FILM VASCULAR STENT AND BIOCOMPATIBLE SURFACE TREATMENT 有权
    薄膜血管和生物化学表面处理

    公开(公告)号：US20140249614A1

    公开(公告)日：2014-09-04

    申请号：US13224103

    申请日：2011-09-01

    申请人： Daniel S. Levi ,  Gregory P. Carman ,  Youngjae Chun ,  Fernando Vinuela

    发明人： Daniel S. Levi ,  Gregory P. Carman ,  Youngjae Chun ,  Fernando Vinuela

    IPC分类号： A61F2/07 ,  A61F2/95

    CPC分类号： A61F2/07 ,  A61B17/12022 ,  A61B17/12118 ,  A61B2017/1205 ,  A61F2/91 ,  A61F2/92 ,  A61F2/95 ,  A61F2002/077 ,  A61F2002/823 ,  A61L31/022 ,  A61L2400/18

    摘要： A vascular implant, comprising a sheet comprising thin film nickel titanium (NiTi), wherein the sheet has at least one super-hydrophilic surface having a water contact angle of less than approximately 5 degrees. The sheet is configured to have a compacted form having a first internal diameter and a deployed form having a second internal diameter larger than the first internal diameter. The sheet may be delivered into a blood vessel in the compacted form and expanded to its deployed form at a treatment location within the blood vessel, wherein the stent is configured to expand onto an internal surface of the blood vessel and exert a radial force on said internal surface.

    摘要翻译： 一种血管植入物，包括包含薄膜镍钛（NiTi）的片材，其中所述片材具有至少一个具有小于约5度的水接触角的超亲水表面。 片材被配置为具有第一内径的压实形式和具有大于第一内径的第二内径的展开形式。 片材可以以压缩形式递送到血管中并且在血管内的治疗位置处扩张到其展开形式，其中支架构造成扩张到血管的内表面上并在所述血管上施加径向力 内表面。