公开(公告)号：US07671234B2

公开(公告)日：2010-03-02

申请号：US11913597

申请日：2006-05-02

申请人： Alfred Oftring ,  Gerold Braun ,  Friedrich Wirsing ,  Armin Stamm ,  Kai-Uwe Baldenius

发明人： Alfred Oftring ,  Gerold Braun ,  Friedrich Wirsing ,  Armin Stamm ,  Kai-Uwe Baldenius

IPC分类号： C07C227/26 ,  C07C229/16

CPC分类号： C07C227/26 ,  C07C229/16

摘要： The invention relates to a process for preparing low-by-product, light-color methylglycine-N,N-diacetic acid tri(alkali metal) salt by alkaline hydrolysis of methylglycinediacetonitrile (MGDN), comprising the steps in the sequence (a) to (f): (a) mixing of MGDN with aqueous alkali at a temperature of ≦30° C.; (b) allowing the aqueous alkaline MGDN suspension to react at a temperature in the range from 10 to 30° C. over a period of from 0.1 to 10 h to form a solution; (c) allowing the solution from step (b) to react at a temperature in the range from 30 to 40° C. over a period of from 0.1 to 10 h; (d) optionally allowing the solution from step (c) to react at a temperature in the range from 50 to 80° C. over a period of from 0.5 to 2 h; (e) optionally allowing the solution from step (c) or (d) to react at a temperature in the range from 110 to 200° C. over a period of from 5 to 60 min; (f) hydrolysis and removal of ammonia of the solution obtained in step (c), (d) or (e) by stripping at a temperature of from 90 to 105° C.

摘要翻译： 本发明涉及通过甲基甘氨二乙腈（MGDN）的碱水解制备低副产物，浅色甲基甘氨酸-N，N-二乙酸三（碱金属）盐的方法，包括步骤（a）至 （f）：（a）在温度为30℃的温度下，将MGDN与碱水溶液混合; （b）使含水碱性MGDN悬浮液在10至30℃的温度下反应0.1至10小时以形成溶液; （c）允许来自步骤（b）的溶液在0.1至10小时的时间内在30至40℃的温度下反应; （d）任选地允许步骤（c）的溶液在0.5至2小时的时间内在50至80℃的温度下反应; （e）任选地允许来自步骤（c）或（d）的溶液在110至200℃的温度下在5至60分钟的时间内反应; （f）通过在90至105℃的温度下汽提来水解和除去在步骤（c），（d）或（e）中获得的溶液中的氨。

公开(公告)号：US20080194873A1

公开(公告)日：2008-08-14

申请号：US11913597

申请日：2006-05-02

申请人： Alfred Oftring ,  Gerold Braun ,  Friedrich Wirsing ,  Armin Stamm ,  Kai-Uwe Baldenius

发明人： Alfred Oftring ,  Gerold Braun ,  Friedrich Wirsing ,  Armin Stamm ,  Kai-Uwe Baldenius

IPC分类号： C07C229/24

CPC分类号： C07C227/26 ,  C07C229/16

摘要： The invention relates to a process for preparing low-by-product, light-color methylglycine-N,N-diacetic acid tri(alkali metal) salt by alkaline hydrolysis of methylglycinediacetonitrile (MGDN), comprising the steps in the sequence (a) to (f): (a) mixing of MGDN with aqueous alkali at a temperature of ≦30° C.; (b) allowing the aqueous alkaline MGDN suspension to react at a temperature in the range from 10 to 30° C. over a period of from 0.1 to 10 h to form a solution; (c) allowing the solution from step (b) to react at a temperature in the range from 30 to 40° C. over a period of from 0.1 to 10 h; (d) optionally allowing the solution from step (c) to react at a temperature in the range from 50 to 80° C. over a period of from 0.5 to 2 h; (e) optionally allowing the solution from step (c) or (d) to react at a temperature in the range from 110 to 200° C. over a period of from 5 to 60 min; (f) hydrolysis and removal of ammonia of the solution obtained in step (c), (d) or (e) by stripping at a temperature of from 90 to 105° C.

摘要翻译： 本发明涉及通过甲基甘氨二乙腈（MGDN）的碱水解制备低副产物，浅色甲基甘氨酸-N，N-二乙酸三（碱金属）盐的方法，包括步骤（a）至 （f）：（a）在<= 30℃的温度下将MGDN与碱水溶液混合; （b）使含水碱性MGDN悬浮液在10至30℃的温度下反应0.1至10小时以形成溶液; （c）允许来自步骤（b）的溶液在0.1至10小时的时间内在30至40℃的温度下反应; （d）任选地允许步骤（c）的溶液在0.5至2小时的时间内在50至80℃的温度下反应; （e）任选地允许来自步骤（c）或（d）的溶液在110至200℃的温度下在5至60分钟的时间内反应; （f）通过在90至105℃的温度下汽提来水解和除去在步骤（c），（d）或（e）中获得的溶液中的氨。

公开(公告)号：US06509012B1

公开(公告)日：2003-01-21

申请号：US09403638

申请日：1999-10-25

申请人： Peter Hössel ,  Michael Zirnstein ,  Walter Schunter ,  Friedrich Wirsing ,  Wolfgang Kasel ,  Knut Oppenländer

发明人： Peter Hössel ,  Michael Zirnstein ,  Walter Schunter ,  Friedrich Wirsing ,  Wolfgang Kasel ,  Knut Oppenländer

IPC分类号： A61K708

CPC分类号： A61Q5/00 ,  A61K8/416 ,  A61K2800/526 ,  A61K2800/59

摘要： The disclosure sets forth aqueous cationic surfactant formulations and a process for their preparation. The formulations contains in solution a) from 10 to 50% by weight of a quaternary ammonium compound of the formula I: where: the substituents have the meanings set forth in the description, and b) from 0.01 to 15% by weight of an amine of the formula III: and c) from 0.1 to 5.0% by weight of a buffer which maintains a pH in a range from 4 to 9. The surfactant formulation is prepared by reacting an amine of the formula III in aqueous solution with a dialkyl sulfate of the formula IV where R1 to R5 are in a molar ratio range from 85 to 99.99 mol %, based on the amine and at from 20 to 100 degrees C. and then adding to the reaction solution from 0.1 to 5.0% by weight of a buffer which maintains a pH in a range from 4 to 9.

摘要翻译： 本公开提出了阳离子表面活性剂水溶液及其制备方法。 所述制剂在溶液中含有10至50重量％的式I季铵化合物：其中：取代基具有说明书中所述的含义，和b）0.01至15重量％的胺 的式III：和c）0.1至5.0重量％的保持pH在4至9范围内的缓冲液。表面活性剂制剂通过使式IIIin水溶液中的胺与硫酸二烷基酯 式IV其中R 1至R 5的摩尔比为85至99.99mol％，基于胺，并且在20至100℃下，然后向反应溶液中加入0.1至5.0重量％的缓冲液， 保持pH在4至9的范围内。

公开(公告)号：US08455682B2

公开(公告)日：2013-06-04

申请号：US12919149

申请日：2009-03-02

申请人： Alfred Oftring ,  Armin Stamm ,  Friedrich Wirsing ,  Gerold Braun

发明人： Alfred Oftring ,  Armin Stamm ,  Friedrich Wirsing ,  Gerold Braun

IPC分类号： C07C229/16

CPC分类号： C07C227/18 ,  C07C229/24

摘要： Provided is a method for the production of aminodicarboxylic acid N,N-diacetic acids of formula (I), wherein X is independently hydrogen or an alkali metal and n is 1 or 2. Aminodicarboxylic acid-N,N-diacetic acids of high purity can be yielded. The method involves: a) reacting an aminodicarboxylic acid, with 0.8 to 1.2 mole equivalents of formaldehyde and with 0.8 to 1.2 mole equivalents of hydrocyanic acid; b) reacting the reaction products of a) with 0.8 to 1.2 mole equivalents of hydrocyanic acid and with 0.8 to 1.2 mole equivalents of formaldehyde; c) hydrolyzing in the reaction product obtained in b).

摘要翻译： 提供了制备式（I）的氨基二羧酸N，N-二乙酸的方法，其中X独立地是氢或碱金属，n是1或2.高纯度的氨基二羧酸-N，N-二乙酸 可以得到。 该方法包括：a）使氨基二羧酸与0.8至1.2摩尔当量的甲醛和0.8至1.2摩尔当量的氢氰酸反应; b）使a）的反应产物与0.8至1.2摩尔当量的氢氰酸和0.8至1.2摩尔当量的甲醛反应; c）在b）中得到的反应产物中水解。

公开(公告)号：US06861548B2

公开(公告)日：2005-03-01

申请号：US10236904

申请日：2002-09-09

申请人： Thomas Greindl ,  Gerold Braun ,  Friedrich Wirsing ,  Georg Krug

发明人： Thomas Greindl ,  Gerold Braun ,  Friedrich Wirsing ,  Georg Krug

IPC分类号： C07C253/00 ,  C07C255/04 ,  C07C255/05 ,  C07C253/22

CPC分类号： C07C253/00 ,  Y02P20/582 ,  C07C255/04 ,  C07C255/05

摘要： The invention relates to a continuous process, carried out in two steps, for the cyanoalkylation of compounds having one or more NH functions by reaction thereof with carbonyl compounds and hydrocyanic acid, in which the first step is carried out without pressure at a temperature which is below the boiling point of the reaction mixture.

摘要翻译： 本发明涉及通过与羰基化合物和氢氰酸反应使其具有一个或多个NH官能团的化合物的氰基烷基化进行两步的连续方法，其中第一步在没有压力的情况下在温度为 低于反应混合物的沸点。

公开(公告)号：US20110004016A1

公开(公告)日：2011-01-06

申请号：US12919149

申请日：2009-03-02

申请人： Alfred Oftring ,  Armin Stamm ,  Friedrich Wirsing ,  Gerold Braun

发明人： Alfred Oftring ,  Armin Stamm ,  Friedrich Wirsing ,  Gerold Braun

IPC分类号： C07C227/18 ,  C07C229/24

CPC分类号： C07C227/18 ,  C07C229/24

摘要： The present invention relates to a method for the production of aminodicarboxylic acid-N,N,diacetic acids of the general Formula I, wherein X independently of one another represents hydrogen or an alkali metal and n represents a number 1 or 2. Furthermore, the invention relates to aminodicarboxylic acid-N,N-diacetic acids of high purity. The inventive method comprises the following steps: A.) reacting an aminodicarboxylic acid of the general Formula II, wherein X and n have the aforementioned meanings, with 0.8 to 1.2 mole equivalents of formaldehyde and with 0.8 to 1.2 mole equivalents of hydrocyanic acid; b) reacting the reaction products of step a) with 0.8 to 1.2 mole equivalents of hydrocyanic acid and with 0.8 to 1.2 mole equivalents of formaldehyde; c) hydrolyzing in the reaction product obtained in step b).

摘要翻译： 本发明涉及一种制备通式I的氨基二羧酸-N，N-二乙酸的方法，其中X彼此独立地表示氢或碱金属，n表示数1或2.此外， 本发明涉及高纯度的氨基二羧酸-N，N-二乙酸。 本发明方法包括以下步骤：A.将具有上述含义的X和n的通式II的氨基二羧酸与0.8至1.2摩尔当量的甲醛和0.8至1.2摩尔当量的氢氰酸反应; b）使步骤a）的反应产物与0.8至1.2摩尔当量的氢氰酸和0.8至1.2摩尔当量的甲醛反应; c）在步骤b）中获得的反应产物中水解。

公开(公告)号：US5210187A

公开(公告)日：1993-05-11

申请号：US865744

申请日：1992-04-09

申请人： Manfred Patsch ,  Uwe Nahr ,  Friedrich Wirsing ,  Joerg L. Jessen ,  Klaus Pandl ,  Claus Marschner ,  Matthias Dust

发明人： Manfred Patsch ,  Uwe Nahr ,  Friedrich Wirsing ,  Joerg L. Jessen ,  Klaus Pandl ,  Claus Marschner ,  Matthias Dust

IPC分类号： C07C317/14 ,  C07C317/32 ,  C09B62/02 ,  C09B62/44 ,  C09B62/503

CPC分类号： C09B62/4403 ,  C07C317/14 ,  C07C317/32 ,  C09B62/02 ,  C09B62/503

摘要： Double attachment reactive dyes have the formula ##STR1## where U.sup.1 is C.sub.1 -C.sub.4 -alkyl, phenyl, C.sub.2 -C.sub.10 -alkenyl or the radical ##STR2## where Q.sup.1 and Q.sup.2 are each independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl and Q.sup.3 is a group which is detachable under alkaline reaction conditions,Z is the radical ##STR3## where each Q.sup.4 is independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl which may be substituted by cyano, U.sup.2 is C.sub.1 -C.sub.4 -alkyl, phenyl, C.sub.2 -C.sub.10 -alkenyl or the radical ##STR4## where Q.sup.5 and Q.sup.6 are each independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl and Q.sup.7 is a group which is detachable under alkaline reaction conditions, and w is 0, 1 or 2,t is 0, 1 or 2,v is 1 or 2 and X and L are each as defined in the description, with the proviso that at least one of the two radicals U.sup.1 and U.sup.2 is not C.sub.1 -C.sub.4 -alkyl or phenyl, and are prepared from benzyl compounds of the formula ##STR5## where A is nitro or amino and U.sup.1, Z and t are each as defined above. The reactive dyes are useful for dyeing hydroxyl-containing fibers such as cotton and wool and provide high yields and high wet fastness.

摘要翻译： 双连接活性染料具有式“IMAGE”，其中U1是C1-C4-烷基，苯基，C2-C10-烯基或基团，其中Q1和Q2各自独立地是氢或C1-C4-烷基， Q3是在碱性反应条件下可分离的基团，Z是基团，其中每个Q 4独立于可被氰基取代的另一个氢或C 1 -C 4 - 烷基，U 2是C 1 -C 4 - 烷基，苯基 ，C 2 -C 10 - 烯基或基团，其中Q 5和Q 6各自独立地为氢或C 1 -C 4 - 烷基，Q 7为在碱性反应条件下可分离的基团，w为0,1或2 ，t为0,1或2，v为1或2，X和L各自如说明书中所定义，条件是两个基团U1和U2中的至少一个不是C 1 -C 4 - 烷基或苯基， 并且由式为“IMAGE”的苄基化合物制备，其中A是硝基或氨基，并且U1，Z和t各自如上所定义。 活性染料可用于染色含有羟基的纤维如棉和羊毛，并提供高产率和高耐湿牢度。