Mif adsorbant
    2.
    发明申请
    Mif adsorbant 审中-公开
    Mif吸附剂

    公开(公告)号:US20090163599A1

    公开(公告)日:2009-06-25

    申请号:US11596534

    申请日:2005-06-03

    IPC分类号: A61K31/137 A61P29/00

    摘要: The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.

    摘要翻译: 本发明涉及一种分离物质或吸附剂以及从血液,血浆,血清或其他体液中去除,消耗或失活MIF(巨噬细胞迁移抑制因子)的方法。 本发明还涉及使用所述单采血浆物质或吸附剂。 为了制备一种新颖的方法和新颖的方法,其可以以比现有技术手段更令人愉快和可耐受的方式,减少患者体液中败血症和败血症休克的介体的活性或量 和方法,本发明提出,单采血浆材料或吸附剂在其表面上包含固定有MIF结合分子或官能团的固体载体材料。 该方法提出将血浆,血浆,血清或其他体液与体外血浆物质或吸附剂接触体外。