公开(公告)号：US06410914B1

公开(公告)日：2002-06-25

申请号：US09263659

申请日：1999-03-05

申请人： Melvin A. Park ,  Houle Wang ,  Frank Laukien

发明人： Melvin A. Park ,  Houle Wang ,  Frank Laukien

IPC分类号： H01J4904

CPC分类号： H01J49/107

摘要： The ionization chamber consists of a plurality of ports to accept multiple identical devices or varying devices. Ports may be arranged at various positions on the ionization chamber and at various angles with respect to the sampling orifice leading into the vacuum chamber of the mass spectrometer. A plurality of sprayers may operate in a time modulated manner and thereby the simultaneous multiplexed analysis of a multitude of samples is facilitated.

摘要翻译： 电离室由多个端口组成，以接受多个相同的装置或变化的装置。 端口可以​​布置在电离室上的各个位置处，并且相对于通向质谱仪的真空室的采样孔以各种角度排列。 多个喷雾器可以以时间调制方式操作，从而便于多个样品的同时多路复用分析。

公开(公告)号：US5739529A

公开(公告)日：1998-04-14

申请号：US783482

申请日：1997-01-14

申请人： Frank Laukien ,  Jurgen Grotemeyer ,  Johann Grundwurmer ,  Claus Koster

发明人： Frank Laukien ,  Jurgen Grotemeyer ,  Johann Grundwurmer ,  Claus Koster

IPC分类号： H01J49/40 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/405 ,  H01J49/065

摘要： In a time-of-flight mass spectrometer with an ion reflector located after the ion source and before the ion detector, to compensate for different starting energies of ions of equal masses, in the ion flight path inside or after the ion reflector at least one electrode is provided for, to which a pulsed high voltage is applied in such a way that within a predetermined narrow range of ion masses, time-of-flight errors for ions of equal masses due to different formation locations or times in the ion source are compensated for at the ion detector. In this way, apart from an energy compensation, also time-of-flight errors of the ions under investigation can simultaneously be compensated for.

摘要翻译： 在离子源位于离子检测器之后的离子反射器的飞行时间质谱仪中，为了补偿等质量的离子的不同起始能量，在离子反射器内部或之后的离子飞行路径中至少一个 提供电极，以这样的方式施加脉冲高压，使得在离子质量的预定窄范围内，由于离子源中的不同形成位置或次数而具有相等质量的离子的飞行时间误差为 在离子检测器处补偿。 这样，除了能量补偿之外，还可以同时补偿正在研究的离子的飞行时间误差。

公开(公告)号：US07315020B2

公开(公告)日：2008-01-01

申请号：US10178951

申请日：2002-06-24

申请人： Melvin A. Park ,  Houle Wang ,  Frank Laukien

发明人： Melvin A. Park ,  Houle Wang ,  Frank Laukien

IPC分类号： H01J49/10

CPC分类号： H01J49/107

摘要： The ionization chamber consists of a plurality of ports to accept multiple identical devices or varying devices. Ports may be arranged at various positions on the ionization chamber and at various angles with respect to the sampling orifice leading into the vacuum chamber of the mass spectrometer. A plurality of sprayers may operate in a time modulated manner and thereby the simultaneous multiplexed analysis of a multitude of samples is facilitated.

摘要翻译： 电离室由多个端口组成，以接受多个相同的装置或变化的装置。 端口可以​​布置在电离室上的各个位置处，并且相对于通向质谱仪的真空室的采样孔以各种角度排列。 多个喷雾器可以以时间调制方式操作，从而便于多个样品的同时多路复用分析。

公开(公告)号：US5505832A

公开(公告)日：1996-04-09

申请号：US432860

申请日：1995-05-02

申请人： Frank Laukien ,  Jochen Franzen

发明人： Frank Laukien ,  Jochen Franzen

IPC分类号： G01N27/447 ,  H01J49/04 ,  G01N27/26 ,  H01J49/10

CPC分类号： H01J49/0431 ,  G01N27/44717 ,  H01J49/167

摘要： The invention relates to a device and a method for mass-spectrometric analysis of substance samples which have been separated by capillary electrophoresis, particularly proteins, proteoglycanes or other protein conjugates, with ionization of the substance samples by a particularly substance-saving form of electrospraying. A method of "microspraying" is used which permits a flow of spray liquid of only several tens of nanoliters per minute in stable spray operation. The invention consists in a loose coupling of the spray capillary to the electrophoresis capillary in a liquid environment.

摘要翻译： 本发明涉及通过毛细管电泳分离的物质样品的质谱分析的装置和方法，特别是蛋白质，蛋白聚糖或其他蛋白质缀合物，通过特别物质节省形式的电喷雾离子化物质样品。 使用“微阵列”的方法，其允许在稳定的喷雾操作中每分钟流速为几十纳升的喷雾液体。 本发明包括在液体环境中将喷雾毛细管与电泳毛细管的松耦合。

公开(公告)号：US06670878B2

公开(公告)日：2003-12-30

申请号：US09953313

申请日：2001-09-17

申请人： Robert Schauwecker ,  Pierre-Alain Bovier ,  Daniel Eckert ,  Frank Laukien

发明人： Robert Schauwecker ,  Pierre-Alain Bovier ,  Daniel Eckert ,  Frank Laukien

IPC分类号： H01F500

CPC分类号： G01R33/3875 ,  G01R33/3815

摘要： A magnet arrangement comprising a superconducting magnet coil system (M) for producing a magnetic field in the direction of a z axis in a working volume (AV) disposed on the z axis about z=0, wherein the superconducting magnet coil system (M) comprises a radially inner partial coil system (C1) and a radially outer partial coil system (C2) which is coaxial thereto, and with a field forming device (P) of magnetic material disposed in a preferably cylindrically symmetrical fashion about the z axis, located radially between the radially inner and the radially outer partial coil system (C1, C2), and being coaxial with respect to the two partial coil systems (C1, C2), wherein the radially inner partial coil system (C1) produces a homogeneous field in the working volume (AV) and the radially outer partial coil system (C2) produces an inhomogeneous field in the working volume (AV) is characterized in that the radially outer partial coil system (C2) produces, together with the magnetic field forming device (P), a homogeneous field in the working volume (AV), wherein the magnetic material of the field forming device (P) is largely magnetically saturated with its magnetization pointing substantially in a direction along the z axis. In this fashion, a homogenized radially inner partial coil system (C1) can be supplemented with an inhomogeneous radially outer partial coil system (C2), such that, through the use of a magnetic field forming device (P), the overall resulting magnet arrangement once more produces a homogeneous magnetic field in the working volume of the magnet arrangement.

公开(公告)号：US5689187A

公开(公告)日：1997-11-18

申请号：US616961

申请日：1996-03-15

申请人： Daniel Marek ,  Frank Laukien ,  Oskar Schett

发明人： Daniel Marek ,  Frank Laukien ,  Oskar Schett

IPC分类号： G01R33/34 ,  G01V3/00

CPC分类号： G01R33/34069 ,  G01R33/34 ,  G01R33/3403 ,  G01R33/3635 ,  G01R33/365 ,  G01R33/56536 ,  G01R33/34023 ,  G01R33/34092

摘要： An RF receiver coil configuration for NMR spectrometers has at least two largely mutually orthogonal RF receiver coil systems of which at least one is made from superconducting material and is at least partially cooled to a cryogenic temperature lying far below room temperature, with each RF receiver coil system comprising at least one single coil arranged symmetrically about a sample the RF receiver coil systems having differing radial separations from the sample. The inner RF receiver coil system is made from a material having differing physical characteristics in dependence on the actual operating temperature than the material of the outer RF receiver coil system, with the materials and the geometries of the RF receiver coil systems being chosen to minimize the influence of the susceptibility of the RF receiver coil system on the homogeneity of the magnetic field in the vicinity of the sample. In this fashion, the high Q values of the resonator configuration achieved by the use of superconducting material with high electrical RF conductivity can be taken advantage of while, at the same time, avoiding the substantial interfering influences of the high susceptibility of the superconducting material.

摘要翻译： 用于NMR光谱仪的RF接收器线圈配置具有至少两个大的相互正交的RF接收器线圈系统，其中至少一个由超导材料制成，并且至少部分地被冷却到远低于室温的低温温度，每个RF接收器线圈 系统包括至少一个围绕样本对称布置的单个线圈，RF接收器线圈系统具有与样本不同的径向间隔。 内部RF接收器线圈系统由具有与外部RF接收器线圈系统的材料相比的实际工作温度具有不同物理特性的材料制成，其中RF接收器线圈系统的材料和几何形状被选择为使 RF接收器线圈系统的磁敏度对样品附近的磁场的均匀性的影响。 以这种方式，可以利用通过使用具有高RF导电性的超导材料实现的谐振器配置的高Q值，同时避免了超导材料的高磁化率的实质性干扰影响。