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公开(公告)号：US20080146632A1
公开(公告)日：2008-06-19
申请号：US12024859
申请日：2008-02-01
Applicant: Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
Inventor： Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
IPC: A61K31/41 , C07D403/12 , C07C321/20 , A61K31/192 , C07D333/70 , A61K31/381 , C07C321/30 , A61P37/00 , A61P19/02
CPC classification number: C07C323/56 , C07C59/68 , C07C65/36 , C07C65/38 , C07C229/60 , C07C233/05 , C07C251/24 , C07C251/86 , C07C255/41 , C07C271/22 , C07C275/24 , C07C275/42 , C07C317/44 , C07C323/22 , C07C323/60 , C07C323/62 , C07C2603/18 , C07D207/333 , C07D249/14 , C07D277/20 , C07D303/38 , C07D333/70 , C07D409/14 , C07K5/06026 , C07K5/0806
Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Abstract translation: 本发明提供能够结合Fc受体并调节Fc受体活性的化合物，其包含被富含p电子的基团取代的芳基形式的核心亲油基团。 本发明还提供了使用这些化合物治疗涉及Fc受体活性的自身免疫性疾病的方法。 还提供了一种获得调节Fc受体活性的化合物的方法，所述方法包括：（a）提供或设计具有结构特征的化合物，以配合FcγRIIa结构的凹槽; 和（b）筛选化合物以调节对Fc受体的活性。
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公开(公告)号：US20100008951A1
公开(公告)日：2010-01-14
申请号：US12443048
申请日：2007-10-02
Applicant: Geoffrey Allan Pietersz , Sandra Elizabeth Esparon , Owen Proudfoot
Inventor： Geoffrey Allan Pietersz , Sandra Elizabeth Esparon , Owen Proudfoot
IPC: A61K39/145 , A61P31/16
CPC classification number: A61K31/715 , A61K39/0208 , A61K39/04 , A61K39/12 , A61K39/15 , A61K39/385 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/55583 , A61K2039/57 , A61K2039/6087 , C12N2710/20034 , C12N2720/12334 , Y02A50/412
Abstract: The present invention relates to a vaccine composition comprising a carbohydrate polymer comprising mannose and flu antigen(s) (e.g. whole inactivated influenza virus) in admixture, and a method of immunising a subject comprising the step of administering the vaccine composition to a subject.
Abstract translation: 本发明涉及一种包含含有甘露糖和流感抗原（例如全灭活流感病毒）的碳水化合物聚合物的混合物的疫苗组合物，以及免疫受试者的方法，所述方法包括向受试者施用疫苗组合物的步骤。
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公开(公告)号：US5798097A
公开(公告)日：1998-08-25
申请号：US420712
申请日：1995-04-11
Applicant: Ian Farquhar Campbell McKenzie , Geoffrey Allan Pietersz , Mark John Smyth
IPC: G01N33/53 , A61K20060101 , A61K31/704 , A61K39/395 , A61K39/44 , A61K47/48 , A61P35/00 , C07H15/252 , C07K1/16 , C07K14/00 , C07K16/00 , C07K16/28 , C07K16/44 , C12N20060101 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , C07K17/00
CPC classification number: A61K47/48407
Abstract: Immunoglobulin conjugates, comprising idarubicin (Ida) conjugated to a monoclonal antibody or fragment thereof comprising at least one of the antigen binding sites of the antigen, are useful for treating a human or other animal suffering from a cancer or for depleting a subset of T lymphocytes from a population of cells.
Abstract translation: 与包含抗原的抗原结合位点中的至少一个的单克隆抗体或其片段缀合的伊达比星（Ida）的免疫球蛋白缀合物可用于治疗患有癌症的人或其他动物或用于消耗T淋巴细胞亚群 从一群细胞。
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公开(公告)号：US08182821B2
公开(公告)日：2012-05-22
申请号：US12443048
申请日：2007-10-02
Applicant: Geoffrey Allan Pietersz , Sandra Elizabeth Esparon , Owen Proudfoot
Inventor： Geoffrey Allan Pietersz , Sandra Elizabeth Esparon , Owen Proudfoot
IPC: A61K39/145
CPC classification number: A61K31/715 , A61K39/0208 , A61K39/04 , A61K39/12 , A61K39/15 , A61K39/385 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/55583 , A61K2039/57 , A61K2039/6087 , C12N2710/20034 , C12N2720/12334 , Y02A50/412
Abstract: The present invention relates to a vaccine composition comprising a carbohydrate polymer comprising mannose and flu antigen(s) (e.g. whole inactivated influenza virus) in admixture, and a method of immunising a subject comprising the step of administering the vaccine composition to a subject.
Abstract translation: 本发明涉及一种包含含有甘露糖和流感抗原（例如全灭活流感病毒）的碳水化合物聚合物的混合物的疫苗组合物，以及免疫受试者的方法，所述方法包括向受试者施用疫苗组合物的步骤。
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Patent Agency Ranking
公开(公告)号：US07910770B2
公开(公告)日：2011-03-22
申请号：US12024859
申请日：2008-02-01
Applicant: Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
Inventor： Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
IPC: C07D409/12 , C07D333/70 , C07D277/36 , C07C323/63 , C07C323/22 , C07C233/11 , C07C69/618 , C07C63/66 , C07C57/42
CPC classification number: C07C323/56 , C07C59/68 , C07C65/36 , C07C65/38 , C07C229/60 , C07C233/05 , C07C251/24 , C07C251/86 , C07C255/41 , C07C271/22 , C07C275/24 , C07C275/42 , C07C317/44 , C07C323/22 , C07C323/60 , C07C323/62 , C07C2603/18 , C07D207/333 , C07D249/14 , C07D277/20 , C07D303/38 , C07D333/70 , C07D409/14 , C07K5/06026 , C07K5/0806
Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Abstract translation: 本发明提供能够结合Fc受体并调节Fc受体活性的化合物，其包含被富含p电子的基团取代的芳基形式的核心亲油基团。 本发明还提供了使用这些化合物治疗涉及Fc受体活性的自身免疫性疾病的方法。 还提供了一种获得调节Fc受体活性的化合物的方法，该方法包括：（a）提供或设计具有结构特征的化合物，以配合FcγRIIa结构的凹槽; 和（b）筛选化合物以调节对Fc受体的活性。
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6.发明申请CANCER VACCINE COMPRISING A MUCIN 1 (MUC1) T CELL EPITOPE-DERIVED PEPTIDE 审中-公开包含MUCIN 1（MUC1）T细胞EPITOPE衍生肽的癌症疫苗公开(公告)号：US20090317414A1
公开(公告)日：2009-12-24
申请号：US12374591
申请日：2007-07-25
CPC classification number: C07K14/4727 , A61K39/0011 , A61K2039/6081
Abstract: A cancer vaccine, and a composition for the ex vivo priming of dendritic cells, is disclosed which comprises a MUC1 T cell epitope-derived peptide or peptide analogue capable of provoking a cytotoxic T cell immune response. Particular MUC1 T cell epitope-derived peptides disclosed include TTAPPVHGL, STAPPVHGL, STAPPAHGL, TTAPPAHGV and SAPDTYPAL.
Abstract translation: 公开了一种癌症疫苗和用于树突状细胞的离体引发的组合物，其包含能够引发细胞毒性T细胞免疫应答的MUC1T细胞表位衍生肽或肽类似物。 公开的特异性MUC1T细胞表位衍生的肽包括TTAPPVHGL，STAPPVHGL，STAPPAHGL，TTAPPAHGV和SAPDTYPAL。
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公开(公告)号：US07332631B2
公开(公告)日：2008-02-19
申请号：US10541045
申请日：2003-12-24
Applicant: Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
Inventor： Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
IPC: C07C321/28
CPC classification number: C07C323/56 , C07C59/68 , C07C65/36 , C07C65/38 , C07C229/60 , C07C233/05 , C07C251/24 , C07C251/86 , C07C255/41 , C07C271/22 , C07C275/24 , C07C275/42 , C07C317/44 , C07C323/22 , C07C323/60 , C07C323/62 , C07C2603/18 , C07D207/333 , C07D249/14 , C07D277/20 , C07D303/38 , C07D333/70 , C07D409/14 , C07K5/06026 , C07K5/0806
Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Abstract translation: 本发明提供能够结合Fc受体并调节Fc受体活性的化合物，其包含被富含p电子的基团取代的芳基形式的核心亲油基团。 本发明还提供了使用这些化合物治疗涉及Fc受体活性的自身免疫性疾病的方法。 还提供了一种获得调节Fc受体活性的化合物的方法，所述方法包括：（a）提供或设计具有结构特征的化合物，以配合FcγRIIa结构的凹槽; 和（b）筛选化合物以调节对Fc受体的活性。
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公开(公告)号：US20110144170A1
公开(公告)日：2011-06-16
申请号：US13031136
申请日：2011-02-18
Applicant: Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
Inventor： Mark Phillip Hogarth , Geoffrey Allan Pietersz , Gerard Peter Moloney
IPC: A61K31/41 , C07C63/49 , A61K31/194 , C07D333/70 , A61K31/381 , C07D403/12 , C07C63/313 , C07D207/34 , A61K31/40 , C07C255/41 , A61K31/277 , C07D303/48 , A61K31/336 , C07D249/14 , A61K31/4196 , C07C271/22 , A61K31/27 , A61P19/02 , A61P1/00 , G01N33/53
CPC classification number: C07C323/56 , C07C59/68 , C07C65/36 , C07C65/38 , C07C229/60 , C07C233/05 , C07C251/24 , C07C251/86 , C07C255/41 , C07C271/22 , C07C275/24 , C07C275/42 , C07C317/44 , C07C323/22 , C07C323/60 , C07C323/62 , C07C2603/18 , C07D207/333 , C07D249/14 , C07D277/20 , C07D303/38 , C07D333/70 , C07D409/14 , C07K5/06026 , C07K5/0806
Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Abstract translation: 本发明提供能够结合Fc受体并调节Fc受体活性的化合物，其包含被富含p电子的基团取代的芳基形式的核心亲油基团。 本发明还提供了使用这些化合物治疗涉及Fc受体活性的自身免疫性疾病的方法。 还提供了一种获得调节Fc受体活性的化合物的方法，该方法包括：（a）提供或设计具有结构特征的化合物，以配合FcγRIIa结构的沟槽; 和（b）筛选化合物以调节对Fc受体的活性。
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公开(公告)号：US20110033493A1
公开(公告)日：2011-02-10
申请号：US12813982
申请日：2010-06-11
Applicant: Ian Farquhar Campbell McKenzie , Geoffrey Allan Pietersz , Christina Cheers , John Stambas
Inventor： Ian Farquhar Campbell McKenzie , Geoffrey Allan Pietersz , Christina Cheers , John Stambas
IPC: A61K39/385
CPC classification number: A61K31/715 , A61K39/0208 , A61K39/04 , A61K39/12 , A61K39/15 , A61K39/385 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/55583 , A61K2039/57 , A61K2039/6087 , C12N2710/20034 , C12N2720/12334 , Y02A50/412
Abstract: The present invention provides a method of immunising a subject comprising the step of administering a composition comprising an antigen and a carbohydrate polymer comprising mannose to a mucosal site of the subject, methods of use of the composition for vaccination and sterilization and use of the composition in manufacturing a medicament.
Abstract translation: 本发明提供免疫受试者的方法，包括以下步骤：将包含抗原和包含甘露糖的碳水化合物聚合物的组合物施用于受试者的粘膜部位，使用该组合物进行疫苗接种和灭菌的方法以及使用该组合物 制造药物。
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