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公开(公告)号：US07709190B2
公开(公告)日：2010-05-04
申请号：US11566216
申请日：2006-12-02
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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公开(公告)号：US20080108050A1
公开(公告)日：2008-05-08
申请号：US11566216
申请日：2006-12-02
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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公开(公告)号：US20100247569A1
公开(公告)日：2010-09-30
申请号：US12706804
申请日：2010-02-17
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
IPC分类号： A61K39/145 , C12N7/04 , A61P31/16 , C07K14/00
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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公开(公告)号：US08455621B2
公开(公告)日：2013-06-04
申请号：US12706804
申请日：2010-02-17
申请人： Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
发明人： Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
IPC分类号： C07K1/00
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
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公开(公告)号：US07601490B2
公开(公告)日：2009-10-13
申请号：US11566214
申请日：2006-12-02
申请人： Robert M. Krug , Karen Y. Twu
发明人： Robert M. Krug , Karen Y. Twu
CPC分类号： C07K14/47 , A61K38/16 , A61K38/17 , A61K39/0008 , A61K2039/55516 , C07K14/005 , C07K14/705 , C12N5/0636 , C12N5/163 , C12N7/00 , C12N7/04 , C12N2760/16111 , C12N2760/16134 , Y10S514/888
摘要： The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 protein and the Influenza A NS1A protein is reduced.
摘要翻译： 本发明包括通过使抗病毒剂与CPSF30蛋白质的F2F3锌指和甲型流感A型NS1A蛋白接触来分离和表征新的抗病毒剂的组合物，方法和系统; 并确定CPSF30蛋白与A型流感NS1A蛋白之间的结合是否降低。
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公开(公告)号：US09499595B2
公开(公告)日：2016-11-22
申请号：US12554767
申请日：2009-09-04
申请人： Robert M. Krug , Karen Y. Twu
发明人： Robert M. Krug , Karen Y. Twu
IPC分类号： C07K14/47 , C07K14/705 , C07K14/005 , C12N7/04 , C12N7/00 , C12N5/16 , A61K39/00 , A61K38/17 , A61K38/16 , C12N5/0783
CPC分类号： C07K14/47 , A61K38/16 , A61K38/17 , A61K39/0008 , A61K2039/55516 , C07K14/005 , C07K14/705 , C12N5/0636 , C12N5/163 , C12N7/00 , C12N7/04 , C12N2760/16111 , C12N2760/16134 , Y10S514/888
摘要： The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 protein and the Influenza A NS1A protein is reduced.
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公开(公告)号：US20100107264A1
公开(公告)日：2010-04-29
申请号：US12554767
申请日：2009-09-04
申请人： Robert M. Krug , Karen Y. Twu
发明人： Robert M. Krug , Karen Y. Twu
CPC分类号： C07K14/47 , A61K38/16 , A61K38/17 , A61K39/0008 , A61K2039/55516 , C07K14/005 , C07K14/705 , C12N5/0636 , C12N5/163 , C12N7/00 , C12N7/04 , C12N2760/16111 , C12N2760/16134 , Y10S514/888
摘要： The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 protein and the Influenza A NS1A protein is reduced.
摘要翻译： 本发明包括通过使抗病毒剂与CPSF30蛋白质的F2F3锌指和甲型流感A型NS1A蛋白接触来分离和表征新的抗病毒剂的组合物，方法和系统; 并确定CPSF30蛋白与A型流感NS1A蛋白之间的结合是否降低。
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