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    Mif adsorbant
    1.
    发明申请
    Mif adsorbant 审中-公开
    Mif吸附剂

    公开(公告)号：US20090163599A1

    公开(公告)日：2009-06-25

    申请号：US11596534

    申请日：2005-06-03

    申请人： Markus Storr ,  Reinhold Deppisch ,  Werner Beck ,  Jürgen Bernhagen ,  Ina Merz ,  Georg Geiger

    发明人： Markus Storr ,  Reinhold Deppisch ,  Werner Beck ,  Jürgen Bernhagen ,  Ina Merz ,  Georg Geiger

    IPC分类号： A61K31/137 ,  A61P29/00

    CPC分类号： B01J20/328 ,  A61M1/3679 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3255 ,  B01J20/3274 ,  B01J20/3278

    摘要： The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.

    摘要翻译： 本发明涉及一种分离物质或吸附剂以及从血液，血浆，血清或其他体液中去除，消耗或失活MIF（巨噬细胞迁移抑制因子）的方法。 本发明还涉及使用所述单采血浆物质或吸附剂。 为了制备一种新颖的方法和新颖的方法，其可以以比现有技术手段更令人愉快和可耐受的方式，减少患者体液中败血症和败血症休克的介体的活性或量 和方法，本发明提出，单采血浆材料或吸附剂在其表面上包含固定有MIF结合分子或官能团的固体载体材料。 该方法提出将血浆，血浆，血清或其他体液与体外血浆物质或吸附剂接触体外。

    Extracorporeal endotoxin removal method
    4.
    发明授权
    Extracorporeal endotoxin removal method 有权
    体外内毒素去除法

    公开(公告)号：US06774102B1

    公开(公告)日：2004-08-10

    申请号：US09677375

    申请日：2000-09-15

    申请人： Carl-Martin Bell ,  Markus Storr ,  Werner Beck

    发明人： Carl-Martin Bell ,  Markus Storr ,  Werner Beck

    IPC分类号： A61K3802

    CPC分类号： B01D67/0093 ,  A61L2/0017 ,  A61L2/0082 ,  A61M1/3679 ,  B01D61/00 ,  B01D69/141 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3274 ,  C07K1/22 ,  C07K1/34 ,  C08G69/10

    摘要： This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the invention are oligopeptides synthesized from amino acids having a pk>7.2 such as arginine, lysine or histidine, using a polycondensation step such that the resultant oligopeptides exhibit a high degree of polydispersity. Also provided are methods and devices using an adsorbent having a polydisperse oligopeptide of the invention immobilized on a solid state support medium for removing endotoxin from the blood of human or animal subject.

    摘要翻译： 本发明描述了具有通过用于治疗性脓毒性休克治疗的体外吸附从血液或血浆中选择性地除去内毒素和细胞因子诱导物质的能力的血液处理材料。 本发明的内毒素吸附配体是使用pk> 7.2的氨基酸合成的寡肽，例如精氨酸，赖氨酸或组氨酸，使用缩聚步骤，使得所得的寡肽表现出高度的多分散性。 还提供了使用固定在固态支持介质上的具有本发明的多分散寡肽的吸附剂的方法和装置，用于从人或动物受试者的血液中除去内毒素。

    ENZYME-FUNCTIONALIZED SUPPORTS
    6.
    发明申请
    ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
    酶功能化支持

    公开(公告)号：US20120208256A1

    公开(公告)日：2012-08-16

    申请号：US13503204

    申请日：2010-10-20

    申请人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    发明人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    IPC分类号： C12N11/06 ,  C12N11/02

    CPC分类号： C12N9/18 ,  C09D133/14 ,  C12N9/80 ,  C12N11/06 ,  C12N11/08

    摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.

    摘要翻译： 固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。 制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。 可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。 如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。 该方法还包括将酶偶联到聚合物链的氨基官能团。

    Separating material
    7.
    发明授权
    Separating material 有权
    分离材料

    公开(公告)号：US08142844B2

    公开(公告)日：2012-03-27

    申请号：US10572703

    申请日：2004-08-30

    申请人： Markus Storr ,  Egbert Müller ,  Wolfgang Freudemann

    发明人： Markus Storr ,  Egbert Müller ,  Wolfgang Freudemann

    IPC分类号： B05D3/12 ,  B01D39/14

    CPC分类号： A61L2/0017 ,  B01D63/02 ,  B01D63/026 ,  B01D67/0006 ,  B01D67/0018 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/125 ,  B01D71/40 ,  B01D71/78 ,  B01D2313/44 ,  B01D2323/38 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/3278 ,  B01J2220/62 ,  C08F257/02 ,  C08F265/04 ,  C08F265/10 ,  C08F267/10 ,  C08F271/00 ,  C08F271/02 ,  C08F285/00 ,  C08F289/00 ,  C08F291/00

    摘要： The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.

    摘要翻译： 本发明提供一种分离材料，其可通过以下步骤提供：a）提供具有与基底表面偶联的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c）使基材表面 在可发生单体的热引发的接枝共聚的条件下，使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法，该方法是：a）提供具有偶联到基底表面的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c） 在单体发生热引发的接枝共聚的条件下，在基材表面上形成相邻的官能聚合物链的结构的条件下，可聚合单体的溶液的底物表面。

    Separating material
    8.
    发明申请
    Separating material 有权
    分离材料

    公开(公告)号：US20060264355A1

    公开(公告)日：2006-11-23

    申请号：US10572703

    申请日：2004-08-30

    申请人： Markus Storr ,  Egbert Muller ,  Wolfgang Freudemann

    发明人： Markus Storr ,  Egbert Muller ,  Wolfgang Freudemann

    IPC分类号： A61K38/00 ,  A61M37/00

    CPC分类号： A61L2/0017 ,  B01D63/02 ,  B01D63/026 ,  B01D67/0006 ,  B01D67/0018 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/125 ,  B01D71/40 ,  B01D71/78 ,  B01D2313/44 ,  B01D2323/38 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/3278 ,  B01J2220/62 ,  C08F257/02 ,  C08F265/04 ,  C08F265/10 ,  C08F267/10 ,  C08F271/00 ,  C08F271/02 ,  C08F285/00 ,  C08F289/00 ,  C08F291/00

    摘要： The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.

    摘要翻译： 本发明提供一种分离材料，其可通过以下步骤提供：a）提供具有与基底表面偶联的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c）使基材表面 在可发生单体的热引发的接枝共聚的条件下，使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法，该方法是：a）提供具有偶联到基底表面的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c） 在单体发生热引发的接枝共聚的条件下，在基材表面上形成相邻的官能聚合物链的结构的条件下，可聚合单体的溶液的底物表面。