Robotic autosampler for automated electrospray from a microfluidic chip
    1.
    发明申请
    Robotic autosampler for automated electrospray from a microfluidic chip 审中-公开
    用于微流控芯片自动电喷雾的机器人自动进样器

    公开(公告)号:US20050145787A1

    公开(公告)日:2005-07-07

    申请号:US11054165

    申请日:2005-02-09

    摘要: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays in communication with a detector, includes: providing a robot autosampler having an electrospray chip; electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    摘要翻译: 机器人自动进样器提供具有多个电喷雾装置和/或用于与质谱仪或其他检测装置接口的样品入口的微流体芯片的自动操作。 自动进样器还提供了将控制电压连接到电喷雾装置,以便于带电液滴和离子的启用,控制和转向。 自动进样器还提供可以是一次性的或可重复使用的流体输送方法。 输送装置可以含有用于组分分离或样品纯化的材料。 输送装置可以包含预加载的样品,或者样品可以由自动进样器装载。 一种用于自动操作与检测器通信的多个电喷雾的方法,包括:提供具有电喷雾芯片的机器人自动进样器; 从电喷雾芯片上的至少一个电喷雾装置电喷雾至少一种分析物; 以及以检测来自电喷雾的分析物的方式操纵与检测器通信的电喷雾芯片。