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公开(公告)号:US20170281826A1
公开(公告)日:2017-10-05
申请号:US15622853
申请日:2017-06-14
申请人: Universitat Politecnica de Valencia , Fundacion Para la Investigacion Biomedica Del Hospital Clinico San Carlos
发明人: Manuel MONLEON PRADAS , Ana VALLES LLUCH , Cristina MARTINEZ RAMOS , Guillermo VILARINO FELTRER , Juan Antonio BARCIA ALBACAR , Ulises Alfonso GOMEZ PINEDO
IPC分类号: A61L27/20 , A61L27/56 , A61L27/52 , A61L27/38 , B29C67/20 , A61B17/11 , A61F2/04 , A61F2/00 , B29C45/72 , A61L27/58 , A61L27/54
CPC分类号: A61L27/20 , A61B17/1128 , A61B2017/00004 , A61B2017/00526 , A61B2017/00893 , A61F2/0077 , A61F2/02 , A61F2/04 , A61F2002/0086 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L27/383 , A61L27/3878 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2430/32 , B29C45/7207 , B29C67/20 , B29K2067/00 , B29K2827/18 , B29L2031/753 , C08L5/08
摘要: The invention relates to a biohybrid for the use thereof in the regeneration of neural tracts, comprising an implantable tubular hybrid structure which is degradable and biocompatible and characterized in that it comprises three layers of different porosity: an inner layer a), an intermediate layer b) and an outer layer c), with uninterrupted connection among them, the three layers consisting of the same porous hydrogel based on cross-linked hyaluronic acid, a biohybrid comprising the hybrid tubular structure described, which can contain a fibrous material, preferably poly-L-lactic acid, to a method for producing said tubular hybrid structure and said biohybrid, and to the use of same for regenerating neural tracts in diseases that affect the central nervous system, preferably Parkinson's disease.