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公开(公告)号：US20150368307A1
公开(公告)日：2015-12-24
申请号：US14799633
申请日：2015-07-15
IPC分类号： C07K14/445 , C12N15/86
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N15/867 , C12N2740/15023 , C12N2740/15043 , C12N2740/16023 , C12N2740/16043 , C12N2810/6081 , Y02A50/412
摘要： The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
摘要翻译： 本发明涉及用确定的异源病毒包膜蛋白或源自RNA病毒的病毒包膜蛋白假型包装的慢病毒载体颗粒，并且在其基因组中包含至少一个重组多核苷酸，所述重组多核苷酸编码至少一个携带表位的多肽 能够感染哺乳动物宿主的疟原虫寄生虫的抗原。 使用慢病毒载体颗粒以引发针对疟疾寄生虫的免疫应答。
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公开(公告)号：US08420104B2
公开(公告)日：2013-04-16
申请号：US12671898
申请日：2008-08-01
IPC分类号： A61K39/12 , A61K39/21 , A61K39/205 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/505 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C07K16/10 , C07K16/1054 , C07K16/1081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N15/86 , C12N2740/15022 , C12N2740/15034 , C12N2740/15043 , C12N2740/16222 , C12N2760/20222 , C12N2770/24122 , C12N2770/24134 , C12N2810/6081 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique administration or, for iterative administration in a host, and to their medicinal application (such as vaccination against Immunodeficiency Virus, especially suitable in human hosts). Gene transfer vectors are either integrative or non-integrative (NI) vectors, dependently upon the purpose of their use. The invention relates to the use of gene transfer vectors for unique or for multiple in vivo administration into a host in need thereof. The field of application of the present application concerns in particular animal treatment or treatment of human being (e.g. prophylactic or therapeutic or symptomatic or curative treatment), gene therapy or vaccination in vivo. These vectors may be used to elicit an immune response to prevent or to treat a pathogenic state, including virus infections (for example treatment or prevention against Immunodeficiency Virus and especially against AIDS), parasite and bacterial infections or cancers, and preferably to elicit a protective, long-lasting immune response.
摘要翻译： 本发明涉及基因转移载体的设计，特别是提供适合独特施用的慢病毒基因转移载体，或用于宿主中的迭代给药及其药物应用（例如针对免疫缺陷病毒的疫苗接种，特别适用于人 主机）。 基因转移载体是整合或非整合（NI）载体，依赖于其使用目的。 本发明涉及将基因转移载体用于独特或多次体内施用于有需要的宿主中。 本申请的应用领域特别涉及人的动物治疗或治疗（例如预防或治疗或症状或治疗性治疗），基因治疗或体内疫苗接种。 这些载体可用于引发免疫应答以预防或治疗包括病毒感染（例如治疗或预防免疫缺陷病毒，特别是针对艾滋病），寄生虫和细菌感染或癌症的致病状态，并且优选地引发保护性 ，持久的免疫反应。
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公开(公告)号：US09822153B2
公开(公告)日：2017-11-21
申请号：US14799633
申请日：2015-07-15
IPC分类号： C12N15/867 , C07K14/445 , A61K39/015 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N15/867 , C12N2740/15023 , C12N2740/15043 , C12N2740/16023 , C12N2740/16043 , C12N2810/6081 , Y02A50/412
摘要： The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
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公开(公告)号：US20130171195A1
公开(公告)日：2013-07-04
申请号：US13695683
申请日：2011-04-29
IPC分类号： C12N15/867
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N15/867 , C12N2740/15023 , C12N2740/15043 , C12N2740/16023 , C12N2740/16043 , C12N2810/6081 , Y02A50/412
摘要： The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
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公开(公告)号：US09109234B2
公开(公告)日：2015-08-18
申请号：US13695683
申请日：2011-04-29
IPC分类号： C12N15/867 , A61K39/015 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N15/867 , C12N2740/15023 , C12N2740/15043 , C12N2740/16023 , C12N2740/16043 , C12N2810/6081 , Y02A50/412
摘要： The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
摘要翻译： 本发明涉及用确定的异源病毒包膜蛋白或源自RNA病毒的病毒包膜蛋白假型包装的慢病毒载体颗粒，并且在其基因组中包含至少一个重组多核苷酸，所述重组多核苷酸编码至少一个携带表位的多肽 能够感染哺乳动物宿主的疟原虫寄生虫的抗原。 使用慢病毒载体颗粒以引发针对疟疾寄生虫的免疫应答。
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公开(公告)号：US08709799B2
公开(公告)日：2014-04-29
申请号：US13453784
申请日：2012-04-23
IPC分类号： C12N15/00 , A61K39/205 , A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/505 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C07K16/10 , C07K16/1054 , C07K16/1081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N15/86 , C12N2740/15022 , C12N2740/15034 , C12N2740/15043 , C12N2740/16222 , C12N2760/20222 , C12N2770/24122 , C12N2770/24134 , C12N2810/6081 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique administration or for iterative administration in a host, and to their medicinal application (such as vaccination against Immunodeficiency Virus, especially suitable in human hosts). Gene transfer vectors can be either integrative or non-integrative vectors. The invention encompasses prophylactic, therapeutic, symptomatic, and curative treatments of animals, including humans, as well as gene therapy and vaccination in vivo.
摘要翻译： 本发明涉及基因转移载体的设计，特别是提供适用于宿主中独特施用或迭代施用的慢病毒基因转移载体及其药物应用（例如针对免疫缺陷病毒的疫苗接种，特别适用于人宿主 ）。 基因转移载体可以是整合或非整合载体。 本发明包括对动物（包括人）的预防，治疗，症状和治疗性治疗，以及基因治疗和体内疫苗接种。
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公开(公告)号：US20120315296A1
公开(公告)日：2012-12-13
申请号：US13453784
申请日：2012-04-23
IPC分类号： A61K31/7088 , A61P31/18 , C12N15/86
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/505 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C07K16/10 , C07K16/1054 , C07K16/1081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N15/86 , C12N2740/15022 , C12N2740/15034 , C12N2740/15043 , C12N2740/16222 , C12N2760/20222 , C12N2770/24122 , C12N2770/24134 , C12N2810/6081 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique administration or for iterative administration in a host, and to their medicinal application (such as vaccination against Immunodeficiency Virus, especially suitable in human hosts). Gene transfer vectors can be either integrative or non-integrative vectors. The invention encompasses prophylactic, therapeutic, symptomatic, and curative treatments of animals, including humans, as well as gene therapy and vaccination in vivo.
摘要翻译： 本发明涉及基因转移载体的设计，特别是提供适用于宿主中独特施用或迭代施用的慢病毒基因转移载体及其药物应用（例如针对免疫缺陷病毒的疫苗接种，特别适用于人宿主 ）。 基因转移载体可以是整合或非整合载体。 本发明包括对动物（包括人）的预防，治疗，症状和治疗性治疗，以及基因治疗和体内接种。
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公开(公告)号：US20100297168A1
公开(公告)日：2010-11-25
申请号：US12671898
申请日：2008-08-01
IPC分类号： A61K39/145 , A61P31/16 , A61P31/18
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/505 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C07K16/10 , C07K16/1054 , C07K16/1081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N15/86 , C12N2740/15022 , C12N2740/15034 , C12N2740/15043 , C12N2740/16222 , C12N2760/20222 , C12N2770/24122 , C12N2770/24134 , C12N2810/6081 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique administration or, for iterative administration in a host, and to their medicinal application (such as vaccination against Immunodeficiency Virus, especially suitable in human hosts). Gene transfer vectors are either integrative or non-integrative (NI) vectors, dependently upon the purpose of their use. The invention relates to the use of gene transfer vectors for unique or for multiple in vivo administration into a host in need thereof. The field of application of the present application concerns in particular animal treatment or treatment of human being (e.g. prophylactic or therapeutic or symptomatic or curative treatment), gene therapy or vaccination in vivo. These vectors may be used to elicit an immune response to prevent or to treat a pathogenic state, including virus infections (for example treatment or prevention against Immunodeficiency Virus and especially against AIDS), parasite and bacterial infections or cancers, and preferably to elicit a protective, long-lasting immune response.
摘要翻译： 本发明涉及基因转移载体的设计，特别是提供适用于独特施用的慢病毒基因转移载体，或用于宿主中的迭代施用及其药物应用（例如针对免疫缺陷病毒的疫苗接种，特别适用于人 主机）。 基因转移载体是整合或非整合（NI）载体，依赖于其使用目的。 本发明涉及将基因转移载体用于独特或多次体内施用于有需要的宿主中。 本申请的应用领域特别涉及人的动物治疗或治疗（例如预防或治疗或症状或治疗性治疗），基因治疗或体内疫苗接种。 这些载体可用于引发免疫应答以预防或治疗包括病毒感染（例如治疗或预防免疫缺陷病毒，特别是针对艾滋病），寄生虫和细菌感染或癌症的致病状态，并且优选地引发保护性 ，持久的免疫反应。
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