公开(公告)号：US20230402272A1

公开(公告)日：2023-12-14

申请号：US18032251

申请日：2021-09-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Eric Thomas Dziekonski

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42 ,  H01J49/40

CPC classification number: H01J49/009 ,  H01J49/061 ,  H01J49/063 ,  H01J49/4245 ,  H01J49/405 ,  H01J49/408

Abstract: Systems and methods are disclosed for ion injection into an electrostatic trap. Various aspects of this disclosure provide a mass spectrometer system including a primary ion path including a plurality of quadrupoles; and a secondary ion path coupled to the primary ion path utilizing turning elements. The secondary ion path may include an electrostatic linear ion trap (ELIT), the ELIT being operable to analyze ions diverted from the primary ion path and return them to the primary ion path. The primary ion path may include a time-of-flight mass analyzer. The secondary ion path may be bi-directional. Ions may travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and may travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path. The secondary ion path may include a collision quadrupole.

公开(公告)号：US11756782B2

公开(公告)日：2023-09-12

申请号：US17586421

申请日：2022-01-27

Applicant: Micromass UK Limited

Inventor： Anatoly Verenchikov ,  Mikhail Yavor

IPC: H01J49/40

CPC classification number: H01J49/406 ,  H01J49/405

Abstract: Improved ion mirrors 30 (FIG. 3) are proposed for multi-reflecting TOF MS and electrostatic traps. Minor and controlled variation by means of arranging a localized wedge field structure 35 at the ion retarding region was found to produce major tilt of ion packets time fronts 39. Combining wedge reflecting fields with compensated deflectors is proposed for electrically controlled compensation of local and global misalignments, for improved ion injection and for reversing ion motion in the drift direction. Fine ion optical properties of methods and embodiments are verified in ion optical simulations.

公开(公告)号：US20180330936A1

公开(公告)日：2018-11-15

申请号：US15776585

申请日：2016-11-16

Applicant: MICROMASS UK LIMITED ,  LECO CORPORATION

Inventor： John Brian Hoyes ,  Anatoly Verenchikov ,  Mikhail Yavor ,  Keith Richardson ,  Jason Wildgoose

IPC: H01J49/40 ,  H01J49/10 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/405 ,  H01J49/0004 ,  H01J49/062 ,  H01J49/067 ,  H01J49/10 ,  H01J49/406

Abstract: A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.

公开(公告)号：US09728391B2

公开(公告)日：2017-08-08

申请号：US14401683

申请日：2013-05-16

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/401 ,  G01N2223/506 ,  H01J49/0031 ,  H01J49/405 ,  H01J49/406 ,  H01J49/408

Abstract: A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.

公开(公告)号：US09564307B2

公开(公告)日：2017-02-07

申请号：US14945305

申请日：2015-11-18

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. Makarov

IPC: H01J49/40 ,  H01J49/42

CPC classification number: H01J49/405 ,  H01J49/4245 ,  H01J49/425 ,  H01J49/427

Abstract: A charged particle analyzer apparatus comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner, whereby when the electrode systems are electrically biased the mirrors create an electrical field comprising opposing electrical fields along z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces. A mass spectrometer system comprising a plurality of the charged particle analyzers arranged as a parallel array.

Abstract translation: 一种带电粒子分析仪装置，包括两个相对的离子镜，每个反射镜包括沿着轴线z延伸的内部和外部场限定电极系统，外部系统围绕内部，由此当电极系统被电偏置时，反射镜产生电场，包括相对 z电场; 以及至少一个弧形聚焦透镜，用于约束分束器内的带电粒子束的弓形发散，同时光束围绕轴线z运动，分析器还包括具有至少部分跨越内外两者之间的空间的两个面的圆盘 场定义电极系统并且位于垂直于轴线z的平面中，该盘在两个面上具有电阻涂层。 一种质谱仪系统，包括多个被布置成平行阵列的带电粒子分析器。

公开(公告)号：US20160365233A1

公开(公告)日：2016-12-15

申请号：US15155034

申请日：2016-05-15

Applicant: PERKINELMER HEALTH SCIENCES, INC.

Inventor： Anthony Chiappetta ,  Urs Steiner ,  Keith Ferrara

IPC: H01J49/06 ,  H01J49/40

CPC classification number: H01J49/067 ,  H01J49/405

Abstract: Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.

公开(公告)号：US09384954B2

公开(公告)日：2016-07-05

申请号：US14291417

申请日：2014-05-30

Applicant: Anthony Chiappetta ,  Urs Steiner ,  Keith Ferrara

Inventor： Anthony Chiappetta ,  Urs Steiner ,  Keith Ferrara

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/24

CPC classification number: H01J49/405 ,  H01J49/02 ,  H01J49/24 ,  H01J49/40

Abstract: Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.

Abstract translation: 本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。 在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

公开(公告)号：US09196469B2

公开(公告)日：2015-11-24

申请号：US13989697

申请日：2011-11-24

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/34 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/405 ,  H01J49/4245 ,  H01J49/425 ,  H01J49/427

Abstract: A method of selecting ions of interest from a beam of ions using an analyzer, the method comprising: (i) providing an analyzer comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii) causing the beam of ions to fly through the analyzer along a main flight path in the presence of an analyzer field so as to undergo within the analyzer at least one full oscillation in the direction of the analyzer axis while orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii) providing one or more sets of electrodes adjacent the main flight path; (iv) constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v) ejecting the ions of interest from the analyzer. Also provided is a charged particle analyzer comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyzer axis z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces.

公开(公告)号：US20150294849A1

公开(公告)日：2015-10-15

申请号：US14748582

申请日：2015-06-24

Applicant: Alexander A. MAKAROV ,  Dmitry E. GRINFELD ,  Mikhail A. MONASTYRSKIY

Inventor： Alexander A. MAKAROV ,  Dmitry E. GRINFELD ,  Mikhail A. MONASTYRSKIY

IPC: H01J49/40 ,  H01J49/06

CPC classification number: H01J49/406 ,  H01J49/061 ,  H01J49/405

Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.

Abstract translation: 公开了一种在多反射飞行时间质谱仪中反射离子的方法。 该方法包括将离子导向具有多个电极的离子反射镜，并向离子镜电极施加电压以产生电场，使得离子的平均轨迹与离子反射镜的对称平面相交并离开离子 反射镜，其中离子由反射镜在空间上聚焦到第一位置并且在时间上聚焦到与第一位置不同的第二位置。 还公开了用于执行该方法的装置。

公开(公告)号：US20150270115A1

公开(公告)日：2015-09-24

申请号：US14434596

申请日：2013-09-18

Applicant: Shimadzu Corporation

Inventor： Osamu Furuhashi

IPC: H01J49/40

CPC classification number: H01J49/405

Abstract: In an ion reflector (4) configured from a plurality of electrodes, electrodes 42 disposed in a second stage region (S2) for reflecting ions after deceleration are formed thinner than electrodes (41) disposed in a first stage region (S1) for decelerating the ions.The thin electrodes suppress unevenness of potential, in particular, in a path away from the center axis of the reflector, which results in improvement of isochronism of an ion packet passing on the path. The thick electrodes (41, 43) disposed in the first stage region (S1) prevents stretching of the grid electrodes (G1, G2) from being affected, and unevenness of potential in the first stage region (S1) hardly affects isochronism of the ions. By appropriately adjusting thicknesses and a pitch of the electrodes (41, 42, 43, 44) adjacent to one another so as to align intervals between the electrodes (41, 42, 43, 44), it is possible to use spacers having the same size in common. Since the number of electrodes in the first stage region (S1) can be reduced, an increase in costs is suppressed. Consequently, it is possible to bring an electric field of an ion reflection region closer to an ideal state and improve mass-resolving power while suppressing costs.

Abstract translation: 在由多个电极构成的离子反射体（4）中，比设置在第一阶段区域（S1）中的电极（41）更薄地设置在第二阶段区域（S2）中用于反射减速后的离子的电极42， 离子。 薄电极抑制电位的不均匀性，特别是在远离反射器的中心轴的路径中，这导致通过路径的离子包的等时性的改善。 设置在第一级区域（S1）中的厚电极（41,43）防止栅电极（G1，G2）的拉伸受到影响，第一级区域（S1）的电位不均匀性几乎不影响离子的等时性 。 通过适当地调整彼此相邻的电极（41,42,43,44）的厚度和间距以便对准电极（41,42,43,44）之间的间隔，可以使用具有相同的间隔物 大小相同 由于可以减少第一级区域（S1）中的电极的数量，因此抑制了成本的增加。 因此，可以使离子反射区域的电场更接近理想状态，并且能够在抑制成本的同时提高质量分辨能力。