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    MICROFLUIDIC CARTRIDGES FOR PROCESSING PARTICLES AND CELLS
    3.
    发明申请
    MICROFLUIDIC CARTRIDGES FOR PROCESSING PARTICLES AND CELLS 有权

    公开(公告)号：US20230028754A1

    公开(公告)日：2023-01-26

    申请号：US17788697

    申请日：2020-12-23

    申请人： GPB Scientific, Inc.

    发明人： Alison SKELLEY ,  Yasna BEHMARDI ,  Anthony WARD ,  Khushroo GANDHI

    IPC分类号： B01L3/00

    摘要： Described herein is a microfluidic cartridge for purifying target particles or target cells of a predetermined size from contaminants in a sample, the cartridge comprising a first and a second planar support the first and second planar support each having a top surface and a bottom surface, wherein the top surface of the first and/or second planar support comprises at least one embedded channel extending from one or more inlets to one or more outlets; the at least one embedded channel comprising a plurality of obstacles, wherein the microfluidic cartridge comprises at least one void space configured to be deformed when assembling the first and second planar supports into the microfluidic cartridge.

    SYSTEMS AND METHODS FOR PARTICLE SEPARATION AND CONCENTRATION
    7.
    发明公开
    SYSTEMS AND METHODS FOR PARTICLE SEPARATION AND CONCENTRATION 审中-公开

    公开(公告)号：US20240101944A1

    公开(公告)日：2024-03-28

    申请号：US18261748

    申请日：2022-01-20

    申请人： GPB Scientific, Inc.

    发明人： Alison SKELLEY ,  Khushroo GANDHI ,  Anthony WARD ,  Laura HEALEY ,  Roberto CAMPOS GONZALEZ ,  Laurissa OUAGUIA-PALUDAN ,  Yasna BEHMARDI

    IPC分类号： C12M3/00 ,  C12M1/00 ,  C12M1/02 ,  C12M1/36 ,  C12M3/06

    CPC分类号： C12M23/42 ,  C12M23/16 ,  C12M27/00 ,  C12M29/20 ,  C12M41/48 ,  C12M47/04

    摘要： Described herein are systems and methods for generating a product enriched in one or more target particles, comprising a cassette to which the one or more microfluidic cartridges are releasably coupled and supported, the cassette comprising (i) a plurality input containers releasably and fluidically coupled thereto, wherein at least one of the plurality of input containers comprises an incoming sample, (ii) a plurality of outlets having a plurality of output containers releasably and fluidically coupled thereto, (iii) one or more microfluidic cartridges for separating one or more target particles from the sample, and (iv) a plurality of fluidic channels extending between the plurality of inlets, the plurality of outlets, and the one or more microfluidic cartridges, wherein the cassette having the plurality of input containers, the plurality of output containers, and the one or more microfluidic cartridges coupled thereto, collectively provides a closed end-to-end sterile environment that enables inline continuous processing of the incoming sample without external manual handling or intervention, so as to generate a product that is enriched in one or more target particles and free of contamination.